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Title: |
US7375404:
Fabrication and integration of polymeric bioMEMS
[ Derwent Title ]

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Country: |
US United States of America

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Inventor: |
Park, Jung Jin; Beltsville, MD, United States of America
Ghodssi, Reza; Rockville, MD, United States of America
Rubloff, Gary W.; Clarksville, MD, United States of America
Kastantin, Mark Joseph; Goleta, CA, United States of America
Li, Sheng; Greenbelt, MD, United States of America
Wu, Li-Qun; N. Potomac, MD, United States of America
Yi, Hyunmin; Beltsville, MD, United States of America
Valentine, Theresa Michelle; Potomac, MD, United States of America

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Assignee: |
University of Maryland Biotechnology Institute, Baltimore, MD, United States of America
University of Maryland, College Park, College Park, MD, United States of America
other patents from UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE (731396) (approx. 38)
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Published / Filed: |
2008-05-20
/ 2004-12-03

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Application Number: |
US2004000003005

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IPC Code: |
Advanced:
B01L 3/00;
B81B 7/00;
B81C 3/00;
H01L 27/14;
H01L 29/86;
Core:
H01L 29/66;
more...

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ECLA Code: |
B01L3/00C6M; B81B7/00P8; B81C3/00D; L01L200/00A8M; L01L200/00M; L01L300/00C2; L01L300/00D4E; L01L300/00G2; L01L300/00G4C; L01L300/00G12; L81B201/05Z; L81D1/00;

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U.S. Class: |
257/414;
257/040;

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Field of Search: |
257/414,415,40

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Government Interest: |
GOVERNMENT LICENSING CLAUSE
The U.S. Government has a paid-up license in this invention and the right in limited circumstances to require the patent owner to license others on reasonable terms as provided for by the terms of Grant No. DMR 4-32291 awarded by the National Science Foundation.

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Priority Number: |
| 2004-12-03 |
US2004000003005 |
| 2003-12-05 |
US2003000527394P |
| 2004-06-09 |
US2004000578207P |

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Abstract: |
A micro-electro-mechanical system (MEMS) device is provided, along with means for its fabrication and operation for microfluidic and/or biomicrofluidic applications. The MEMS device includes a substrate, optional electrodes on the substrate, a patterned structure on the substrate, the patterned structure having a fluidic microchannel aligned with one or more of the optional electrodes, an encapsulation membrane covering the microchannel, and an optional reactive layer deposited over the electrode in the microchannel. MEMS devices of preferred embodiments permit a leak-tight seal to be formed around the microchannel and fluidic interconnects established for robust operation of fluidics-based processes. MEMS devices of other preferred embodiments permit reversible attachment and separation of the encapsulation membrane relative to the patterned structure.

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Attorney, Agent or Firm: |
Edell, Shapiro & Finnan, LLC ;
Auerbach, Jeffrey I. ;
Cohan, June E. ;

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Primary / Asst. Examiners: |
Nguyen, Tuan H.;

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INPADOC Legal Status: |
None
Family Legal Status Report

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Parent Case: |
RELATED APPLICATIONS
This application claims the benefit of priority of U.S. provisional application Ser. No. 60/527,394 filed in the U.S. Patent & Trademark Office on Dec. 5, 2003 entitled “Fabrication and Integration of Polymeric BioMEMS,” the complete disclosure of which is incorporated herein by reference.
This application also claims the benefit of priority of U.S. provisional application Ser. No. 60/578,207 filed in the U.S. Patent & Trademark Office on Jun. 9, 2004 entitled “Micro-Knife-Edge Technique for Sealing of Microfluidic Systems,” the complete disclosure of which is incorporated herein by reference.

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Family: |
Show 2 known family members

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First Claim:
Show all 40 claims |
1. A micro-electro-mechanical system (MEMS) device, comprising: a substrate; a patterned structure on the substrate, the patterned structure having a microchannel; and an encapsulation layer covering the microchannel, the encapsulation layer being reversibly attachable and separable with respect to the patterned structure; wherein: the patterned structure comprises an epoxy; and the encapsulation layer comprises polydimethylsiloxane.

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Background / Summary: |
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Drawing Descriptions: |
Show drawing descriptions

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Description: |
Show description

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Foreign References: |

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Other References: |
Sun et al., Tyronsinase-Containing Chitosan Gels: A Combined Catalysts and Sorbent for Selective Phenol Removal. Biotechnology and Bioengineering, vol. 51, pp. 79-86, (1996).
Tatsumi, K. et al., Removal of Phenols from Wastewater by an Enzyme and Chitosan, Advances in Chitin Sciences, vol. 2, pp. 864-869 (1997).
Muzzarelli, et al.,TYrosinase-Mediated Quinone Tanning of Chitinous Materials, Carbohydrate Polymers, vol. 24, pp. 295-300 (1994).
Wada et al., “Removal of Phenols and Aromatic Amines from Wastewater by a Combination . . . a Coagulent,” Biotechnology and Bioengineering, vol. 45, pp. 304-309 (1995).
Payne et al., “Tyrosinase Reaction/Chitosan Adsorption for Selectively Removing Phenols from Aqueous Mixtures,” Biotechnology & Bioengineering, 40, No. 9 (1992).
Seong, et al., “Fabrication of Microchambers Defined by Photopolymerized Hydrogels and Weirs . . . ,” Analytical Chemistry, vol. 74, No. 14, pp. 3372-3377 (2002).
Gao, et al., “Lateral Patterning of CDTe Nanocrystal Films by the Electric Field Directed Layer-by-Layer Assembly Method,” Langmuir, vol. 18, pp. 4098-4102 (2002).
Chen et al., “pH-Sensitive Thin Hydrogel Microfabricated by Photolithography,” Langmuir, vol. 14, pp. 6610-6612 (1998).
Beebe, et al., “Functional Hydrogel Structures for Autonomous Flow Control Inside Microfluidic Channels,” Nature, vol. 404, pp. 588-590 (2000).
Sirkar et al., “Amperometric Biosensors Based on Oxidoreductases Immobilized in Photopolymerized . . . ,” Analytic Chemistry, vol. 70, No. 14, pp. 2888-2984 (1998).
Li-Qun Wu, et al., “Chitosan-Mediated and Spatially Selective Electrodeposition of Nanoscale Particles,” Langmuir, vol. 21, No. 8, pp. 3641-3646 (2005).
Li-Qun Wu, et al., “Spatially Selective Deposition of a Reactive Polysaccharide Chitosan Layer onto a Patterned Template,” Langmuir, vol. 19, No. 3, pp. 519-524 (2003).
Li-Qun Wu, et al., “Voltage-Dependent Assembly of the Polysaccharide Chitosan onto an Electrode Surface,” Langmuir, vol. 18, No. 22, pp. 8620-8625 (2002).
Tianhong Chen, et al., “Enzymatic Methods for in Situ Cell Entrapment and Cell Release,” Biomacromolecules, vol. 4, No. 6, pp. 1558-1563 (2003).
Mark J. Kkastantin, et al., “Integrated Fabrication of Polymeric Devices for Biological Applications,” Invited Paper, Journal of Sensors and Materials, pp. 1-18 (Sep. 2003).
Tianhong Chen, et al., “Nature-Inspired Creation of Protein Polysaccharide Conjugate and Its Subsequent . . . Patterned Surface,” Langmuir, vol. 19, No. 22, pp. 9382-9386 (2003).
Rohan Fernandes, et al., “Electrochemical Induced Deposition of a Polysaccharide Hydrogel onto a Patterned Surface,” Langmuir vol. 19, No. 10, pp. 4058-4062 (2003).
Hyunmin, Yi, et al., “A Robust Technique for Assembly of Nucleic Acid Hybridization . . . Chitosan,” Analytical Chemistry, vol. 76, No. 2, pp. 365-372 (Jan. 15, 2004).
Rohan Fernandes, et al., “Thermo-Biolithography: A Technique for Patterning Nucleic Acids and Proteins,” Langmuir, vol. 20, No. 3, pp. 906-913 (2004).
Li-Qun Wu, et al., “Spatially Selective Asembly of a Reactive Polysaccharide Layer onto Patterned Surfaces,” Power Point Presentation of Nov. 8, 2002 (22 slides).
Takenaka, et al., “Sol-gel Preparation of a Single Layer, 0.75 Micron Thick Lead Zirconate Titanate Films . . . ,” Applied Physics Letters, vol. 79, No. 21, pp. 3485-3487 (2001).
O'Connor, et al., “Immobilization of Neural Cells in Three-Dimensional Matricesfor Biosensor Applications,” Biosensors & Bioelectrics, vol. 14, pp. 871-881 (2000).
Zhitomirsky, et al., “Cathodic Electrodeposition of Polymer Films and Organoceramic Films,” Material Science and Engineering, vol. B78, pp. 125-130 (2000).
Chen, et al., “Self-Assembly of Monolayers of Cadmium Selenide Nanocrystals with Dual Color Emission,” Langmuir, vol. 15, pp. 6845-6850 (1999).
Clark, “Engineering the Microfabrication of Layer-by-Layer Thin Films,” Advanced Materials (1998).
Gray, et al., “Interlocking Mechanical and Fluidic Interconnections for Microfluidic Circuit Boards”, Sensors and Actuators a-Physical, vol. 112, No. 1, pp. 18-24, 2004.
Li, et al., “Fabrication of Micronozzles Using Low-temperature Wafer-level Bonding with SU-8”,Journal of Micromechanics and Microengineering,vol. 13, No. 5, pp. 732-738, 2003.
Duffy, et al., “Rapid Prototyping of Microfluidic Systems in Poly (dimethylsiloxane).” Analytical Chemistry, vol. 70, No. 23, pp. 4974-4984, 1998.
Harrison, et al., “Capillary Electrophoresis and Sample Injection Systems Intergrated on a Planar Glass Chip”, Analytical Chemistry, vol. 64, No. 17, pp. 1926-1932, 1996.
Liang, et al., “Microfabrication of a Planar Absorbance and Fluorescence Cell for Integrated Capillary Electrophoresis Devices”, Analytical Chemistry, vol. 68, pp. 1040-1046,1996.
Voldman, et al., “An Integrated Liquid Mixer/Valve”, Journal of Microelectromechanical Systems, vol. 9, No. 3, pp. 295-302, 2001.
Glasgow, et al., “Handling Individual Mammalian Embryos Using Microfluidics”, IEEE Transactions on Biomedical Engineering, vol. 48, No. 5, pp. 570-577, 2001.
Fujii, et al., “PDMS-based Microfluidic Device for Biomedical Applications”, Microelectronic Engineering, vol. 61-62, pp. 907-914, 2002.
Yamaguchi, et al., “Rapid Fabrication of Electrochemical Enzyme Sensor Chip Using Polydimethylsiloxane Microfluidic Channel”, Analytica Chemica Acta,vol. 468, pp. 143-152, 2002.
Kim, et al., “A New Monolithic Microbiosensor for Whole Blood Analysis”, Sensors and Actuators, vol. A 95, pp. 108-113, 2002.
Trumbull, et al., “Integrating Microfabricated Fluidic Systems and NMR Spectroscopy”, IEEEE Transactions on Biomedical Engineering, vol. 47, No. 1, pp. 3-7, 2000.
Krishnan, et al., “Microfabricated Reaction and Separation Systems”, Curr. Opinion Biotech, vol. 12, pp. 92-98, 2001.
Hatch, et al., “A Ferrofluidic Magnetic Micropump”, Journal of Microelectromechanical Systems, vol. 10, No. 2, pp. 215-221, 2001.
Xia, et al., “Soft Lithography”, Angew. Chem. Int. Ed. vol. 37, pp. 550-575, 1998.
Boer, et al., “Micromachining of Buried Micro Channels in Silicon”, Journal of Microelectromechanical Systems, vol. 9, No. 1, pp. 94-103, 2000.
Kovacs, et al., “Bulk Micromachining of Silicon”, Proceedings of IEEE, vol. 86, No. 8, pp. 1536-1551, 1998.
Bustillo, et al., “Surface Micromachining for Microelectromechanical Systems”, vol. Proceedings of IEEE, vol. 86, No. 8, pp. 1552-1574, 1998.
Lin, et al., “A Fast Prototyping Process for Fabrication of Microfluidic Systems on Soda-lime Glass”,Journal of Micromechanics and Microengineering, vol. 11, pp. 726-732, 2001.
Morgan, et al., “Compensated Aspect Ratio Dependent Etching (CARDE) Using Gray-scale Technology”, Microelectronic Engineering, vol. 77, pp. 85-94, 2005.
Waits, et al., “Investigatino of Gray-scale Technology for Large Area 3D Silicon MEMS Structures”, Journal of Micromechanics and Microengineering, vol. 13, pp. 170-177, 2003.
Beebe, et al., “Physics and Application of Microfluidics in Biology”, Annual Review of Biomedical Engineering, vol. 4, pp. 261-286, 2002.
Jacobson, et al., “High-Speed Separations on a Microchip”, Anal. Chem., vol. 66, pp. 1114-1118, 1994.
Erickson, et al., “Integrated Microfluidic Devices”, Analytica Chimica Acta, Vo. 507, No. 1, pp. 11-26, 2004.
Han, et al., “An Approach to Multilayer Microfluidic Systems with Integrated Electrical, Optical, and Mechanical Functionality”, IEEE Sensors Journal,vol. 5,No. 1,pp. 82-89,2005.
Fujii, Teruo, “PDMS-based Microfluidic Devices for Biomedical Applications”, Microelectronic Engineering, 61-62, pp. 907-914, 2002.

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Continuity Data: |
| Application Number | Filed | Notes |
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US2004000003005 | 2004-12-03 | is a
related to the prior publication |
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US20050230767A1 issued 2005-10-20 Fabrication and integration of polymeric bioMEMS
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US2004000003005 | 2004-12-03 | is a
non-provisional of provisional |
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US2004000578207P
| 2004-06-09 |
|
|
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US2004000003005 | 2004-12-03 | is a
non-provisional of provisional |
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US2003000527394P
| 2003-12-05 |
|

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