SYNTHETIC HUMAN GROWTH-PROMOTING AND LACTOGENIC HORMONES AND METHOD OF PRODUCING SAME (US3853833)

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US3853833: SYNTHETIC HUMAN GROWTH-PROMOTING AND LACTOGENIC HORMONES AND METHOD OF PRODUCING SAME

US United States of America

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Li, Choh Hao; Berkeley, CA

Hormone Research Foundation, Berkeley, CA
other patents from HORMONE RESEARCH FOUNDATION (257415) (approx. 2)
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Published / Filed:

1974-12-10 / 1971-07-15

Application Number:

US1971000162946

Advanced: C07K 1/00; C07K 7/06;
IPC-7: C07C 103/52; C07G 7/00; C08H 1/00;

C07K7/06; C07K1/00B;

Current: 530/334; 930/120; 930/260;
Original: 260/112.5; 424/177;

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Priority Number:

US1971000162946

Synthetic human growth-promoting and lactogenic hormones, e.g., pituitary growth hormone (HGH) is produced by attaching phenylalanine, the COOH terminal amino acid of HGH, to a solid resin support, and then coupling stepwise to the supported acid the remaining amino acid residues of the hormone molecule, using the general technique of solid phase peptide synthesis with suitable protective and blocking groups, and deblocking and coupling agents. The resulting synthetic polypeptide chain of amino acid residues is liberated from the resin support and all protecting groups are removed. Then the synthetic hormone is oxidized under controlled conditions effective to form two disulfide bridges across the cysteine residues in the chain, thereby forming the two intra-molecular rings which are required to reproduce the correct conformation of the HGH molecule. The resulting synthetic hormone reacts immunologically with rabbit antiserum to HGH and possesses growth-promoting and lactogenic activity.

Attorney, Agent or Firm:

Pennie & Edmonds ;

Primary / Asst. Examiners:

Gotts, Lewis; Suyat, Reginald J.

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Related Applications:

Application Number	Filed	Patent	Pub. Date	Title
US1971000137811	1971-04-27


	Parent Case:			CROSS-REFERENCE TO RELATED APPLICATION This application is a continuation-in-part of a prior co-pending application Ser. No. 137,811, filed Apr. 27, 1971.
	Family:			Show 10 known family members
	First Claim: Show all 30 claims			I claim: 1. A method of producing synthetic human pituitary growth hormone which comprises: a. forming an unbridged polypeptide chain of amino acid residues in the sequence of natural human pituitary growth hormone; b. generating sulfhydryl groups on the cysteine residues in said polypeptide chain; c. oxidizing said sulfhydryl groups under conditions effective to form disulfide bridges between said cysteine residues, thereby forming two intra-molecular rings in the polypeptide chain.
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	Forward References:			Show 14 U.S. patent(s) that reference this one


	U.S. References:			Go to Result Set: All U.S. references \| Forward references (14) \| Backward references (0) \| Citation Link


	Foreign References:			None
	Other Abstract Info:			CHEMABS 078(05)030199Z
	Other References:			Li et al., J. Am. Chem. Soc., 92, 7608(1970). Bewley et al., Arch. Biochem. Biophys., 138, 338 (1970). Cited by 2 patents Li et al., Arch. Biochem. Biophys, 133, 70-73, 89-90 (1969). Bewley et al., Biochim. Biophys. Acta, 154, 420 (1968). Bewley et al., Arch. Biochem. Biophys., 144, 589 (1971). Catt et al., Science, 157, 321 (1967).
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