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 Title: |
US4321365:
Oligonucleotides useful as adaptors in DNA cloning, adapted DNA molecules, and methods of preparing adaptors and adapted molecules
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Wu, Ray J.; Ithaca, NY
Bahl, Chander P.; Concord, CA
Narang, Saran A.; Ottawa, Canada
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| Assignee: |
Research Corporation, New York, NY
other patents from RESEARCH CORPORATION (471740) (approx. 685)
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| Published / Filed: |
1982-03-23
/ 1977-10-19
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| Application Number: |
US1977000843422
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| IPC Code: |
Advanced:
C07H 21/00;
C12N 15/00;
IPC-7:
C07H 21/04;
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| ECLA Code: |
C07H21/00; C12N15/00;
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| U.S. Class: |
Current:
536/024.2;
435/091.41;
435/320.1;
536/025.1;
Original:
536/027;
536/028;
536/029;
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| Field of Search: |
536/026-29
435/317,172
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| Government Interest: |
The invention described herein was made in the course of work under a grant, GM-18887, from the Department of Health, Education and Welfare.
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| Priority Number: |
| 1977-10-19 |
US1977000843422 |
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| Abstract: |
Synthetic oligonucleotides have been designed and prepared which are useful in the molecular cloning of a variety of DNA molecules. By means of such oligonucleotides, genetic informational material, e.g., DNA, can be joined to a cloning vehicle and transferred into host cells by transformation. Additionally, a method for determining whether genetic informational material has been transferred into transformed host cells has been developed.
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| Attorney, Agent or Firm: |
Cooper, Dunham, Clark, Griffin & Moran ;
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| Primary / Asst. Examiners: |
Hazel, Blondel;
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| INPADOC Legal Status: |
Show legal status actions
Family Legal Status Report
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| Family: |
Show 2 known family members
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First Claim:
Show all 19 claims |
We claim:
1. An adaptor molecule useful for attaching DNA containing genetic information to a cloning vehicle consisting of DNA which comprises a double-stranded oligodeoxyribonucleotide having at one end thereof a protruding nucleotide sequence which is the recognition site for a restriction endonuclease.
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| Background / Summary: |
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| Drawing Descriptions: |
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| Description: |
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| Forward References: |
Show 42 U.S. patent(s) that reference this one
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| Foreign References: |
None
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| Other Abstract Info: |
CHEMABS 097(01)001590G
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| Other References: |
Marians et al., Nature, vol. 263, pp. 744-748 (1976).
(5 pages)
Cited by 14 patents
Heyneker et al., Nature, vol. 263, pp. 748-752 (1976).
(5 pages)
Cited by 10 patents
Scheller et al., Science, vol. 196, pp. 177-180 (1977).
Bahl et al., Gene 1, 81-92 (1976).
(12 pages)
Cited by 9 patents
Pribnow, Proc. Nat. Acad. Sci., vol. 72, pp. 784-788, 1975.
(5 pages)
Cited by 9 patents
Polisky et al., Proc. Nat. Acad. Sci., vol. 73, pp. 3900-3905 (1976).
(5 pages)
Cited by 26 patents
Itakura et al., Science, vol. 198, pp. 1056-1066 (1977).
(8 pages)
Cited by 180 patents
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