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 Title: |
US4356270:
Recombinant DNA cloning vehicle
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Itakura, Keiichi; Arcadia, CA
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| Assignee: |
Genentech, Inc., San Francisco, CA
other patents from GENENTECH, INC. (218000) (approx. 2,164)
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| Published / Filed: |
1982-10-26
/ 1979-11-05
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| Application Number: |
US1979000091334
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| IPC Code: |
Advanced:
C07H 21/00;
C12N 15/00;
IPC-7:
C12N 1/00;
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| ECLA Code: |
C07H21/00; C12N15/00; M07K319/71;
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| U.S. Class: |
Current:
435/320.1;
435/069.4;
435/069.8;
435/073;
930/010;
930/160;
930/240;
Original:
435/317;
435/172;
435/068;
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| Field of Search: |
435/172,317,68,70,71
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| Priority Number: |
| 1979-11-05 |
US1979000091334 |
| 1978-11-04 |
HU19780GE001050 |
| 1977-11-08 |
US1977000849691 |
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| Abstract: |
The Specification discloses: 1. Recombinant microbial cloning vehicles comprising heterologous DNA coding for the expression of mammalian hormone (e.g., somatostatin) and other polypeptides, including plasmids suited for the transformation of bacterial hosts. The latter incorporate a regulon homologous to the host in its untransformed state, in reading phase with the structural gene for the heterologous DNA; 2. Cloning vehicles coding for the microbial expression of a protein variously comprising (a) a polypeptide hapten and additional protein sufficient in size to confer immunogenicity on the product of expression, which may find use in raising antibodies to the hapten for assay use or in the manufacture of vaccines; and (b) a desired polypeptide product and additional protein from which the desired product may be cleaved; and 3. Methods of preparing synthetic structural genes coding for the expression of mammalian polypeptides in microbial cloning systems.
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| Attorney, Agent or Firm: |
Kiley, Thomas D. ;
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| Primary / Asst. Examiners: |
Tanenholtz, Alvin E.;
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| Maintenance Status: |
CC Certificate of Correction issued
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| INPADOC Legal Status: |
Show legal status actions
Family Legal Status Report
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| Foreign References: |
None
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| Other Abstract Info: |
CHEMABS 091(21)171576A
DERC82-97410E
DERABS C82-97410E
DERABS C86-068721
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| Other References: |
Rensberger, New York Times, Team at M.I.T. Constructs a Fully Functioning Gene, Aug. 29, 1976.
Technology Review, pp. 12+13, Dec. 1976.
Fiers et al., Nature, vol. 260, pp. 500-507, Apr. 8, 1976.
(8 pages)
Cited by 5 patents
Sanger et al., Nature, vol. 265, pp. 687-695, Feb. 24, 1977.
(9 pages)
Cited by 7 patents
Air et al., J. Mol. Biol. vol. 96, pp. 703-719, 1975.
Cited by 4 patents
Air et al., J. Mol. Biol., vol. 107, pp. 445-458, 1976.
(14 pages)
Cited by 4 patents
Koester, Hoppe-Seyler's Z. Physiol. Chem., 356, 1585, pp. 203-220 (1975).
Ullrich et al., Science, vol. 196, pp. 1313-1319, Jun. 17, 1977.
Highuchi et al., Proc. Natl. Acad. Sci. USA, vol. 73, pp. 3146-3150, Sep. 1976.
Rabbitts, Nature, vol. 260, pp. 221-225, Mar. 1976.
(5 pages)
Cited by 16 patents
Polisky et al., Proc. Natl. Acad. Sci. USA, vol. 73, pp. 3900-3904, Nov. 1976.
(5 pages)
Cited by 26 patents
Marians et al., Nature, vol. 263, pp. 744-748, Oct. 28, 1976.
(5 pages)
Cited by 14 patents
Backman et al., Proc. Natl. Acad. Sci., vol. 73, pp. 4174-4178, Nov. 1976.
(5 pages)
Cited by 24 patents
Struhl et al., Proc. Natl. Acad. Sci., vol. 73, pp. 1471-1475, May 1976.
(5 pages)
Cited by 11 patents
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