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 Title: |
US4366246:
Method for microbial polypeptide expression
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Riggs, Arthur D.; La Verne, CA
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| Assignee: |
Genentech, Inc., So. San Francisco, CA
other patents from GENENTECH, INC. (218000) (approx. 2,164)
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| Published / Filed: |
1982-12-28
/ 1979-11-05
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| Application Number: |
US1979000090980
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| IPC Code: |
Advanced:
C07K 14/62;
C07K 14/655;
C12N 15/62;
IPC-7:
C12N 1/00;
C12N 15/00;
C12P 21/00;
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| ECLA Code: |
C07K14/62; C07K14/655; C12N15/62; M07K319/61; M07K319/75; M07K319/00;
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| U.S. Class: |
Current:
435/069.8;
930/160;
930/240;
Original:
435/068;
435/172;
435/317;
536/027;
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| Field of Search: |
435/172,68,317
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| Priority Number: |
| 1979-11-05 |
US1979000090980 |
| 1977-11-08 |
US1977000849591 |
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| Abstract: |
The Specification discloses: 1. Recombinant microbial cloning vehicles comprising heterologous DNA coding for the expression of mammalian hormone (e.g., somatostatin) and other polypeptides, including plasmids suited for the transformation of bacterial hosts. The latter incorporate a regulon homologous to the host in its untransformed state, in reading phase with the structural gene for the heterologous DNA; 2. Cloning vehicles coding for the microbial expression of a protein variously comprising (a) a polypeptide hapten and additional protein sufficient in size to confer immunogenicity on the product of expression, which may find use in raising antibodies to the hapten for assay use or in the manufacture of vaccines; and (b) a desired polypeptide product and additional protein from which the desired product may be cleaved; and 3. Methods of preparing synthetic structural genes coding for the expression of mammalian polypeptides in microbial cloning systems.
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| Attorney, Agent or Firm: |
Kiley, Thomas D. ;
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| Primary / Asst. Examiners: |
Tanenholtz, Alvin E.;
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| Maintenance Status: |
CC Certificate of Correction issued
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| INPADOC Legal Status: |
Show legal status actions
Family Legal Status Report
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| Foreign References: |
None
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| Other Abstract Info: |
CHEMABS 091(11)087206X
CAN098(15)120637H
CHEMABS 098(15)120637H
DERC83-07104K
DERABS C79-35257B
DERABS C83-07104K
DERABS C84-029658
DERABS C84-056011
DERABS C86-035095
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| Other References: |
Itakura et al., Science, vol. 198, pp. 1056-1063, Dec. 9, 1977.
(8 pages)
Cited by 180 patents
O'Farrell et al., J. Bacteriology, vol. 134, pp. 645-654 (May 1978).
(10 pages)
Cited by 19 patents
Casadaban, J. Mol. Biol., vol. 104, pp. 541, 557 (1976).
(15 pages)
Cited by 9 patents
Polisky et al., Proc. Natl. Acad. Sci., vol. 73, No. 14, pp. 3900-3904 (Nov. 1976).
(5 pages)
Cited by 26 patents
Higuchi et al., Proc. Natl. Acad. Sci., vol. 73, No. 9, pp. 3146-3150 (Sep. 1976).
(5 pages)
Cited by 32 patents
Ullrich et al., Science, vol. 196, pp. 1313-1319 (Jun. 17, 1977).
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