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 Title: |
US5422093:
Photochemotherapeutic method using 5-aminolevulinic acid and precursors thereof
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Kennedy, James C.; Kingston, Canada
Pottier, Roy H.; Kingston, Canada
Reid, Robert L.; Kingston, Canada
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| Assignee: |
Queen's University, Kington, Canada
other patents from QUEEN'S UNIVERSITY (461060) (approx. 19)
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| Published / Filed: |
1995-06-06
/ 1993-06-28
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| Application Number: |
US1993000082113
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| IPC Code: |
Advanced:
A61K 31/195;
A61K 31/555;
A61K 41/00;
IPC-7:
A61K 49/00;
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| ECLA Code: |
A61K31/195; A61K31/555; A61K41/00W; A61K41/00W4;
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| U.S. Class: |
Current:
424/009.61;
514/410;
514/561;
514/814;
514/843;
514/899;
540/145;
562/567;
Original:
424/009.61;
514/410;
514/561;
514/814;
514/843;
514/899;
540/145;
562/567;
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| Field of Search: |
514/561,410,814,843,899
540/145
562/567
424/7.1
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| Priority Number: |
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| Abstract: |
A method of detecting and treating malignant and non-malignant tissue abnormalities and lesions of the skin; conjunctiva; respiratory, digestive and vaginal mucosa; endometrium and urothelium; and for ablating the endometrial tissue and treating body fluids, including blood containing suspended abnormal cells, and for treating cancers of the nervous system in which 5-aminolevulinic acid or precursor thereof is administered to the patient in an amount sufficient to induce synthesis fluorescence and/or photosensitizing concentrations of a protoporphyrin IX in the abnormal cells, followed by exposure of the abnormal cells to light of photoactivating wavelengths.
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| Attorney, Agent or Firm: |
Hicks, Richard J. ;
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| Primary / Asst. Examiners: |
Hollinden, Gary E.;
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| Maintenance Status: |
CC Certificate of Correction issued
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| INPADOC Legal Status: |
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Family Legal Status Report
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| Parent Case: |
CROSS REFERENCE TO RELATED APPLICATIONS
This application is a continuation-in-part of U.S. application Ser. No. 07/865,151 filed Apr. 8, 1992, now U.S. Pat. No. 5,234,940 which is a continuation-in-part of U.S. application Ser. No. 07/783,750 filed Oct. 28, 1991, now U.S. Pat. No. 5,211,938 which is a continuation of U.S. application Ser. No. 07/386,414 filed Jul. 28, 1989 and now U.S. Pat. No. 5,079,262 issued Jan. 7, 1992.
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| Designated Country: |
AT BE CH DE DK ES FR GB IE IT LI SE BB BG BR CZ FI HU KP KR LK MG MN NZ OA PL RO RU SD SK UA
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| Family: |
Show 51 known family members
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First Claim:
Show all 21 claims |
We claim:
1. A method for treating or detecting in a patient rapidly growing cells that preferentially accumulate a photoactivatable porphyrin, comprising the steps of administering to said patient, or contacting said cells with, an effective amount of a precursor of protoporphyrin IX such that said cells accumulate therapeutic or detectable levels of said protoporphyrin IX, and thereafter exposing said cells to light capable of photoactivating said protoporphyrin IX.
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| Background / Summary: |
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| Drawing Descriptions: |
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| Description: |
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| Forward References: |
Show 46 U.S. patent(s) that reference this one
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