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 Title: |
US5589358:
Ileal bile acid transporter compositions and methods
[ Derwent Title ]
>> View Certificate of Correction for this publication
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| Country: |
US United States of America
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| Inventor: |
Dawson, Paul A.; Chapel Hill, NC 27514
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| Assignee: |
None
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| Published / Filed: |
1996-12-31
/ 1993-12-29
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| Application Number: |
US1993000176126
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| IPC Code: |
Advanced:
A61K 38/00;
A61K 39/395;
A61K 48/00;
A61P 1/04;
A61P 1/16;
A61P 3/06;
A61P 3/08;
A61P 9/00;
C07H 21/04;
C07K 7/08;
C07K 14/47;
C07K 14/705;
C07K 16/18;
C12N 15/09;
C12N 15/12;
C12P 21/02;
C12P 21/08;
C12Q 1/68;
G01N 33/577;
G01N 33/92;
C12R 1/91;
Core:
A61P 1/00;
A61P 3/00;
C07H 21/00;
C07K 7/00;
C07K 14/435;
more...
IPC-7:
C12N 15/12;
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| ECLA Code: |
C07K14/47; C07K14/705; C12Q1/68P; G01N33/92;
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| U.S. Class: |
Current:
435/069.1;
435/252.3;
435/320.1;
435/325;
435/348;
435/350;
435/352;
435/358;
435/364;
435/365;
435/367;
435/369;
530/846;
536/023.5;
536/024.3;
Original:
435/069.1;
435/172.3;
435/240.2;
435/252.3;
435/320.1;
536/023.5;
536/024.3;
530/846;
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| Field of Search: |
536/23.5,24.31,24.33,24.3
435/006,172.3,240.1,240.2,252.3,320.1,69.1
530/846
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| Government Interest: |
The government owns rights in the present invention pursuant to grant number DK08718 from the National Institutes of Health.
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| Priority Number: |
| 1993-12-29 |
US1993000176126 |
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| Abstract: |
Bile acids are absorbed from the small intestine by an passive and an active mechanism. The active mechanism involves a Na+ /bile acid cotransporter. A cDNA encoding the ileal bile acid cotransporter has been isolated and sequenced. The amino acid sequence of the cotransporter protein is also disclosed. The renal bile acid cotransporter is also shown to be identical to the ileal cotransporter. The cotransporter disclosed herein will have use in treatment of hypercholesterolemia, diabetes, heart disease and liver disease. In addition, methods of screening man made and naturally occurring substances for the discovery of new bile acid transport inhibitors and activators and methods of detecting mutations in human ileal/renal bile acid transporter genes are disclosed.
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| Attorney, Agent or Firm: |
Arnold, White & Durkee ;
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| Primary / Asst. Examiners: |
Walsh, Stephen G.; Spector, Lorraine
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| Maintenance Status: |
CC Certificate of Correction issued
View Certificate of Correction
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| INPADOC Legal Status: |
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Family Legal Status Report
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| Designated Country: |
AM AP BB BG BR BY CN CZ FI GE HU KE KG KP KR KZ LK LT LV MD MG MN AT BE CH DE DK ES FR GB GR IE IT LI LU MC
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| Family: |
Show 10 known family members
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First Claim:
Show all 22 claims |
What is claimed is:
1. An isolated DNA segment wherein said segment encodes a mammalian ileal/renal bile acid cotransporter having an amino acid sequence in accordance with seq id no:2 or seq id no:4.
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| Background / Summary: |
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| Drawing Descriptions: |
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| Description: |
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| Forward References: |
Show 6 U.S. patent(s) that reference this one
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| Foreign References: |
None
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| Other Abstract Info: |
CHEMABS 123(17)224430M
DERABS C1995-246189
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| Other References: |
Alves et al., "Bile Acid Transport into Hepatocyte Smooth Endoplasmic Reticulum Vesicles Is Mediated by Microsomal Epoxide Hydrolase, a Membrane Protein Exhibiting Two Distinct Topological Orientations," J. Biol. Chem., 268(27):20148-20155, 1993.
(8 pages)
Cited by 2 patents
[ISI abstract]
Barnard and Ghishan, "Taurocholate Transport by Human Ilean Brush Border Membrane Vesicles," Gastroenterology, 93:925-933, 1987.
(9 pages)
Cited by 2 patents
Barnes et al., "The Role of Tubular Reabsorption in the Renal Excretion of Bile Acids," Biochem. J., 166:65-73, 1977.
(9 pages)
Cited by 2 patents
Becker et al., "Characterisation of the ATP-dependent Taurocholate-carrier Protein (gp110) of the Hepatocyte Canalicular Membrane," Eur. J. Biochem., 214:539-548, 1993.
(10 pages)
Cited by 2 patents
[ISI abstract]
Boyer et al., "Phylogenic and Ontogenic Expression of Hepatocellular Bile Acid Transport," Proc. Natl. Acad. Sci. USA, 90:435-438, 1993.
(4 pages)
Cited by 2 patents
[ISI abstract]
Burckhardt et al., "Photoaffinity Labeling Studies of the Rat Renal Sodium/Bile Salt Cotransport System," Biochem. Biophys. Res. Commun., 143(3):1018-1023, 1987.
(6 pages)
Cited by 2 patents
Chandler et al., "Transepithelial Transport of Cholyltaurine by Caco-2 Cell Monolayers Is Sodium Dependent," Am. J. Physiol., 264(6):G1118-G1125, 1993.
(8 pages)
[ISI abstract]
Galeazzi and Javitt, "Bile Acid Excretion: the Alternate Pathway in the Hamster," J. Clin. Invest., 60:693-701, 1977.
(9 pages)
Cited by 2 patents
Hagenbuch et al., "Functional Expression Cloning and Characterization of the Hepatocyte Na+ /Bile Acid Cotransport System," Proc. Natl. Acad. Sci. USA, 88:10629-10633, 1991.
(5 pages)
Cited by 4 patents
[ISI abstract]
Hofmann et al., "Biological and Medical Aspects of Active Ileal Transport of Bile Acids," Annals of Medicine, 23:169-175, 191.
Kramer et al., "Liver-specific Drug Targeting by Coupling to Bile Acids," J. Biol. Chem., 267(26):18598-18604, 1992.
(7 pages)
Cited by 25 patents
[ISI abstract]
Kramer et al., "Characterization and Chemical Modification of the Na+ -dependent Bile-acid Transport System in Brush-border Membrane Vesicles from Rabbit Ileum," Biochim. Biophys. Acta, 1111:93-102, 1992.
(10 pages)
[ISI abstract]
Kramer et al., "Intestinal Bile Acid Absorption," J. Biol. Chem., 268(24):18035-18046, 1993.
(12 pages)
Cited by 22 patents
[ISI abstract]
Lack and Weiner, "In vitro Absorption of Bile Salts by Small Intestine of Rats and Guinea Pigs," Am. J. Physiol., 200(2):313-317, 1961.
Lack and Weiner, "Bile Salt Transport Systems," The Bile Acids, 2:33-54, 1973.
Lin et al., "Identification of Cytosolic and Microsomal Bile Acid-binding Proteins in Rat Ileal Enterocytes," J. Biol. Chem., 265(25):14986-14995, 1990.
(10 pages)
Cited by 2 patents
Lin et al., "Timed Photoaffinity Labeling and Characterization of Bile Acid Binding and Transport Proteins in Rat Ileum," Am. J. Physiol., 265 (Gastrointest. Liver Physiol. 28):G56-G62, 1993.
(7 pages)
Cited by 2 patents
[ISI abstract]
Mullins et al., "Characterization of the Ileal Na+ /Bile Sale Co-transporter in Brush Border Membrane Vesicles and Functional Expression in Xenopus laevis Oocytes," Biochem. J., 285:785-790, 1992.
(6 pages)
Cited by 2 patents
[ISI abstract]
Shneider et al., "Physiologic, Immunologic and Molecular Differences in Hepatic and Ileal Sodium-dependent Bile Acid Transport," Gastroenterology, 102(4) (Part 2):A888, 1992, abstract only.
Sippel et al., "The Rat Liver Ecto-ATPase Is Also a Canalicular Bile Acid Transport Protein," J. Biol. Chem., 268(3):2083-2091, 1993.
(9 pages)
Cited by 2 patents
[ISI abstract]
Von Dippe et al., "Na+ -dependent Bile Acid Transport by Hepatocytes is Mediated by a Protein Similar to Microsomal Epoxide Hydrolase," Am. J. Physiol., 264 (Gastrointest. Liver Physiol. 27):G528-G534, 1993.
(7 pages)
Cited by 2 patents
[ISI abstract]
Wilson et al., "Sodium-coupled Taurocholate Transport in the Proximal Convolution of the Rat Kidney in vivo and in vitro," J. Clin. Invest., 67:1141-1150, 1981.
Zimmerli et al., "Multispecificity of Na+ -dependent Taurocholate Uptake in Basolateral (Sinusoidal) Rat Liver Plasma Membrane Vesicles," J. Pharmacol. Exp. Ther., 250(1):301-308, 1989.
(8 pages)
Cited by 2 patents
Gong et al., "Effect of Antiserum to a 99 kDa Polypeptide on the Uptake of Taurocholic Acid by Rat Ileal Brush Border membrane Vesicles," Biochem. Biophys. Res. Commun., 179(1):204-209, 1991.
(6 pages)
Cited by 2 patents
[ISI abstract]
Sorscher et al., "Conjgated Bile Acid Uptake by Xenopus Laaevis Oocytes Induced by Microinjection with Ileal Poly A+ mRNA," Biochem. Biophys. Res. Commun., 186(3):1455-1462, 1992.
(8 pages)
Cited by 2 patents
[ISI abstract]
Wong et al., "Cloning and Characterization of the Ileal Bile Acid Transporter," AASLD Abstracts, 18(4):143A, Pt. 2, 1993.
(1 pages)
[ISI abstract]
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