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 Title: |
US5597559:
Ophthalmic formulation
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Olejnik, Orest; Trabuco Canyon, CA
Wendel, Fred W.; Asheboro, NC
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| Assignee: |
Ciba Geigy Corporation, Tarrytown, NY
other patents from CIBA-GEIGY CORPORATION (104245) (approx. 8,582)
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| Published / Filed: |
1997-01-28
/ 1994-10-26
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| Application Number: |
US1994000329808
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| IPC Code: |
Advanced:
A61K 9/00;
Core:
more...
IPC-7:
A61K 9/08;
A61K 31/765;
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| ECLA Code: |
A61K9/00M16;
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| U.S. Class: |
Current:
424/078.04;
Original:
424/078.04;
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| Field of Search: |
424/78.04
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| Priority Number: |
| 1994-10-26 |
US1994000329808 |
| 1993-11-12 |
US1993000152119 |
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| Abstract: |
A preservative-free ophthalmic composition useful in the treatment of conditions such as dry eye comprising an aqueous solution of hydroxypropyl methylcellulose, polyethylene glycol, dextrose, potassium chloride, boric acid and sodium borate decahydrate.
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| Attorney, Agent or Firm: |
Roberts, Edward McC. ;
Meece, R. Scott ;
Lee, Michael U. ;
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| Primary / Asst. Examiners: |
Kulkosky, Peter F.;
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| INPADOC Legal Status: |
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Family Legal Status Report
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| Parent Case: |
This application is a continuation-in-part of Ser. No. 08/152,119, filed on Nov. 12, 1993, now abandoned.
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| Designated Country: |
AM AP BB BG BR BY CN CZ EE EP FI GE HU JP KG KP KR KZ LK LR LT LV MD MG MN NO NZ OA PL RO RU SI SK TJ TT UA US
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| Family: |
Show 6 known family members
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First Claim:
Show all 24 claims |
What is claimed is:
1. An preservative-free ophthalmic composition, comprising:
- (a) about 0.20 to 2.5 weight percent of hydroxyalkyl cellulosic; polymer and from about 0.5 to 2.0 weight percent polyalkylene glycol;
- (b) a non-ionic tonicity adjusting agent selected from the group consisting of mannitol, sorbitol, dextrose, sucrose, urea, glycerol, and mixtures thereof, in amount sufficient to generate a tonicity of about 50 to 350 milliosmols per kilogram (mOsmol/kg);
- (c) an ionic salt, selected from the group consisting of alkali metal halides, in an amount sufficient to approximate the salt concentration of the human tear fluid; and
- (d) an antimicrobial in an amount sufficient to generate sufficient borate to maintain or reduce microbial concentrations for a period of 12 hours to 72 hours.
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| Background / Summary: |
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| Drawing Descriptions: |
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| Description: |
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| Forward References: |
Show 8 U.S. patent(s) that reference this one
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| Foreign References: |
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| Other Abstract Info: |
CHEMABS 123(10)123199N
DERABS C95-193887
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| Other References: |
Abstract of EP 473159 WPI Mar. 1992 Oshio et al.
Yassa, Dawoud, "Suspension containing Steroids", Journal, p. 422.
Yamamoto, Yujiro, "High-viscosity liquid for protection during surgery".
Search Report dated Aug. 13, 1993: Patents on Lubricating Eye Drops or Artificial Tears.
Equivalents Search dated Aug. 17, 1993.
Moneva et al., "Study of gel formation in solutions of polyvinyl alcohol containing boric acid", Colloid Jnl. of USSR #1, vol. 52, pp. 132-135 (1990).
(4 pages)
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