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 Title: |
US5601839:
Triacetin as a penetration enhancer for transdermal delivery of a basic drug
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Quan, Danyi; Salt Lake City, UT
Deshpanday, Ninad A.; Salt Lake City, UT
Venkateshwaran, Srinivasan; Salt Lake City, UT
Ebert, Charles D.; Salt Lake City, UT
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| Assignee: |
TheraTech, Inc., Salt Lake City, UT
other patents from THERATECH INC. (571645) (approx. 36)
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| Published / Filed: |
1997-02-11
/ 1995-04-26
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| Application Number: |
US1995000429757
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| IPC Code: |
Advanced:
A61K 9/00;
A61K 9/70;
A61K 31/137;
A61K 31/138;
A61K 31/167;
A61K 31/216;
A61K 31/404;
A61K 31/4458;
A61K 31/46;
A61K 31/485;
A61K 31/5415;
A61K 31/55;
A61K 47/10;
A61K 47/14;
A61K 47/30;
A61K 47/32;
A61P 9/00;
A61P 9/06;
A61P 21/02;
A61P 23/02;
A61P 25/04;
A61P 25/24;
A61P 25/26;
A61P 27/02;
Core:
A61K 31/403;
A61P 21/00;
A61P 23/00;
A61P 25/00;
A61P 27/00;
more...
IPC-7:
A61F 13/02;
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| ECLA Code: |
A61K9/00M3; A61K9/70E; A61K47/14;
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| U.S. Class: |
Current:
424/448;
424/449;
514/946;
Original:
424/448;
424/449;
514/946;
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| Field of Search: |
424/448,449
514/946
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| Priority Number: |
| 1995-04-26 |
US1995000429757 |
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| Abstract: |
A composition and method for enhancing transdermal penetration of a basic drug are described. The composition comprises a matrix patch comprising an effective amount of a basic drug, preferably having a pKa of about 8.0 or greater, an effective amount of penetration enhancer consisting essentially of triacetin, and a polymer later preferably comprising a pressure-sensitive adhesive. A preferred basic drug is oxybutynin and acid addition salts thereof. The method for enhancing transdermal penetration comprises applying the matrix patch to a selected area of skin.
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| Attorney, Agent or Firm: |
Thorpe, North & Western, LLP ;
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| Primary / Asst. Examiners: |
Phelan, D. Gabrielle;
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| INPADOC Legal Status: |
Show legal status actions
Family Legal Status Report
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| Designated Country: |
AL AM AP AZ BB BG BR BY CZ EE GE HU IS KE KG KP KZ LK LR LS LT BE CH FI FR GB GR IE IT LI
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| Family: |
Show 32 known family members
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First Claim:
Show all 22 claims |
We claim:
1. A method of enhancing the rate of transdermal penetration of a basic drug having a pKa of about 8.0 or greater comprising applying to a selected application situs a matrix patch comprising
- (a) a biocompatible polymer layer, wherein said biocompatible polymer is an adhesive selected from the group consisting of acrylics, vinyl acetates, natural and synthetic rubbers, ethylenevinylacetate copolymers, polysiloxanes, polyacrylates, polyurethanes, plasticized polyether block amide copolymers, plasticized styrene-rubber block copolymers, and mixtures thereof;
- (b) an effective amount of a percutaneously absorbable basic drug having a pKa of about 8.0 or greater selected from the group consisting of oxybutynin, scopolamine, fluoxetine, epinephrine, morphine, hydromorphone, atropine, cocaine, buprenorphine, chlorpromazine, imipramine, desipramine, methylphenidate, methamphetamine, lidocaine, procaine, pindol, nadolol, carisoprodol, and acid addition salts thereof; and
- (c) an effective amount of a permeation enhancer consisting essentially of triacetin.
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| Background / Summary: |
Show background / summary
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| Drawing Descriptions: |
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| Description: |
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| Forward References: |
Show 31 U.S. patent(s) that reference this one
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