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 Title: |
US5750397:
Human hematopoietic stem cell
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Tsukamoto, Ann; Palo Alto, CA
Baum, Charles M.; Mountain View, CA
Aihara, Yukoh; Yokohama, Japan
Weissman, Irving; Palo Alto, CA
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| Assignee: |
Systemix, Inc., Palo Alto, CA
other patents from SYSTEMIX, INC. (557315) (approx. 45)
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| Published / Filed: |
1998-05-12
/ 1995-06-06
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| Application Number: |
US1995000469453
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| IPC Code: |
Advanced:
C12N 5/06;
C12N 5/08;
G01N 33/569;
A61K 35/12;
A61K 38/00;
Core:
more...
IPC-7:
C12N 5/00;
C12N 5/02;
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| ECLA Code: |
C12N5/06B11P; G01N33/569H2;
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| U.S. Class: |
Current:
435/372;
435/366;
435/372.1;
435/372.2;
435/372.3;
435/404;
Original:
435/372;
435/366;
435/372.1;
435/372.2;
435/372.3;
435/404;
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| Field of Search: |
435/240.2,240.25,240.21,240.1,240.3,2,325,366,372,372.1-372.3,404
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| Priority Number: |
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| Abstract: |
Human hematopoietic stem cells are provided by separation of the stem cells from dedicated cells. The stem cells may than be maintained by regeneration in an appropriate growth medium. Means are provided for assaying for the stem cells as to their capability for producing members of each of the hematopoietic lineages.
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| Attorney, Agent or Firm: |
Sherwood, Pamela J.Bozicevic & Reed LLP ;
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| Primary / Asst. Examiners: |
Lankford, Jr., Leon B.; Tate, Christopher R.
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| INPADOC Legal Status: |
None
Family Legal Status Report
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| Parent Case: |
CROSS-REFERENCE TO RELATED APPLICATIONS
This is a divisional of application Ser. No. 07/720,883 filed Jun. 25, 1991 which is a continuation-in-part of application Ser. No. 502,616, filed Mar. 30, 1990 now issued as U.S. Pat. No. 5,061,620.
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| Designated Country: |
AT BE CH DE DK ES FR GB GR IT LI LU NL SE
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| Family: |
Show 24 known family members
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First Claim:
Show all 7 claims |
What is claimed is:
1. A culture comprising:
- human hematopoietic stem cells having fewer than 5% lineage committed cells, wherein said human stem cells are Thy-1+, CD34+, capable of self regeneration, and capable of differentiation to members of the lymphoid, erythroid and myelomonocytic lineages; and
- a medium capable of supporting the growth of said stem cells.
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| Background / Summary: |
Show background / summary
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| Drawing Descriptions: |
Show drawing descriptions
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| Description: |
Show description
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| Forward References: |
Show 20 U.S. patent(s) that reference this one
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| Foreign References: |
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| Other Abstract Info: |
DERABS C1998-296773
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| Other References: |
Whitlock and Witte, "Long-Term Culture of B Lymphocytes and Their Precursors From Murine Bone Marrow", P.N.A.S. USA (1982), 79:3608-3612.
(5 pages)
Cited by 23 patents
Berman and Basch, "Thy-1 Antigen Expression by Murine Hematopoietic Precursor Cells", Exp. Hematol. (1985), 13:1152-1156.
(5 pages)
Cited by 3 patents
Goldschneider et al., "Demonstration of Thy-1 Antigen on Pluripotent Hemopoietic Stem Cells in the Rat", J. Exp. Med. (1978), 148:1351-1366.
(16 pages)
Cited by 3 patents
Muller-Sieburg et al., "Isolation of Two Early B Lymphocyte Progenitors from Mouse Marrow: A Committed Pre-Pre-B Cell and a Clonogenic Thy-1Io Hematopoietic Stem Cell", Cell (1986), 44:653-662.
(10 pages)
Cited by 6 patents
Gisler et al., "Functional Maturation of Murine B Lymphocyte Precursors, II. Analysis of Cells Required from the Bone Marrow Microenvironment", J. of Immun. (1987), 138:2433-2438.
(6 pages)
Cited by 4 patents
Jordan and Lemischka, "Clonal and Systemic Analysis of Long-Term Hematopoiesis in the Mouse", Genes and Development (1990), 4:220-232.
(13 pages)
Cited by 3 patents
Smith et al., "Inhibition of Pluripotential Embryonic Stem Cell Differentation by Purified Polypeptides", Nature (1988), 336:688-690.
(3 pages)
Cited by 19 patents
Spangrude, "Enrichment of Murine Haemopoietic Stem Cells: Diverging Roads", Immun. Today (1989), 10:344-350.
(7 pages)
Cited by 14 patents
Muller-Sieburg et al., "Proliferation and Differentation of Highly Enriched Mouse Hematopoietic Stem Cells and progenitor Cells in Response to Defined Growth Factors", J. Exp. Med. (1988), 167:1825-1840.
(16 pages)
Cited by 5 patents
Lewinsohn et al., "Hematopoietic Progenitor Cell Expression of the H-CAM (CD44) Homing-Associated Adhesion Molecule", Blood (1990), 75:589-595.
(7 pages)
Cited by 7 patents
Whitlock et al., "Bone Marrow Stromal Cell Lines with Lymphopoietic Activity Express high Levels of a Pre-B Neoplasia-Associated Molecule", Cell (1987), 48:1009-1021.
(13 pages)
Cited by 35 patents
Lu et al., "Characterization of Adult Human Marrow Hematopoietic Progenitors Highly Enriched by Two-Color Cell Sorting With MY10 and Major Histocompatibility Class II Monoclonal Antibodies", J. of Immun. (1987), 139:1823-1829.
Broxmeyer et al. Effect of murine mast cell growth factor (c-kit . . . ligand) . . . Blood vol. 77 (10), May 1991, pp. 2142-2149.
(8 pages)
Cited by 11 patents
[ISI abstract]
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