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 Title: |
US5763415:
Destruction of the epithelium of an exocrine gland in the prophylactic and therapeutic treatment of cancer
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Sukumar, Saraswati Vaidyanathan; Columbia, MD
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| Assignee: |
John Hopkins University School of Medicine, Baltimore, MD
other patents from JOHNS HOPKINS UNIVERSITY (295920) (approx. 931)
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| Published / Filed: |
1998-06-09
/ 1996-08-02
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| Application Number: |
US1996000692001
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| IPC Code: |
Advanced:
A61K 35/76;
A61K 38/19;
A61K 38/45;
A61K 48/00;
Core:
A61K 35/66;
A61K 38/43;
more...
IPC-7:
A61K 48/00;
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| ECLA Code: |
A61K35/76; A61K38/19B; A61K38/45+M; K61K48/00; M12N710/19A;
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| U.S. Class: |
Current:
514/044.R;
424/093.1;
424/093.21;
435/069.1;
435/235.1;
435/325;
514/002;
Original:
514/044;
514/044;
514/002;
424/093.21;
424/093.1;
435/235.1;
435/325;
435/069.1;
435/172.3;
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| Field of Search: |
514/002,44
424/93.1,93.21
435/325,69.1,172.3,235.1
935/062,71,33,52,55,56,57
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| Government Interest: |
The invention disclosed in this application was made with government support under NIH planning grant P20 CA/ES66205, "Gene-mediated prevention Cancer, " and grant NIH 1RO1 CA 57993, "Genetic and hormonal factors in mammary carcinogenesis, " awarded by the National Institutes of Health, and with support of the American Cancer Society under grant RD388, "Targeted disruption of breast cells: a novel strategy for cancer prevention." Therefore, the government has certain rights in this invention.
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| Priority Number: |
| 1996-08-02 |
US1996000692001 |
| 1995-08-03 |
US1995000028929P |
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| Abstract: |
The present invention provides prophylactic and therapeutic methods of treating the ductal epithelium of an exocrine gland, in particular a mammary gland, for disease, in particular cancer. The methods comprise contacting the ductal epithelium of the exocrine gland with an epithelium-destroying agent, preferably by ductal cannulation, so as to realize a prophylactic or therapeutic effect.
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| Attorney, Agent or Firm: |
Leydig, Voit & Mayer, Ltd. ;
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| Primary / Asst. Examiners: |
Low, Christopher S. F.; Nguyen, Dave T.
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| INPADOC Legal Status: |
Show legal status actions
Family Legal Status Report
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| Parent Case: |
This application claims benefit of U.S. provisional application No. 60/028,929, filed Aug. 3, 1995, which is a conversion of U.S. patent application Ser. No. 08/510,623, which was filed on Aug. 3, 1995.
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| Designated Country: |
AU CA EP JP
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| Family: |
Show 17 known family members
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| Claim |
What is claimed is:
1. A method of treating the ductal epithelium of a mammary gland prophylactically for cancer, which method comprises the step of contacting, by ductal cannulation, the ductal epithelium of the mammary gland , which is tumor-free but is at risk for developing into a solid tumor, with the combination of (i) a vector, which comprises a gene encoding a thymidine kinase that can phosphorylate ganciclovir, and (ii) ganciclovir; so as to inhibit the formation of cancer of ductal epithelial origin.
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| Background / Summary: |
Show background / summary
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| Drawing Descriptions: |
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| Description: |
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| Forward References: |
Show 13 U.S. patent(s) that reference this one
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| Foreign References: |
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| Other Abstract Info: |
CHEMABS 126(17)229617Z
CHEMABS 129(04)036443T
CHEMABS 129(04)036443T
DERABS C1997-154039
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| Other References: |
Berchem et al., Cancer Research, 55:735-738 (Feb. 15, 1995).
(4 pages)
Cited by 7 patents
[ISI abstract]
Bieche et al., Cancer Research, 54:4274-4276 (Aug. 15, 1994).
(3 pages)
Cited by 5 patents
[ISI abstract]
Chen et al., Proc. Natl. Acad. Sci. USA, 91:3054-3057 (Apr. 1994).
(4 pages)
Cited by 48 patents
[ISI abstract]
Fujiwara et al., Current Opinion in Oncology, 6:96-105 (1994).
Hanby et al., Proc. Annu. Meet. Am. Assoc. Cancer Res., 35:A1085 (1994).
Haran et al., Cancer Research, 54:5511-5514 (Nov. 1, 1994).
(4 pages)
Cited by 9 patents
[ISI abstract]
Manome et al., Cancer Research, 54:5408-5413 (Oct. 15, 1994).
(6 pages)
Cited by 14 patents
[ISI abstract]
Miyadera et al., Cancer Research, 55:1687-1690 (Apr. 15, 1995).
(4 pages)
Cited by 7 patents
[ISI abstract]
Osaki et al., Cancer Research, 54:5258-5261 (Oct. 15, 1994).
(4 pages)
Cited by 18 patents
[ISI abstract]
Pansera, Medical Hypotheses, 33:107-111 (1990).
(5 pages)
Cited by 11 patents
Pitts, Molecular Carcinogenesis, 11:127-130 (1994).
(4 pages)
Cited by 8 patents
[ISI abstract]
Frykberg et al., "Overview of the Biology and Management of Ductal Carcinoma in Situ of the Breast," Database Medline, File Server Stn Karlsruhe, Abstract 94273121 (1994).
Russo et al., "Biology of Disease. Comparative Study of Human and Rat Mammary Tumorigenesis," Laboratory Investigation, vol. 62, pp. 244-278 (1990).
(35 pages)
Cited by 8 patents
Tamaki et al., "A Human Monoclonal Antibody Derived from Axillary Lymph Nodes of a Breast Cancer Patient," Hybridoma, vol. 8, pp. 293-302 (1989).
(10 pages)
Cited by 7 patents
Tamm et al., "Interleukin 6 Decreases Cell-Cell Association and Increases Motility of Ductal Breast Carcinoma Cells," The Journal of Experimental Medicine, vol. 170, pp. 1649-1669 (Nov., 1989).
(21 pages)
Cited by 7 patents
Zenklusen et al., "The Immunohistochemical Reactivity of a New Anti-Epithelial Monoclonal Antibody (MAb b-12) Against Breast Carcinoma and Other Normal and Neoplastic Human Tissues," Virchows Archiv A Pathological Anatomy and Histopathology, vol. 413, pp. 3-10 (1988).
(8 pages)
Cited by 7 patents
Orkin et al. Report and Recomendations . . . Gene Therapy. NIHPress. Dec. 7, 1995. p. 1-40.
Miller et al. FASEB. vol. 9 :190-199, Feb. 1995.
(10 pages)
Cited by 200 patents
[ISI abstract]
Marshall. Science.269:1050-1055, Aug. 1995.
(6 pages)
Cited by 503 patents
[ISI abstract]
Culver et al. TIG. 10(5):174-178, May 1994.
Hodgson. Exp Opin Ther. Patents. 5(5):459-468, 1995.
LaFont et al. The Lancet. 346: 1442-1443, Dec. 1995.
(2 pages)
Cited by 28 patents
[ISI abstract]
Friedmann Cancer (supp) vol.70(6):1810-1816, Sep. 1992.
(8 pages)
Cited by 39 patents
[ISI abstract]
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| Continuity Data: |
| Application Number | Filed | Notes |
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US1996000692001 | 1996-08-02 | is a
related to the prior publication |
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US20020035356A1 issued 2002-03-21 Prophylactic and therapeutic treatment of the ductal epithelium of a mammary gland for cancer
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US1996000692001 | 1996-08-02 | is a
related to the prior publication |
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US20050281780A1 issued 2005-12-22 Prophylactic and therapeutic treatment of the ductal epithelium of a mammary gland for cancer
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US2006000467838 | 2006-08-28 | is a
continuation of |
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US2005000179322
| 2005-07-12 |
(pending)
[presumed granted]
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US7196070 issued 2007-03-27 Prophylactic and therapeutic treatment of the ductal epithelium of a mammary gland for cancer
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US2005000179322 | 2005-07-12 | is a
division of |
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US2001000971901
| 2001-10-05 |
(granted)
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US6932777 issued 2005-08-23 Prophylactic and therapeutic treatment of the ductal epithelium of a mammary gland for cancer
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11179322 | | is a
division of |
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US2001000971901
| 2001-10-05 |
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US6923777 issued 2005-08-02 Bandage cooling apparatus and method of using same
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US2001000971901 | 2001-10-05 | is a
division of |
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US1999000240206
| 1999-01-29 |
(pending)
[presumed granted]
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US6330472 issued 2001-12-11 DESTRUCTION OF THE EPITHELIUM OF AN EXOCRINE GLAND IN THE PROPHYLACTIC AND THERAPEUTIC TREATMENT OF CANCER
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|
|
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US2001000971901 | 2001-10-05 | is a
division of |
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US1999000240206
| 1999-01-29 |
(granted)
|
| |
US6330472 issued 2001-12-11 Prophylactic and therapeutic treatment of the ductal epithelium for a mammary gland for cancer
|
|
|
|
US2001000971901 | | is a
division of |
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US1999000240206
| 1999-01-29 |
|
| |
US6330472 issued 2001-12-11 Prophylactic and therapeutic treatment of the ductal epithelium for a mammary gland for cancer
|
|
|
|
US2000000746588 | 2000-12-21 | is a
division of |
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US1999000240206
| 1999-01-29 |
(pending)
[presumed granted]
|
| |
US6330472 issued 2001-12-11 DESTRUCTION OF THE EPITHELIUM OF AN EXOCRINE GLAND IN THE PROPHYLACTIC AND THERAPEUTIC TREATMENT OF CANCER
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|
|
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US1999000240206 | 1999-01-29 | is a
continuation of |
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US1998000093145
| 1998-06-08 |
(granted)
|
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US6153184 issued 2000-11-28 Destruction of the epithelium of an exocrine gland in the prophylactic and therapeutic treatment of cancer
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|
|
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US1999000240206 | | is a
continuation of |
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US1998000093145
| 1998-06-08 |
|
| |
US6153184 issued 2000-11-28 Destruction of the epithelium of an exocrine gland in the prophylactic and therapeutic treatment of cancer
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|
|
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US1998000093145 | 1998-06-08 | is a
division of |
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>US1996000692001<
| 1996-08-02 |
(granted)
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| |
US5763415 issued 1998-06-09 Destruction of the epithelium of an exocrine gland in the prophylactic and therapeutic treatment of cancer
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|
|
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US1998000093145 | | is a
division of |
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>US1996000692001<
| 1996-08-02 |
|
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US5763415 issued 1998-06-09 Destruction of the epithelium of an exocrine gland in the prophylactic and therapeutic treatment of cancer
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|
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US1996000692001 | 1996-08-02 | is a
non-provisional of provisional |
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US1995000028929P
| 1995-08-03 |
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