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 Title: |
US5874533:
HIV-2 envelope polypeptides
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Bannwarth, Wilhelm; Rheinfelden-Beuggen, Germany
Caspers, Patrick; Oberwil, Switzerland
Le Grice, Stuart; Basel, Switzerland
Mous, Jan; Giebenach, Switzerland
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| Assignee: |
Roche Diagnostic Systems, Inc., Branchburg, NJ
other patents from ROCHE DIAGNOSTIC SYSTEMS, INC. (710108) (approx. 18)
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| Published / Filed: |
1999-02-23
/ 1994-03-15
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| Application Number: |
US1994000213416
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| IPC Code: |
Advanced:
C07K 14/16;
A61K 38/00;
A61K 39/00;
Core:
C07K 14/005;
more...
IPC-7:
C07K 1/00;
C07K 14/00;
C07K 17/00;
G01N 33/53;
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| ECLA Code: |
C07K14/16D;
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| U.S. Class: |
Current:
530/350;
435/005;
435/007.1;
435/007.21;
530/395;
Original:
530/350;
530/395;
435/007.1;
435/005;
435/007.21;
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| Field of Search: |
530/350,395
435/7.1
424/089
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| Priority Number: |
| 1987-11-16 |
CH1987000004454 |
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| Abstract: |
Polypeptides which include at least one antigenic and/or immunogenic determinant of the envelope protein (env) of the HIV-2 virus and their production by recombinant DNA technology and the DNA sequences, expression vectors and transformed single-cell organisms used in this process are provided. A method for the detection of HIV antibodies or HIV viruses in human sera or in other biological fluids is also provided.
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| Attorney, Agent or Firm: |
Johnson, George W. ;
Rocha-Tramaloni, Patricia S. ;
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| Primary / Asst. Examiners: |
Smith, Lynette F.;
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| INPADOC Legal Status: |
Show legal status actions
Family Legal Status Report
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| Related Applications: |
| Application Number |
Filed |
Patent |
Pub. Date |
Title |
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| US1992000895977 | 1992-06-09 |
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| US1988000268322 | 1988-11-07 |
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| Parent Case: |
This is a continuation of application Ser. No. 07/895,977, filed Jun. 9, 1992 now abandoned which is a continuation of Ser. No. 07/268,322, filed Nov. 7, 1988 now abandoned.
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| Designated Country: |
BE CH FR GB IT LI NL SE
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| Family: |
Show 21 known family members
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First Claim:
Show all 5 claims |
What is claimed is:
1. A fusion polypeptide having the formula:
A--B--C,
A--C--B,
or
C--B--A
wherein
- A is an affinity peptide
- B is
SerAlaArgLeuAsnSerTrpGlyCysAlaPheArgGlnValCysHisThrThr ValProTrpValAsnAspSerLeuAlaProAspTrpAspAsnMetThrTrpGln GluTrpGluLysGlnValArgTyrLeuGluAlaAsnIleSerLysSerLeuGlu GlnAlaGlnGly,
and
- C is an HIV-1 polypeptide, the amino acid sequence of which comprises an antigenic or immunogenic determinant of at least one of an HIV-1 envelope protein or HIV-1 core protein.
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| Background / Summary: |
Show background / summary
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| Drawing Descriptions: |
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| Description: |
Show description
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| Foreign References: |
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| Other Abstract Info: |
CHEMABS 112(19)173631R
DERABS C1989-152252
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| Other References: |
Kyte and Doolittle, J. Mol. Biol. 157:105-132 (1982) "A Simple Method for Displaying the Hhydropathic Character of a Protein".
(28 pages)
Cited by 289 patents
Pauletti, et al., Anal. Biochem. 151:540-546 (1985) "Application of a Modified Computer Algorithm in Determining Potential Antigenic Determinants Asso. with the . . . ".
(7 pages)
Cited by 21 patents
Hopp and Woods, Proc. Natl. Acid. Sci. 78(6):3824-3828 (1981) "Prediction of Protein Antigentic Determinants from Amino Acid Sequences".
(5 pages)
Cited by 213 patents
Clavel, et al., Science 233:343-346 (1986) "Isolation of a New Human Retrovirus for West African Patients with AIDS".
(4 pages)
Cited by 82 patents
Clavel, et al., Nature 324:691-69 (1986) "Molecular Cloning and Polymorphism of the Human Immune Deficiency Virus Type 2".
(5 pages)
Cited by 51 patents
Guyader, et al., Nature 326:662-669 (1987) "Genome Organization and Transactivation of the Human Immunodeficiency Virus Type 2".
(8 pages)
Cited by 112 patents
Brun-Vezinet, et al., Lancet 1:128-132 (1987) "Lymphadenopathy--Asso. Virus Type 2 in AIDS and AIDS-related complex".
(5 pages)
Cited by 2 patents
Hochuli, et al., Biol. Chem. Hoppe-Seyler 368:748 (1987) "Alpha-alkyl Nitrilotriacetic Acid Adsorbants . . . ".
(1 pages)
Cited by 5 patents
Villarejo, et al., J. Bacteriol. 120:466-474 (1974) "Beta Galactosidase from Termination and Deletion Mutant Strains".
(9 pages)
Cited by 8 patents
Certa, et al., EMBO J.5(11):3051-3056 (1986) "Subregions of a Conserved Part of the HIV . . . ".
(6 pages)
Cited by 4 patents
Shoeman, et al., Anal. Biochem. 161:370-379 (1987) "Comparison of Recombinant Human Immunodeficiency . . . ".
(10 pages)
Cited by 21 patents
Cordonnier, et al, 1989, "Single Amino-acid changes in HIV envelope . . . " Nature 340:571-574.
(4 pages)
Cited by 8 patents
Pongor, 1987, "The Use of Structural Profiles . . . " Methods in Enzymology 154:450-473.
(24 pages)
Cited by 25 patents
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