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Title: US6066848: Parallel fluid electrospray mass spectrometer
[ Derwent Title ]


Country: US United States of America

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20 pages

 
Inventor: Kassel, Daniel B.; Del Mar, CA
Wang, Tao; San Diego, CA
Zeng, Lu; San Diego, CA

Assignee: CombiChem, Inc., San Diego, CA
other patents from COMBICHEM, INC. (741971) (approx. 7)
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Published / Filed: 2000-05-23 / 1998-11-03

Application Number: US1998000185450

IPC Code: Advanced: H01J 49/04; H01J 49/10; G01N 30/46; G01N 30/62; G01N 30/72;
Core: H01J 49/02; G01N 30/00; more...
IPC-7: H01J 49/10;

ECLA Code: H01J49/16E; S01N30/46E; S01N30/62M; S01N30/72L2D;

U.S. Class: Current: 250/288; 250/285;
Original: 250/288; 250/285;

Field of Search: 250/288,288 A,285

Priority Number:
1998-11-03  US1998000185450

Abstract:     A method of analyzing each of a plurality of fluid samples (11-16), comprising, simultaneously spraying a plurality fluid samples (11-16) from electrospray needle array (20) towards mass spectrometer (50); positioning blocking device (40) to block all but one (32-34) of fluid samples (31-34) from reaching mass spectrometer (50); moving electrospray needle array (20) and blocking device (40) relative to one another to permit at least two of the plurality of fluid samples (31, 32) to reach mass spectrometer (50) one at a time; and analyzing the mass spectrum of fluid samples (31, 32, 33, 34) sequentially reaching mass spectrometer (50). A system for analyzing the composition of each of a plurality of fluid samples (31-34), comprising, mass spectrometer (50); multi-head electrospray needle array (20) for spraying fluid samples (31-34) towards mass spectrometer (50); and blocking device (40) positioned between electrospray needle array (20) and mass spectrometer (50), blocking device (40) dimensioned to block all but one (32-34) of fluid sample electrosprays (31-34) from reaching mass spectrometer (50).

Attorney, Agent or Firm: Townsend & Townsend & Crew LLP ;

Primary / Asst. Examiners: Berman, Jack;

Maintenance Status: E1 Expired  Check current status

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Parent Case:     This application is a Continuation of application Ser. No. 60/088,665, filed on Jun. 9, 1998, which is incorporated herein by reference for all purposes.

Designated Country: AE AL AM AP AT AZ BA BB BG BR BY CA CH CN CU CZ DE DK EA EE EP ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR 

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First Claim:
Show all 28 claims
What is claimed is:     1. A method of analyzing each of a plurality of fluid samples, comprising,
  • simultaneously electrospraying a plurality of fluid samples from an electrospray needle array towards a mass spectrometer;
  • positioning a blocking device to block all but one of the fluid samples from reaching the mass spectrometer;
  • moving the electrospray needle array and blocking device relative to one another to permit the plurality of fluid samples to reach the mass spectrometer one at a time; and
  • analyzing the mass spectrum of the plurality of fluid samples.


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Forward References: Show 106 U.S. patent(s) that reference this one

       
U.S. References: Go to Result Set: All U.S. references   |  Forward references (106)   |   Backward references (9)   |   Citation Link

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Patent  Pub.Date  Inventor Assignee   Title
Get PDF - 5pp US2534181* 1950-12 Roberts    
Get PDF - 31pp US3802782  1974-04 Natelson  Rohe Scientific Corporation CHEMICAL ANALYZER PERFORMING SEQUENTIAL ANALYSIS OF SAMPLES
Get PDF - 13pp US4004150  1977-01 Natelson   Analytical multiple component readout system
Get PDF - 6pp US4051731  1977-10 Bohl et al.  Bailey Meter Company Fluid sampling system
Get PDF - 7pp US4840074  1989-06 Jessop  VG Instruments Group Limited Multi-stream fluid sampling valve
Get PDF - 25pp US5288514  1994-02 Ellman  The Regents of the University of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
Get PDF - 59pp US5449902  1995-09 Onishi et al.  Hitachi, Ltd. Apparatus for directly coupling analytical column with mass spectrometer
Get PDF - 11pp US5668370  1997-09 Yano et al.  Hitachi, Ltd. Automatic ionization mass spectrometer with a plurality of atmospheric ionization sources
Get PDF - 11pp US5756994  1998-05 Bajic  Micromass Limited Electrospray and atmospheric pressure chemical ionization mass spectrometer and ion source
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Foreign References:
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Publication Date IPC Code Assignee   Title
Get PDF - 36pp WO9856028 1998-12  H01J 49/04 ARQULE INC AN AUTOMATED, HIGH THROUGHPUT METHOD FOR SCREENING A PLURALITY OF COMPOUNDS USING MASS SPECTROMETRY 
Get PDF - 121pp WO9913492 1999-03  H01J 49/26 ANALYTICA OF BRANFORD INC MULTIPLE SAMPLE INTRODUCTION MASS SPECTROMETRY 


Other Abstract Info: CHEMABS 132(03)030067P DERABS G2000-126501

Other References:
  • Xue et al., "Multichannel Microchip Electrospray Mass Spectrometry", Analytical Chemistry, vol. 69, No. 3, Feb. 1, 1997, pp. 426-430. (5 pages) Cited by 62 patents [ISI abstract]
  • De Biasi, Verner et al., High Throughput Liquid Chromatography/Mass Spectrometric Analyses using a Novel Multiplexed Electrospray Interface, Rapid Communications In Mass Spectrometry, 13, 1-4 (1999).
  • Printed Materials from http://www.micromass.co.uk --Press Centre--Pittcon '99 Press Releases: Announcing the World's First Parallel LC-MS! ...Micromass'LCT.TM. with MUX-Technology.TM.(with image) (/pprl.htm).
  • Printed Materials from http://www.micromass.co.uk --Drug Discovery (with image) (/pharm4.htm).
  • Printed Materials from http//www.micromass.co.uk --News in brief (with image) (/asmsag.htm).
  • Printed Materials from http://www.micromass.co.uk --Press Centre --Pittcon '99 Press Releases: New--Products: (/ppr.htm).
  • MicroMass Brochure: LCT.TM. with MUX-technology.TM. shows excellent chromatographic integrity for all four channels with negligible inter-channel cross-talk.
  • R. Loo, H. Udseth, and R. Smith, "Evidence of Charge Inversion in the Reaction of Singly Charged Anions with Multiply Charged Macroions", The Journal of Physical Chemistry, vol. 95, No. 17, 1991, pp. 6412-6415. (4 pages) Cited by 3 patents [ISI abstract]
  • A. Rulison and R. Flagan, "Scale-Up Electrospray Atomization Using Linear Arrays of Taylor Cones", Rev. Sci. Instr., vol. 64, No. 3, Mar. 1993, pp. 683-686. (4 pages) Cited by 8 patents [ISI abstract]
  • R. Kostiainen and A. Bruins, "Effect of Multiple Sprayers on Dynamic Range and Flow Rate Limitations in Electrospray and Ionspray Mass Spectrometry", Journal of Mass Spectrometry, 1994, pp. 549-558. (10 pages) Cited by 9 patents [ISI abstract]
  • "JMS Letters", Journal of Mass Spectrometry, vol. 32, pp 247-250, 1997.
  • P. Coffey, "Parallel Purification for Combinatorial Chemistry", Laboratory Automation News, vol. 2, No. 2, May 1997, pp. 6-14.
  • L. Zeng, L. Burton, K. Yung, B. Shushan, D.B. Kassel, "Automated Analytical/Preparative High-Performance Liquid Chromatography-Mass Spectrometry System for the Rapid Characterization and Purification of Compound Libraries", Journal of Chromatography A., 794 (1998) pp. 3-13. (11 pages) Cited by 30 patents [ISI abstract]
  • R. Stevenson, "The World of Separation Science: LabAutomation '98 Features Latest Developments in Combinatorial Chemistry and High-Throughput Screening", American Laboratory News, Mar. 1998, 7 pages.
  • L. Zeng, X. Wang, T. Wang, and D. B. Kassel, "New Developments in Automated PrepLCMS Extends the Robustness and Utility of the Method for Compound Library Analysis and Purification", Combinatorial Chemistry and High Throughput Screening, published Jun. 1, 1998 pp. 1-31.


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