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Title: US7006676: Method and apparatus for detecting an abnormality within a host medium utilizing frequency-swept modulation diffusion tomography
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Country: US United States of America

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Inventor: Zeylikovich, Iosif Semen; Charlotte, NC, United States of America
Klibanov, Michael Victor; Charlotte, NC, United States of America
Kharisov, Andrey Anatolyevich; Charlotte, NC, United States of America

Assignee: Medical Optical Imaging, Inc., Charlotte, NC, United States of America
other patents from Medical Optical Imaging, Inc. (868522) (approx. 1)
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Published / Filed: 2006-02-28 / 2000-03-17

Application Number: US2000000531262

IPC Code: Advanced: A61B 1/06; A61B 5/00; A61B 5/145; A61B 5/1455; A61B 6/00; A61B 10/00; G01N 21/17; G01N 21/35; G01N 21/47; G06K 9/00; G06T 1/00; H01S 3/10;
Core: G01N 21/31; more...

ECLA Code: A61B5/00P2; G01N21/47S;

U.S. Class: 382/131; 600/160; 372/028;

Field of Search: 382/131,128,129,130,132,133 600/473,476,160,180 378/037 356/320,323 372/028

Government Interest: GOVERNMENT LICENSE RIGHTS
    The U.S. Government may have rights in this invention as provided for by the terms of SBIR Grant No. DMS-9704923 awarded by the National Science Foundation.

Priority Number:
2000-03-17  US2000000531262

Abstract:     Methods and apparatus are provided for detecting an abnormality in a host medium, such as a tumor within a patient's breast. The host medium is initially illuminated at a plurality of different positions with light of at least two different wavelengths. Following the propagation of the signals through the host medium, the amplitude and phase of the signals are detected and, based upon the detected signals, a shadow image can be created in which the abnormality is depicted as a suspicious region. Once a suspicious region has been identified, at least that portion of the host medium that contains the suspicious region is again illuminated with frequency-swept modulated signals of at least two different wavelengths generated by the light source and modulated by a modulator, such as a network analyzer. Based upon the detected signals that have propagated through at least that portion of the host medium that includes the suspicious region, a P-criteria can be determined that is dependent upon the coefficient of absorptivity of the host medium and embedded abnormalities. Likewise, an Svar-criteria can be determined based upon concentrations of oxygenated hemoglobin and deoxygenated hemoglobin. Based upon at least these criteria which reflect physiological parameters of the host medium and embedded abnormalities as well as the possible comparison of the shadow images to an x-ray image of the host medium, the abnormality can be characterized. In addition, an apparatus is provided that facilitates the compression of a patient's breast in order to improve the resulting images.

Attorney, Agent or Firm: Alston & Bird LLP ;

Primary / Asst. Examiners: Mancuso, Joseph; Patel, Shefali

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Parent Case: RELATED APPLICATIONS
    The present application claims priority from U.S. Provisional Application No. 60/177,335 filed Jan. 21, 2000, the contents of which are incorporated herein.

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First Claim:
Show all 30 claims
    1. A method for detecting an abnormality in a host medium comprising:

illuminating the host medium at a plurality of different positions with frequency-swept modulated signals;

detecting signals following propagation through the host medium and the abnormality within the host medium;

creating a shadow image based upon the detected signals in which the abnormality is depicted as a suspicious region;

illuminating at least that portion of the host medium that contains the suspicious region with frequency-swept modulated signals, following creation of the shadow image, wherein the signals are frequency-swept modulated across a larger range of frequencies during the illumination of the suspicious region than during the initial illumination of the host medium;

detecting the frequency-swept modulated signals following propagation through at least that portion of the host medium that contains the suspicious region; and

characterizing the abnormality based upon the detected frequency-swept modulated signals.



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  • Continuity Data:
    Application Number Filed Notes

    US2000000531262 2000-03-17  is a non-provisional of provisional
    US2000000177335P  2000-01-21


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