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 Title: |
US7041451:
Electrochemiluminescence helicase assay
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Zhang, Litao; Collegeville, PA, United States of America
Harrison, Richard K; Glenmoore, PA, United States of America
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| Assignee: |
sanofi-aventis, Bridgewater, NJ, United States of America
other patents from SANOFI-AVENTIS (852956) (approx. 1)
News, Profiles, Stocks and More about this company
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| Published / Filed: |
2006-05-09
/ 2002-06-28
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| Application Number: |
US2002000187212
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| IPC Code: |
Advanced:
C07H 21/00;
C07H 21/02;
C07H 21/04;
C12N 15/09;
C12P 19/34;
C12Q 1/25;
C12Q 1/68;
G01N 33/15;
G01N 33/50;
G01N 33/53;
G01N 33/532;
G01N 33/553;
G01N 33/566;
Core:
C12P 19/00;
G01N 33/551;
more...
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| ECLA Code: |
C12Q1/68B2H+563/107+521/513;
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| U.S. Class: |
435/006;
435/091.1;
435/091.2;
536/023.1;
536/024.3;
536/024.31;
536/024.32;
536/024.33;
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| Field of Search: |
435/006,91.1,91.2
536/23.1,24.3,24.31,24.32,24.33
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| Priority Number: |
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| Abstract: |
The present invention relates to electrochemiluminescent assays for detecting helicase activity. The invention provides a helicase assay that is rapid, sensitive and suitable for high throughput screening for helicase inhibitors. Helicase inhibitors represent a class of pharmacological agents useful for the treatment of disease.
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| Attorney, Agent or Firm: |
Bell, Boyd & Lloyd PLLC ;
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| Primary / Asst. Examiners: |
Riley, Jezia;
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| INPADOC Legal Status: |
None
Family Legal Status Report
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| Foreign References: |
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| Other References: |
Mullins et al., Specific Synthesis of DNA in Vitro via a Polymerase-Catalyzed Chain Reaction, Methods in Enzymology, 155, 335-350 (1987).
Taylor et al., The Use of Phosphorothioate-Modified DNA In Restriction Enzyme Reactions to Prepare Nicked DNA, Nucleic Acids Research 13(24, 8749-8764 (1985).
(16 pages)
Cited by 34 patents
Saiki et al., Enzymatic Amplification of B-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia, Science, 230, 1350-1354 (1985).
(5 pages)
Cited by 384 patents
Roman et al., Characterization of the Helicase Activity of the Escherichia coli RecBCD Enzyme Using a Novel Helicase Assay, Biochemistry 28(7), 2863-2873 (1989).
(11 pages)
Cited by 3 patents
Kenten et al., Rapid Electrochemiluminescence Assays of Polymerase Chain Reaction Products, Clinical Chemistry 37(9), 1626-1632 (1991).
(7 pages)
Cited by 16 patents
[ISI abstract]
Kenten et al., Improved Electrochemiluminescent Label for DNA Probe Assays: Rapid Quantitative Assays of HIV-1 Polymerase Chain Reaction Products, Clinical Chemistry 38(6), 873-879 (1992).
(7 pages)
Cited by 14 patents
[ISI abstract]
Schutzbank et al., Detection of Human Immunodeficiency Virus Type 1 Proviral DNA by PCR Using an Electrochemiluminescence-Tagged Probe, Journal of Clinical Microbiology 33(8), 2036-2041 (1995).
(6 pages)
Cited by 4 patents
[ISI abstract]
Runyon et al., Eischerichia coli helicase II (UvrD) protein initiates DNA unwinding at nicks and blunt ends, Proc. Natl. Acad. Sci., 87, 6383-6387 (1990).
(5 pages)
Cited by 3 patents
Sanger et al., DNA sequencing with chain-terminating inhibitors, Proc. Natl. Acad. Sci. 74(12), 5463-5467 (1977).
(5 pages)
Cited by 947 patents
Matson, DNA Helicases of Escherchia coli, Progress in Nucleic Acid Research & Molecular Biology 40, 289-326 (1991).
(38 pages)
Cited by 2 patents
[ISI abstract]
Palas et al., Biochemical & Physical Characterization of Exonuclease V from Eschericha coli, The Journal of Biological Chemistry, 265(6), 3447-3454 (1990).
(8 pages)
Cited by 3 patents
Matson et al., The Gene 4 Protein of Bacteriophage T7, The Journal of Biological Chemistry 258(22), 14017-14024 (1983).
LeBowitz et al., The Escherichia coli dnaB Replication Protein Is a DNA Helicase, The Journal of Biological Chemistry 261(10), 4738-4748 (1986).
(11 pages)
Cited by 4 patents
Lohman et al., Mechanisms of Helicase-Catalyzed DNA Unwinding, Annu. Rev. Biochem. 65, 169-214 (1996).
(46 pages)
Cited by 2 patents
[ISI abstract]
Venkatesan et al., Bacteriophage T4 Gene 41 Protein, Required for the Synthesis of RNA Primers, Is Also a DNA Helicase, The Journal of Biological Chemistry, 257(20), 12426-12434 (1982).
Reha-Krantz et al., The dnaB Gene Product of Escherichia coli, The Journal of Biological Chemistry 253(11), 4043-4050 (1978).
(8 pages)
Cited by 2 patents
Matson et al., DNA Helicases: Enzymes with Essential Roles in All Aspects of DNA Metabolism, BioEssays 16(1), 13-22 (1994).
(10 pages)
Cited by 2 patents
[ISI abstract]
Li et al., Three new DNA helicases from Saccharomyces cerevisiae, Chromosoma 102, S93-S99 (1992).
(7 pages)
Cited by 2 patents
[ISI abstract]
Bruno, Broad applications of electrochemiluminescence technology to the detection and quantiation of microbiological, biochemical and chemical analytes, Recent Res. Devel. in Microbiology 1, 25-46 (1997).
Blackburn Gary F. et al., Electrochemiluminescence Detection for Development of Immunoassays and DNA Probe Assays for Clinical Diagnostics, Clin. Chem. 37(9):1534-1539 (1991).
(6 pages)
Cited by 49 patents
[ISI abstract]
Earnshaw David L. et al., Time-Resolved Fluorescence Energy Transfer DNA Helicase Assays for High Throughput Screening, Journal of Biomol. 4(5):239-247 (1999 ).
(10 pages)
Cited by 3 patents
[ISI abstract]
Kyono Kiyoshi et al., Detection of Hepatitis C Virus Helicase Activity Using the Scintillation Proximity Assay System, Analytical Biochemistry 257:120-126 (1998).
(7 pages)
Cited by 3 patents
[ISI abstract]
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| Continuity Data: |
| Application Number | Filed | Notes |
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US2002000187212 | 2002-06-28 | is a
related to the prior publication |
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>US2002000187212< | 2002-06-28 | is a
continuation of |
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US1999000410960
| 1999-10-05 |
(granted)
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US6448004 issued 2002-09-10 Electrochemiluminescence helicase assay
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>US2002000187212< | | is a
continuation of |
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US1999000410960
| 1999-10-05 |
|
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US6448004 issued 2002-09-10 Electrochemiluminescence helicase assay
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