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Title: EP0392377A2: Methods and devices for the separation of plasma or serum from whole blood, collection of plasma or serum, and reagent delivery system[German][French]
[ Derwent Title ]


Country:
Kind:
EP European Patent Office (EPO)
A2 APPLICATION PUBLISHED WITHOUT SEARCH REPORT i (See also: EP0392377A3, EP0392377B1 )

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33 pages

 
Inventor: Aunet, Diane L.;
Elmore, Kristin D.;
Georgevich, Gradimir G.;
Oosta, Gary M.;
Siegel, Neal A.;
Jeng, Tzyy-Wen;
Pry, Terry A.;
Silverman, Cathy R.;

Assignee: ABBOTT LABORATORIES
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Published / Filed: 1990-10-17 / 1990-04-06

Application Number: EP1990000106605

IPC Code: Advanced: B01D 39/00; B01D 39/16; B01D 39/18; B01D 39/20; B01L 3/00; C12M 1/12; C12M 1/34; C12Q 1/00; C12Q 1/26; C12Q 1/28; C12Q 1/44; C12Q 1/48; G01N 33/48; G01N 33/49; G01N 33/52; G01N 33/53;
IPC-7: B01D 39/00; G01N 33/49;

ECLA Code: B01L3/508; B01D39/00; B01D39/16B4B; B01D39/16D4B; B01D39/18; B01D39/20B2B; B01D39/20D2B; B01D39/20H2B; G01N33/49C; G01N33/52C2; G01N33/53B; L01L400/04F2;

Priority Number:
1989-04-07  US1989000335064
1990-03-27  US1990000499864
1990-03-27  US1990000499928

Abstract:     A device and method for permitting the separation of plasma or serum from whole blood. The device comprises a matrix of hydrophilic sintered porous material to which at least one red blood cell agglutinating agent has been applied. According to a first method of using the device, a sample of whole blood is applied to a first end of the matrix and the red blood cells within the sample come in contact with the agglutinating agents present in the matrix. The blood cells agglutinate, and are entrapped in the interstices of the matrix, while substantially blood-cell-free serum or plasma accumulates near the outlet of the device. A filter means in liquid receiving relationship with the matrix functions to wick the serum or plasma from the matrix. According to an alternative aspect of the invention, a filter means in liquid receiving relationship with the outlet of the matrix functions to retain any blood cells which pass through the matrix as the filter means wicks the plasma or serum from the matrix. Additional agglutinating agents may be incorporated within the filter means to facilitate retention of blood cells which pass through the matrix. Another aspect of the present invention involves a device for the measurement of a serum or plasma sample, utilizing a matrix of sintered porous material, such as sintered glass, sintered steel, sintered ceramics, sintered plastics, and eguivalents thereof. The matrix is characterized by a reproducible fluid uptake capacity proportional to the fixed dimensions of said matrix, a minimal reactivity with plasma or serum components, and a hydrophilic internal surface which enables the matrix to collect and retain a predetermined volume of sample for analysis. A further aspect of the present invention provides a porous reagent delivery system comprising a matrix of sintered porous material containing at least one reagent in a freeze-dried state, and method for making same. The system allows the delivery of a unitized form of a freeze-dried reagent which is recoverable upon contact with a liquid.

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Designated Country: AT BE CH DE ES FR GB IT LI NL

Family: Show 17 known family members

First Claim:
Show all claims
    1. A device for separating plasma or serum from whole blood comprising a matrix of hydrophilic sintered porous material in which at least one red blood cell agglutinating agent has been incorporated, said matrix being characterized by a pore size selected such that individual blood cells pass through said matrix but agglutinated blood cells are retained by said matrix.

Description
Expand description

    This application is a continuation-in-part of United States Patent Application Serial Number 335,064 filed April 7, 1989.
+ BACKGROUND OF THE INVENTION
+ Field of the Invention
+ Background
+ SUMMARY OF THE INVENTION
+ BRIEF DESCRIPTION OF THE FIGURES
+ DETAILED DESCRIPTION OF THE INVENTION
+ Example 1
+ Example 2
+ Example 3
+ Example 4
+ Example 5
+ Example 6
+ Example 7
+ Example 8
+ Example 9
+ Example 10
+ Example 11
+ Example 12
+ EXAMPLE 13
+ PREPARATION OF MATRICES CONTAINING GLUCOSE OXIDASE
+ EXAMPLE 14
+ PREPARATION OF MATRICES CONTAINING PEROXIDASE REAGENT
+ EXAMPLE 15
+ ASSAY FOR GLUCOSE
+ EXAMPLE 16
+ ASSAY FOR GLUCOSE
+ EXAMPLE 17
+ ASSAY FOR GLUCOSE
+ EXAMPLE 18
+ PREPARATION OF MATRICES CONTAINING CHOLESTEROL ESTER HYDROLASE AND CHOLESTEROL OXIDASE
+ EXAMPLE 19
+ EXAMPLE 20
+ PREPARATION OF MATRICES CONTAINING CHOLESTEROL REAGENTS
+ EXAMPLE 21
+ PREPARATION OF MATRICES CONTAINING PEROXIDASE/DCHBS REAGENTS
+ EXAMPLE 22
+ PREPARATION OF MATRICES CONTAINING GLYCEROL-PHOSPHATE OXIDASE AND GLYCEROL KINASE
+ EXAMPLE 23
+ PREPARATION OF MATRICES CONTAINING PEROXIDASE AND LIPASE
+ EXAMPLE 24
+ ASSAY FOR TRIGLYCERIDES

       
Forward References: Go to Result Set: Forward references (5)
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Other Abstract Info: DERABS C90-238464

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