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 Title: |
US4197291:
Hydrolytic enzyme material
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Klein, Gerold K. V.; Brunswick, ME 04011
Houck, John C.; Washington, DC
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| Assignee: |
Klein; Gerold K. V., Brunswick, ME
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| Published / Filed: |
1980-04-08
/ 1978-03-17
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| Application Number: |
US1978000887607
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| IPC Code: |
Advanced:
C12N 9/50;
A61K 38/00;
Core:
more...
IPC-7:
A61K 37/54;
C07G 7/022;
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| ECLA Code: |
C12N9/50; K61K38/00;
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| U.S. Class: |
Current:
424/094.65;
435/195;
435/212;
435/219;
Original:
424/094;
435/195;
435/212;
435/219;
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| Field of Search: |
195/062,66 R
424/094
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| Priority Number: |
| 1978-03-17 |
US1978000887607 |
| 1974-01-08 |
US1974000431622 |
| 1976-04-20 |
US1976000678695 |
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| Abstract: |
Disclosure relates to novel hydrolytic enzyme product derived from the pineapple plant useful for the digestion, dissection and separation of non-viable, devitalized tissue, especially eschar tissue from viable tissue in a mammalian host.
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| Attorney, Agent or Firm: |
Cooper, Dunham, Clark, Griffin & Moran ;
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| Primary / Asst. Examiners: |
Shapiro, Lionel M.;
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| INPADOC Legal Status: |
None
Family Legal Status Report
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| Parent Case: |
This is a continuation of application Ser. No. 678,695 filed Apr. 20, 1976, now abandoned which is a continuation-in-part of copending application Ser. No. 489,254 filed July 17, 1974 now abandoned, which in turn is a continuation of application Ser. No. 431,622 filed Jan. 8, 1974, now abandoned.
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| Family: |
Show 17 known family members
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First Claim:
Show all 8 claims |
What is claimed is:
1. An enzyme product obtainable from bromelain capable of debridement of devitalized tissue from a mammalian host which comprises a water soluble, heat labile protein free of caseinolytic activity having a peak isoelectric point of about 6, comprising at least two subunits, each subunit having a molecular weight of from about 14,300 to 15,000 daltons, with a characteristic absorption peak in the ultraviolet region of the spectrum at 280 nm.; the said product being active in the absence of sulfhydryl activation and in the presence of sulfhydryl deactivating quantities of phenylmercuric acetate, and the physiological acceptable alkali metal and acid addition salts thereof.
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| Background / Summary: |
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| Drawing Descriptions: |
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| Description: |
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| Forward References: |
Show 8 U.S. patent(s) that reference this one
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