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 Title: |
US4447356:
Conotoxins
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Olivera, Baldomero M.; Salt Lake City, UT 84105
Cruz, Lourdes J.; Sta Mesa, Manila, Philippines
Gray, William R.; Salt Lake City, UT 84117
Rivier, Jean E. F.; La Jolla, CA 92037
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| Assignee: |
None
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| Published / Filed: |
1984-05-08
/ 1982-06-04
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| Application Number: |
US1982000385125
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| IPC Code: |
Advanced:
C07K 7/08;
A61K 38/00;
Core:
C07K 7/00;
more...
IPC-7:
C07C 103/52;
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| U.S. Class: |
Current:
530/327;
530/857;
930/020;
930/021;
930/023;
930/260;
930/DIG.811;
Original:
260/112.5R;
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| Field of Search: |
260/112.5 R
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| Priority Number: |
| 1981-04-17 |
US1981000255237 |
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| Abstract: |
The present invention provides bioactive peptides of generic formula [Figure] These peptides are extremely potent inhibitors of synaptic transmission at the neuromuscular junction, while at the same time lacing demonstrable inhibition of either nerve or muscle action potential propagation. The peptides are termed conotoxins herein. Naturally occurring conotoxins include conotoxin GI, GIA and GII. In conotoxin GI, U is Glu, V4 is Asn, V5 is Pro, V6 is Ala, W is Gly, X is Arg, Y is His, Z is Tyr, V12 is Ser and R is --NH2. Conotoxin GIA is identical to GI except R is --Gly--Lys--NH2. Conotoxin GII is identical to GI except that V4 is His, Z is Phe, and X is Lys. Conotoxin MI is identical to GI except that U is Gly-Arg, X is Lys and Y is Asn.
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| Attorney, Agent or Firm: |
Keil & Witherspoon ;
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| Primary / Asst. Examiners: |
Phillips, Delbert R.;
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| Maintenance Status: |
E1 Expired Check current status
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| INPADOC Legal Status: |
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| Parent Case: |
This application is a continuation-in-part of application Ser. No. 255,237, filed Apr. 17, 1981, now abandoned.
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| Family: |
None
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First Claim:
Show all 15 claims |
What is claimed is:
1. A peptide having the structure [Figure] wherein U is --NH2, Glu, Asp, Gly--Arg, N-trimethyl Glu or N-trimethyl Asp,
- any of V4, V5 or V6 is Asn, His, Pro or Ala,
- V12 is Ser or Cys,
- W is Gly,
- X is Lys, Arg, ornithine, homoarginine, N-methyl lysine, dimethyl lysine or trimethyl lysine,
- Y is Asn, Phe, Tyr, nitrotyrosine, His, Trp, monoiodo His, or substituted Phe,
- Z is Leu, Val, Ile, Phe, Tyr, monoido Tyr, diiodo Tyr, monochloro-monoiodo Tyr, or cyclohexylalanine, and
- R is --NH2, --Gly--Lys--NH2.
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| Background / Summary: |
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| Drawing Descriptions: |
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| Description: |
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| Forward References: |
Show 34 U.S. patent(s) that reference this one
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