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Title: US4658021: Methionyl human growth hormone
[ Derwent Title ]

Country: US United States of America

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13 pages

 
Inventor: Goeddel, David V.; Burlingame, CA
Heyneker, Herbert L.; Burlingame, CA

Assignee: Genentech, Inc., So. San Francisco, CA
other patents from GENENTECH, INC. (218000) (approx. 2,164)
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Published / Filed: 1987-04-14 / 1984-09-25

Application Number: US1984000654340
IPC Code: Advanced: A61K 38/27; C07G 99/00; C07H 21/00; C07H 21/04; C07K 14/00; C07K 14/575; C07K 14/61; C12N 1/20; C12N 1/21; C12N 15/00; C12N 15/09; C12N 15/10; C12N 15/18; C12N 15/62; C12N 15/63; C12N 15/64; C12N 15/66; C12N 15/70; C12N 15/72; C12P 19/34; C12P 21/00; C12P 21/02; C12R 1/125; C12R 1/19; C12R 1/42; C12R 1/46;
Subclass: C12N;
C12P;
IPC-7:
C07K 15/06;
C12N 15/00;

ECLA Code: C12N15/66; C07K14/61; C12N15/10; C12N15/62; C12N15/70; M07K319/00; M07K319/02; M07K319/50; M07K319/75;

U.S. Class: Current: 530/399; 930/120;
Original: 530/399; 435/172.3; 935/013;

Field of Search: 435/172.3 935/013 260/112.5 R 530/399

Priority Number:
1984-09-25  US1984000654340
1979-07-05  US1979000055126

Abstract:     Described are methods and means for the construction and microbial expression of quasi-synthetic genes arising from the combination of organic synthesis and enzymatic reverse transcription from messenger RNA sequences incomplete from the standpoint of the desired protein product. Preferred products of expression lack bio-inactivating leader sequences common in eukaryotic expression products but problematic with regard to microbial cleavage to yield bioactive material. Illustrative is a preferred embodiment in which a gene coding for human growth hormone (useful in, e.g., treatment of hypopituitary dwarfism) is constructed and expressed.

Primary / Asst. Examiners: Tanenholtz, Alvin E.;

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Related Applications: Go to Result Set: 3 patent(s) that list this one as related
Application Number Filed Patent Pub. Date  Title
US1982000356564 1982-03-09    1986-07-22  Microbial expression of a gene for human growth hormone
US1979000055126 1979-07-05    1982-08-03  Method of constructing a replicable cloning vehicle having quasi-synthetic genes


       
Parent Case:     This application is a division of application Ser. No. 06/356,564, filed Mar. 9, 1982 now U.S. Pat. No. 4,601,980, which is a division of application Ser. No. 06/055,126, filed July 5, 1979, now U.S. Pat. No. 4,342,832.

Family: Show 171 known family members
Claim We claim:     1. Methionyl human growth hormone.

Background / Summary: Show background / summary

Drawing Descriptions: Show drawing descriptions

Description: Show description

Forward References: Show 37 U.S. patent(s) that reference this one

       
U.S. References: Go to Result Set: All U.S. references   |  Forward references (37)   |   Backward references (9)   |   Citation Link

Buy
PDF		 Patent  Pub.Date  Inventor Assignee   Title
Get PDF - 7pp US3853832  1974-12 Li  Harmone Research Foundation SYNTHETIC HUMAN PITUITARY GROWTH HORMONE AND METHOD OF PRODUCING IT
Get PDF - 11pp US3853833  1974-10 Li  Hormone Research Foundation SYNTHETIC HUMAN GROWTH-PROMOTING AND LACTOGENIC HORMONES AND METHOD OF PRODUCING SAME
Get PDF - 12pp US4110322  1978-08 Greven et al.  Akzona Incorporated Peptide derivatives and pharmaceutical compositions containing same
Get PDF - 35pp US4190495  1980-02 Curtiss, III  Research Corporation Modified microorganisms and method of preparing and using same
Get PDF - 10pp US4237224  1980-12 Cohen  Board of Trustees of the Leland Stanford Jr. University Process for producing biologically functional molecular chimeras
Get PDF - 4pp US4332892  1982-06 Ptashne  President and Fellows of Harvard College Protein synthesis
Get PDF - 13pp US4342832  1982-08 Goeddel  Genentech, Inc. Method of constructing a replicable cloning vehicle having quasi-synthetic genes
Get PDF - 24pp US4356270  1982-10 Itakwa  Genentech, Inc. Recombinant DNA cloning vehicle
Get PDF - 32pp US4363877  1982-12 Goodman et al.  The Regents of the University of California Recombinant DNA transfer vectors
       
Foreign References:
Buy
PDF		 Publication Date IPC Code Assignee   Title
Get PDF - 18pp EP0006694 1980-01  C12N 15/09 HARVARD COLLEGE Method of making a selected protein 
Get PDF - 27pp EP0009930 1980-04  C12N 15/00 THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY Recombinant DNA, method for preparing it and production of foreign proteins by unicellular hosts containing it 
Get PDF - 79pp EP0020251 1980-12  C12N 15/00 THE REGENTS OF THE UNIVERSITY OF CALIFORNIA DNA transfer vector, host transformed with it, vaccine, and their production 
Get PDF - 38pp EP0020147 1980-12  C12N 15/00 THE REGENTS OF THE UNIVERSITY OF CALIFORNIA A DNA transfer vector for human pre-growth hormone, a microorganism transformed thereby, and a method of cloning therefor 
Get PDF - 43pp EP0026598 1981-04  C12N 15/00 THE REGENTS OF THE UNIVERSITY OF CALIFORNIA DNA transfer vectors for human proinsulin and human pre-proinsulin, microorganisms transformed thereby, and processes involving such substances 
Buy PDF- 5pp GB2073245 1981-06  C07K 14/61 YEDA RES & DEV Production of Bovine Growth Hormone by Microorganisms 


Other Abstract Info: CHEMABS 094(21)170974D DERABS C81-03727D

Other References:
  • Freifelder, Molecular Biology, Science Books International, pp. 508-511, 1983.
  • The Merk Index, Tenth Edition pp. 1246 and 1247, 1983.
  • Backman et al., Cell, vol. 13, pp. 65-71 (Jan. 1978). (7 pages) Cited by 40 patents
  • Bolivar et al., Gene 2, pp. 95-113 (1977). (19 pages) Cited by 172 patents
  • Chang et al., Nature, vol. 275, pp. 617-624 (Oct. 1978). (8 pages) Cited by 120 patents
  • Crea et al., PNAS, vol. 75, pp. 5765-5769 (Dec. 1978).
  • Curtis et al., Molecular Cloning of Recombinant DNA, by Scott et al, pp. 99-111 (1977).
  • Goeddel et al., PNAS 76, pp. 106-110 (1979).
  • Goeddel et al., Nature, vol. 281, pp. 544-548 (Oct. 1979). (5 pages) Cited by 195 patents
  • Humphries et al., Nucleic Acids Res., 4(7) pp. 2389-2406 (1977). (18 pages) Cited by 20 patents
  • Itakura et al., Science, vol. 198, pp. 1056-1063 (Dec. 1977). (8 pages) Cited by 180 patents
  • Klenow et al., PNAS, vol. 65, pp. 168-175 (Jan. 1970).
  • Kornberg, DNA Synthesis, pp. 87-88, pub. by W. H. Freeman & Co. (1974).
  • Li et al., J. Amer. Chem. Soc., vol. 92, pp. 7608-7609 (1970).
  • Marians et al., Nature, vol. 263, pp. 744-748 (Oct. 1976). (5 pages) Cited by 14 patents
  • Martial et al., Science, vol. 205, pp. 456-461 (Jun. 12, 1980).
  • Maxam et al., PNAS, vol. 74, pp. 560-564 (Feb. 1977).
  • Newmark, Nature, vol. 280, pp. 637-638 (Aug. 23, 1979). (2 pages) Cited by 6 patents
  • Polisky et al., PNAS, 73:11, pp. 3900-3904 (1976).
  • Razin et al., PNAS vol. 75, pp. 4268-4270 (Sep. 1978).
  • Roberts et al., PNAS vol. 76, pp. 760-764 (Feb. 1979).
  • Seeburg et al., Nature vol. 276, pp. 795-798 (Dec. 1978). (4 pages) Cited by 36 patents
  • Shine et al., Nature, vol. 285, pp. 456-461 (Jun. 12, 1980). (6 pages) Cited by 27 patents
  • Sutcliff, Cold Spring Harbor Symposium, 43, pp. 70-90 (1978).
  • Ullrich et al., Science vol. 196, pp. 1313-1319 (1977).
  • Villa-Komaroff et al., PNAS vol. 75, pp. 3727-3731 (Aug. 1978).
  • Wickens et al., The Journal of Biological Chemistry, vol. 253, No. 7, pp. 2483-2495 (1978). (13 pages) Cited by 20 patents
  • Chemical Abstracts, vol. 88, p. 249 No. 101458c (Apr. 1978).
  • Chemical Abstracts, vol. 87:114458g (1977).
  • The Economist, pp. 87-88, Jul. 14, 1979.
  • Technology Review, pp. 12 and 13, Dec. 1976.
  • Time, Jul. 30, 1970, p. 70.
  • Olson et al., Nature 293, 408 (1981). (4 pages) Cited by 8 patents
  • Niall, H., Nature New Biology, vol. 230, 90 (1971). Cited by 7 patents


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