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 Title: |
US4898830:
Human growth hormone DNA
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Goeddel, David V.; Burlingame, CA
Heyneker, Herbert L.; Burlingame, CA
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| Assignee: |
Genentech, Inc., South San Francisco, CA
other patents from GENENTECH, INC. (218000) (approx. 2,164)
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| Published / Filed: |
1990-02-06
/ 1987-04-13
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| Application Number: |
US1987000037319
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| IPC Code: |
Advanced:
C07K 14/61;
C12N 15/10;
C12N 15/18;
C12N 15/62;
C12N 15/70;
IPC-7:
C12N 1/00;
C12N 15/00;
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| ECLA Code: |
C07K14/61; C12N15/10; C12N15/62; C12N15/70; M07K319/02; M07K319/50; M07K319/75;
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| U.S. Class: |
Current:
435/320.1;
536/023.5;
536/023.51;
536/023.7;
536/024.1;
Original:
435/320;
435/172.3;
935/013;
536/027;
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| Field of Search: |
435/172.3,320
935/013
536/027
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| Priority Number: |
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| Abstract: |
Described are methods and means for the construction and microbial expression of quasi-synthetic genes arising from the combination of organic synthesis and enzymatic reverse transcription from messenger RNA sequences incomplete from the standpoint of the desired protein product. Preferred products of expression lack bio-inactivating leader sequences common in eukaryotic expression products but problematic with regard to microbial cleavage to yield bioactive material. Illustrative is a preferred embodiment in which a gene coding for human growth hormone (useful in, e.g., treatment of hypopituitary dwarfism) is constructed and expressed.
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| Attorney, Agent or Firm: |
Buting, Walter E. ;
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| Primary / Asst. Examiners: |
Tanenholtz, Alvin E.;
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| INPADOC Legal Status: |
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Family Legal Status Report
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| Parent Case: |
This application is a continuation of application Ser. No. 06/654,340, filed Sept. 25, 1984 now U.S. Pat. No. 4,658,021, which is a division of application Ser. No. 06/356,564 filed Mar. 9, 1982, now U.S. Pat. No. 4,601,980, which is a division of application Ser. No. 06/055,126 filed July 5, 1979, now U.S. Pat. No. 4,342,832.
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| Designated Country: |
AT NL SE SU
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| Family: |
Show 175 known family members
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First Claim:
Show all 5 claims |
We claim:
1. A DNA molecule consisting of DNA encoding amino acids 1-191 of human growth hormone.
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| Background / Summary: |
Show background / summary
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| Drawing Descriptions: |
Show drawing descriptions
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| Description: |
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| Forward References: |
Show 27 U.S. patent(s) that reference this one
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| Foreign References: |
None
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| Other Abstract Info: |
CHEMABS 094(21)170974D
DERABS C81-03727D
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| Other References: |
Itakwa et al, Science, vol. 198, pp. 1056-1063, Dec. 1977.
Polisky et al, PNAS USA, vol. 73, pp. 3900-3904, Nov. 1976.
(5 pages)
Cited by 26 patents
Backman et al, Cell vol. 13, pp. 65-71, Jan. 1978.
(7 pages)
Cited by 40 patents
Seeburg et al, Nature, vol. 276, pp. 795-798, Dec. 1978.
(4 pages)
Cited by 36 patents
Villa-Komanoff et al, PNAS USA, vol. 75, pp. 3727-3731, Aug. 1978.
(5 pages)
Cited by 96 patents
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