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 Title: |
US5250295:
Natural killer cell enhancing factor
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Shau, Hungyi; Cerritos, CA
Golub, Sidney H.; Los Angeles, CA
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| Assignee: |
The Regents of the Univ. of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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| Published / Filed: |
1993-10-05
/ 1991-11-04
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| Application Number: |
US1991000787148
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| IPC Code: |
Advanced:
C07K 14/52;
A61K 38/00;
Core:
C07K 14/435;
more...
IPC-7:
A61K 37/02;
C07K 15/06;
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| U.S. Class: |
Current:
424/085.2;
424/085.1;
514/012;
514/021;
530/380;
530/402;
530/816;
530/829;
Original:
424/085.2;
424/085.1;
514/012;
514/021;
530/380;
530/402;
530/816;
530/829;
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| Field of Search: |
424/85.1,85.2,85.4
530/402,410,815,816,380,829
514/012,21
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| Government Interest: |
This invention was made with government support under Grant No. CA 3442 awarded by the National Institutes of Health. The government has certain rights in the invention.
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| Priority Number: |
| 1991-11-04 |
US1991000787148 |
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| Abstract: |
A factor (NKEF) for use in enhancing the activity of natural killer cells both in vivo and in vitro. NKEF is a soluble red blood cell cytosol protein having a molecular mass of between about 300 and 400 kilodaltons as determined by gel filtration high pressure liquid chromatography and an apparent molecular weight of about 48 kilodaltons as determined by non-reducing SDS-PAGE.
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| Attorney, Agent or Firm: |
Poms, Smith, Lande & Rose ;
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| Primary / Asst. Examiners: |
Russel, Jeffrey E.;
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| Maintenance Status: |
CC Certificate of Correction issued
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| INPADOC Legal Status: |
Show legal status actions
Family Legal Status Report
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| Designated Country: |
CA EP JP US
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| Family: |
Show 3 known family members
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First Claim:
Show all 20 claims |
What is claimed is:
1. A purified factor comprising a soluble red blood cell cytosol protein having a molecular mass of between 300 and 400 kilodaltons and an apparent molecular weight of about 48 kilodaltons as determined by non-reducing sodium dodecylsulfate polyacrylamide gel electrophoresis.
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| Background / Summary: |
Show background / summary
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| Drawing Descriptions: |
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| Description: |
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| Forward References: |
Show 3 U.S. patent(s) that reference this one
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| Foreign References: |
None
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| Other References: |
Shau, H. and Golub, S. "Modulation of Natural Killer-Mediated Lysis by Red Blood Cells", Cellular Immunology 116, 60-72, 1988.
(13 pages)
Karger, S., "Abstract from Seventh International Workshop on Natural Killer Cells", Jun. 4-7, 1991, Stockholm, Sweden.
Iho, S., Shau, H. and Golub, S., "Characteristics of Interleukin-6-Enhanced Lymphokine-Activated Killer Cell Function", Cellular Immunology 135, 66-77 (1991).
(12 pages)
[ISI abstract]
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