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 Title: |
US5322682:
Method for quantitatively measuring and mapping stored iron in tissue using MRI
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Bartzokis, George; Los Angeles, CA
Phelan, Carolanne K.; Los Angeles, CA
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| Assignee: |
The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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| Published / Filed: |
1994-06-21
/ 1992-08-06
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| Application Number: |
US1992000926245
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| IPC Code: |
Advanced:
G01R 33/465;
G01R 33/54;
Core:
G01R 33/44;
more...
IPC-7:
A61K 33/26;
G01N 24/08;
G01V 3/00;
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| ECLA Code: |
G01R33/465; G01R33/54B3;
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| U.S. Class: |
Current:
600/410;
324/300;
324/307;
324/308;
424/009.3;
424/009.34;
424/646;
436/173;
600/420;
Original:
424/009;
128/653.2;
128/653.4;
436/173;
324/300;
324/307;
324/308;
424/646;
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| Field of Search: |
424/009,646
128/653.2,653.4,654
436/173
324/300,307,308
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| Priority Number: |
| 1992-08-06 |
US1992000926245 |
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| Abstract: |
The invention provides a specific measure of iron stores in vivo using magnetic resonance imaging. T2 relaxation times in both lower-to-mid field strength magnetic resonance imaging instruments and a higher field strength instrument is evaluated. T2 obtained at the higher field strength instrument is subtracted from T2 obtained at the lower field strength instrument. This difference, T, is then correlated with a quantitative measure of the iron stores in vivo in the scanned tissue. A two-dimensional or multidimensional map of the scanned tissue is then constructed on the basis of T to visually identify different tissue types as being normal or abnormal, either through a visual determination based on gray scales or a numeric comparison based on quantitative measure. The introduction of artificial or nonbiological substances as opposed to natural ferritin, is permitted for further diagnostic use by application of this methodology.
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| Attorney, Agent or Firm: |
Dawes, Daniel L. ;
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| Primary / Asst. Examiners: |
Hollrah, Glennon H.; Hollinden, Gary E.
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| INPADOC Legal Status: |
Show legal status actions
Family Legal Status Report
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| Designated Country: |
CA EP JP
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| Family: |
Show 2 known family members
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First Claim:
Show all 27 claims |
We claim:
1. A method of specifically detecting iron stores in vivo using magnetic resonance comprising the steps of:
- measuring in vivo a parameter which is a function of T2 of at least one predetermined position within a subject at a first magnetic field strength;
- measuring in vivo a parameter which is a function of T2 at said predetermined position within said subject at a second magnetic field strength, said second magnetic field strength being unequal to said first magnetic field strength; and
- generating a field dependent T2 signal, T, by differencing T2 measured at said first and second field strengths, T being a specific indication of said iron stores in vivo.
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| Background / Summary: |
Show background / summary
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| Drawing Descriptions: |
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| Description: |
Show description
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| Forward References: |
Show 12 U.S. patent(s) that reference this one
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| Foreign References: |
None
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| Other Abstract Info: |
CHEMABS 120(15)186321E
DERABS C94-065331
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| Other References: |
Narayan, P. et al. Magn. Res. in Med. 11:209-220 (1989).
(12 pages)
Cited by 5 patents
Neurohr, K J et al. Adv. Myocardiol. 6:158-193 (1985).
Evelhoch, J L Invest. New Drugs 7:5-12 (1989).
(8 pages)
Cited by 2 patents
"Role of Iron and Ferritin in MR Imaging of the Brain: . . . ," Bizzi et al., Radiology 1990; 177:59-65.
(7 pages)
"4-tesla sites initiate clinical MR studies," by Lori D' Agincourt, Product Development pp. 81-83, 87 & 104, Diagnostic Imaging Dec. 1991.
"Magnetic Resonance Imaging and Brain Iron . . . ," Burton P. Drayer, M.D., BNI Quarterly, vol. 3 No. 4, Fall 1987, pp. 15-30.
"MRI in basal ganglia diseases," D. Wimberger et al., J. Neural Transm (1991) [suppl] 133-140 ® by Springer-Verlag 1991.
(8 pages)
[ISI abstract]
"Dashed Hopes for MR Imaging of the Head and Neck . . . ," Editorials from the Neuroradiology Section, Dept. of Radiology, Hospital of the University of Pennsylvania, Radiology 1991; 184:25-26.
"T2 -Relaxometry-A Critical Investigation . . . ," Thomas Tolxdorff et al., SMRM 1988, p. 33.
"T2 Values in the Human Brain: Comparison with Quantitative Assays of Iron and Ferritin1 " Julian C. Chen, M.D. et al. Radiology 1989, pp. 521-526.
(6 pages)
"Field Strength in Neuro-MR Imaging: A Comparison of 0.5T and 1.5T" Clifford R. Jack, Jr., et al., Journal of Computer Assisted Tomography, vol. 14, No. 4, 1990, pp. 505-513.
(9 pages)
"Nuclear Relaxation of Human Brain Gray and White Matter: Analysis of Field Dependence and Implications for MRI" Helmut W. Fisher et al., Magnetic Resonance in Medicine 16, 317-334 (1990).
"Are Hepatic and Muscle T2 Values Different at 0.5 and 1.5 Tesla?" Magnetic Resonance Imaging, vol. 7, pp. 363-367, 1989, Michael E. Bernardino et al.
(5 pages)
"Biological Significance of Iron-Related Magnetic Resonance Imaging Changes in the Brain" Arch Neurol-vol. 49, Jul. 1992, Jesus Pujol, M.D. et al.
"Transverse Relaxation of Solvent Protons Induced by Mangetized Spheres: Application to Ferritin, Erythrocytes, and Magnetite" Pierre Gillis et al. Magnetic Resonance in Medicine 5, 323-345 (1987).
(23 pages)
"MR Imaging of Intracerebral Blood: Diversity in the Temporal Pattern at 0.5 1.0T" Amer Zyed et al., AJNR 12:469-474, May/Jun. 1991;AJR 157:133-138 Jul. 1991.
(6 pages)
[ISI abstract]
"NMR Relaxation Times of Blood: Dependence on Field Strength, Oxidation State, and Cell Integrity" John M. Gomori et al., J Comput Assit Tomogr, vol. 11, No. 4 1987, pp. 684-690.
(7 pages)
Cited by 3 patents
"Does signal-attenuation on high-field T2 -weighted MRI of the brain reflect regional cerebral iron deposition? Observations on the relationship between regional cerebral water proton T2 values and iron levels" D. J. Brooks et al., Journal of Neurology, Neurosurgery, and Psychiatry 1989; 52:108-111.
(4 pages)
"Notes On the Origin of Paramagnetic Inhomogeneity Effects in Whole Blood" N. A. Watwiyoff et al., Magnetic Resonance in Medicine 20, 144-150 (1991).
"T2 Estimates in Healthy and Diseased Brain Tissue: A Comparison Using Various MR Pulse Sequences1 " Robert H. Darwin et al., Radiology 1986;160:375-381.
(7 pages)
"Reproducibility of Relaxation and Spin-Density Parameters in Phantoms and the Human Brain Measured by MR Imaging at 1.5T" Robert K. Breger et al., Magnetic Resonance in Medicine 3, 649-662 (1986).
(14 pages)
"In-vivo Measurements of MRI Tissue Parameters at Various Magnetic Field Strengths" By Jyh-Horng Chen, Dissertation, Univ. of Calif. Berkeley with San Francisco (1991).
"MR Imaging of Cerebral Hematomas at Different Field Strengths: Theory and Applications" Rodney A. Brooks et al., J. Cpmput Assist Tomogr vol. 13 No. 2 1989 pp. 194-206.
(13 pages)
"Hepatic Iron Overload: Quantitive MR Imaging1 " John M. Gomori et al., Radiology 1991;179;367-369.
(3 pages)
[ISI abstract]
"The Role of Ferritin and Hemosiderin in the MR Appearance of Cerebral Hemorrhage: A Histopathologic Biochemical Study in Rats" Keith R. Thulborn et al., AJNR 11:291-297, Mar./Apr. 1990; AJR 154:May 1990.
(7 pages)
"Diffusion-Weighted MR Imaging of Acute Stroke: Correlation with T2 -Weighted and Magnetic Susceptibility-Enhanced MR Imaging in Cats" M. E. Moseley et al., AJNR 11:423-429, May/Jun. 1990.
(7 pages)
Cited by 4 patents
"Late Onset Familial Hallervorden-Spatz Disease: MR Findings in Two Sisters" Paolo Ambrosetto, et al., AJNR 13:394-396, Jan/Feb 1992 1095-6108/92/1301-0394 ©American Society of Neuroradiology.
(3 pages)
[ISI abstract]
"MR Imaging of Parkinson Disease with Spin-Echo and Gradient-Echo Sequences" Bruce H. Braffman1.2, AJR 152:159-165, Jan. 1989.
(7 pages)
"Brain Iron in Patients with Parkinson Disease: MR Visualization Using Gradient Modification" Joseph F. Norfray1 et al., AJNR 9:237-240, Mar./Apr. 1988.
(4 pages)
"Study of Movement Disorders and Brain Iron by MR" J. Neal Rutledge1.2 et al., AJNR 8:397-411, May/Jun. 1987.
(15 pages)
"Magnetic Resonance Imaging in Huntington Disease" J. Thayer Simmons et al., AJNR 7:25-28, Jan./Feb. 1986.
(4 pages)
"Mechanisms of MR Signal Alteration by Acute Intracerebral Blood: Old Concepts New Theories" L. Anne Hayman et al., AJNR 12:899-907, Sep./Oct. 1991.
(9 pages)
[ISI abstract]
"Detection of Acute Intracerebral Hemorrhage on MR Imaging: Ineffectiveness of Prolonged Interecho Interval Pulse Sequences" Weingarten et al., AJNR 12:475-479, May/Jun. 1991.
(5 pages)
[ISI abstract]
"Clinically Documented Hemorrhage in Cerebral Arteriovenous Malfunctions: MR Characteristics" Phylliss M. Chappell et al., Radiology 1992; 183:719-724.
(6 pages)
[ISI abstract]
"Parkinson Plus Syndrome: Diagnosis Using High Field MR Imaging of Brain Iron" Burton P. Drayer et al., Radiology 1986; 159:493-498.
(6 pages)
"Imaging of the Aging Brain Part II. Pathologic Conditions1 " Burton P. Drayer, MD, Radiology 1988; 166:797-806.
(10 pages)
"Imaging of the Aging Brain Part I. Normal Findings1 " Burton P. Drayer, MD, Radiology 1988; 166:785-796.
(12 pages)
"Wilson Disease of the Brain: MR Imaging1 " Alex M. Aisen et al., Radiology 1985; 157:137-141.
(5 pages)
"Multiple System Atrophy (Shy-Drager Syndrome): MR Imaging1 " Behram Pastakia et al., Radiology 1986; 159:499-502.
(4 pages)
¢Mangetic Resonance Imaging of Transfusional Hemosiderosis Complicating Thalassemia Major1 " Robert C. Brasch et al., Radiology 1984; 150:767-771.
(5 pages)
"Intracranial Hematomas: Imaging by High-Field MR1 " John M. Comori, et al., Radiology 1985; 157:87-93.
"Magnetic Resonance Imaging of the Midbrain in Parkinson's Disease" J. R. Duguid et al., Annals of Neurology vol. 20 No. 6 Dec. 1986, pp. 744-747.
(4 pages)
"Nuclear Magnetic Resonance Imaging in Movement Disorders" Steven A. Lukes, et al, Annals of Neurology vol. 13 No. 6 Jun. 1983 pp. 690-691.
(2 pages)
"High-Field MR Imaging of Superficial Siderosis of the Central Nervous System" John M. Gomori et al., J Comput Assist Tomogr vol. 9 No. 5 1985 pp. 972-975.
(4 pages)
"Brain Iron in Progressive Supranuclear Palsy: Clinical, Magnetic Resonance Imaging . . . " C. Edward Coffey et al., Journal of Neuropsychiatry vol. 1 No. 4 Fall 1989.
"MRI in autonomic failure" Robert T. Brown et al., Journal of Neurology, Neurosurgery and Psychiatry 1987; 50:913-914.
(2 pages)
"Magnetic Resonance Imaging of Dystonic States" J. Neal Rutledge et al., Advances in Neurology, vol. 50 pp. 265-275 (1988).
"MRI of Brain Iron" Burton Drayer1.2 " et al., ARJ 147:103-110 Jul. 1986.
(8 pages)
"Assessment of Tissue Iron Overload by Nuclear Magnetic Resonance Imaging" Johnston et al., American Journal of Medicine vol. 87 Jul. 1989 pp. 40-47.
(8 pages)
"Nuclear Magnetic Resonance of Iron and Copper Disease States" Val M. Runge et al., ARJ 141:943-948, Nov. 1983.
(6 pages)
"Early Detection of Regional Cerebral Ischemia in Cats: Comparison of Difusion- and T2-Weighted MRI and Spectroscopy" M. E. Moseley et al., Magnetic Resonance in Medicine 14, 330-346 (1990).
(17 pages)
Cited by 6 patents
"Lesions of the putamen: Their relevance to dystonia" R. D. Fross et al., Neurology 1987; 37:1125-1129.
(5 pages)
"MR Imaging of Cerebral Hematomas at Different Field Strengths: Theory and Applications" Rodney A. Brooks et al., J Comput Assist Tomogr 13(2):194-206 1989.
(13 pages)
"Magnetic resonance imaging of stationary blood: A review" Rodney A. Brooks et al., Med. Phys. 14(6), Nov./Dec. 1987 pp. 903-913.
(11 pages)
Cited by 2 patents
"Striatonigral degeneration: Clinical, MRI, and pathologic correlation" Christopher O'Brien et al., Neurology 1990; 40:710-711 (1990).
(2 pages)
"Magnetic resonance imaging in pathologically proven Hallervorden-Spatz disease" Schaffert et al., Neurology 39 Mar. 1989 pp. 440-442.
(3 pages)
"NMR Imaging of the Liver in Two Cases of Iron Overload" Leung et al., J Comput Asst Tomogr 8(3):446-449 Jun. 1984.
(4 pages)
"Magnetic Resonance Imaging and Spectroscopy of Hepatic Iron Overload" Stark et al., Radiology 1985; 154: 137-142.
(6 pages)
"Low Paramagnetic-Ion Content in Cancer Cells: Its Significance in Cancer Detection by Magnetic Resonance Imaging" Ling et al., Physiol. Chem. Phys. & Med. NMR (1990)22:1-14.
(14 pages)
"Parenchymal versus Reticuloendothelial Iron Overload in the Liver: Distinction with MR Imaging" Siegelman et al., Radiology 1991; 179:361-366.
(6 pages)
[ISI abstract]
"The Effects of Iron Oxides on Proton Relaxivity" Josephson et al., Magnetic Resonance Imaging vol. 6 pp. 647-653, 1988.
(7 pages)
Cited by 2 patents
"Quantitation of MR Relaxation Effects of Iron Oxide Particles in Liver and Spleen" Majumdar et al., Radiology 1988; 169:653-655.
(3 pages)
"Bone Marrow Imaging Using Stir at 0.5 and 1.5T" Kendall M. Jones et al., Magnetic Resonance Imaging vol. 10 pp. 169-176 1992.
(8 pages)
[ISI abstract]
"Transverse Relaxation (1/T2) of Solvent Protons Induced by Magnetized Spheres and Its Relevance to Contrast Enhancement in MRI" Koenig et al., Investigative Radiology vol. 23 9-88 pp. S224-S228 (1988).
(5 pages)
"Structure Activity Relationship of Magnetic Particles as MR Contrast Agents" Thomassen et al., Magnetic Resonance Imaging vol. 9 pp. 255-258. (1991).
(4 pages)
Cited by 3 patents
[ISI abstract]
"Cardiovascular MR Imaging with Iron Oxide Particles: Utility of A superparamagnetic Contrast Agent and the Role of Diffusion in Signal Loss" Rozenmann et al., Radiology 1990; 175:655-659.
(5 pages)
"Ferrite Particles: A superparamagnetic MR Contrast AGent for Enhanced Detection of Liver Carcinoma" Sanjay Saini et al., Radiology 1987; 162:217-222.
(6 pages)
Cited by 7 patents
"MR Imaging of Splenic Matastases: Ferrite-Enhanced Detection in Rats" Reissleder et al., AJR 149:723-726, Oct. 1987.
"MR Receptor Imaging: Ultrasmall Iron Oxide Particles Targeted to Asialoglycoprotein Receptors" Ralph Weissleder et al., AJR 155:1161-1167 Dec. 1990.
(7 pages)
Cited by 6 patents
"Hepatic Cirrhosis and Hepatitis: MR Imaging Enhanced with Superaramagnetic Iron Oxide" Guillermo Elizondo et al., Radiology 1990; 174:797-801.
(5 pages)
"Hepatic Micrometastases in the Rat: Ferrite-enhanced MR Imaging" Yuk-Ming Tsang et al., Radiology 1988; 167:21-24.
(4 pages)
Cited by 6 patents
"Superparamagnetic Iron Oxide-enhanced MR Imaging: Pulse Sequence Optimization for Detection of Liver Cancer" Fretz et al., Radiology 1989; 172:393-397.
(5 pages)
"Magnetoferritin: In Vitro Synthesis of a Novel Magnetic Protein" Fiona C. Meldrum et al., Science vol. 257 Jul. 24, 1992 pp. 522-523.
(2 pages)
Cited by 8 patents
[ISI abstract]
"Iron Oxide-Enhanced MR Imaging of the Liver and Spleen: Review of the First 5 Years" Ferrucci et al., AJR 155:943-950 Nov. 1990.
(8 pages)
"Non-invasive quantitation of liver iron-overload by magnetic resonance imaging" Kaltwasser et al., British Journal of Haematology 1990 74 360-363.
(4 pages)
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