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Title: US5348945: Method of treatment with hsp70
[ Derwent Title ]


Country: US United States of America

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9 pages

 
Inventor: Berberian, Paul A.; Winston-Salem, NC
Tytell, Michael; Winston-Salem, NC
Gower, David J.; Oklahoma City, OK

Assignee: Wake Forest University, Winston-Salem, NC
other patents from WAKE FOREST UNIVERSITY (616825) (approx. 75)
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Published / Filed: 1994-09-20 / 1993-06-11

Application Number: US1993000076279

IPC Code: Advanced: A61K 38/16;
Core: more...
IPC-7: A61K 37/02;

ECLA Code: A61K38/16;

U.S. Class: Current: 514/021; 514/012;
Original: 514/021; 514/012;

Field of Search: 514/012,21

Priority Number:
1993-06-11  US1993000076279
1990-04-06  US1990000505934
1991-04-04  US1991000680209

Abstract: A method of combating mortality in a cell or tissue under stress is disclosed. The method comprises contacting hsp70 to the cell or tissue in an amount effective to enhance the survival of that cell or tissue. The method may be employed in the combating of atherosclerosis, restenosis after angioplasty, and nerve damage in human or animal subjects in need of such treatment. A pharmaceutical composition comprising a therapeutically effective amount of hsp70 in a pharmaceutically acceptable formulation is also disclosed.

Attorney, Agent or Firm: Bell Seltzer Park & Gibson ;

Primary / Asst. Examiners: Wityshyn, Michael G.; Koh, Choon P.

INPADOC Legal Status: None          Buy Now: Family Legal Status Report

       
Related Applications:
Application Number Filed Patent Pub. Date  Title
US1991000680209 1991-04-04       
US1990000505934 1990-04-06       


       
Parent Case:     This application is a continuation of application Ser. No. 07/680,209, filed 4, Apr. 1991, now abandoned, which is a continuation-in-part of-co-pending application Ser. No. 07/505,934, filed Apr. 6, 1990, now abandoned.

Designated Country: AT BE CH DE DK ES FR GB GR IT LI LU NL SE  AU CA EP JP 

Family: Show 7 known family members

First Claim:
Show all 32 claims
That which is claimed is:     1. A method of combatting mortality in a tissue under stress, which stress induces an endogenous HSP70 response in said tissue, said method comprising contacting exogenous HSP70 to the tissue in an amount effective to enhance the survival of cells in that tissue.

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Forward References: Show 73 U.S. patent(s) that reference this one

       
U.S. References: Go to Result Set: All U.S. references   |  Forward references (73)   |   Backward references (0)   |   Citation Link

       
Foreign References:
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PDF
Publication Date IPC Code Assignee   Title
Buy PDF- 43pp WO8912455 1989-09  A61K 37/02 MEDICAL RES COUNCIL STRESS PROTEINS AND USES THEREFOR 
Buy PDF- 87pp WO9002564 1990-03  A61K 39/00 CODON VACCINE DIAGNOSTIC EMPLOYING PROTEINS HOMOLOGOUS TO HEAT SHOCK PROTEINS OF TRYPANOSOMA CRUZI 


Other Abstract Info: CHEMABS 115(23)248133C DERC94-302228 DERABS C91-324950 DERABS C94-302228

Other References:
  • Tytell et al, Adv. in Neurology, vol. 59, edited by Frederick J. Seil, Raven Press, Ltd., NY 1993, pp. 293-303.
  • Tytell et al, Transactions of the Amer. Soc. for Neurochem. (1994) Abstract.
  • Smith et al, Biological Bulletin, vol. 185: 293-294 (1993). (2 pages) [ISI abstract]
  • Johnson et al, Experimental & Molecular Pathology, 58: 155-168 (1993). (14 pages) Cited by 2 patents [ISI abstract]
  • Widnell et al, Essenhal Cell Biology, (1990) pp. 116-130.
  • P. Berberian, Ph.D., Stress Protein in Plaque: Troublemaker or Troubleshooter?, American Heart Association's Sixteenth Science Writers Forum, Monterey, Calif., Jan. 15-18, 1989.
  • M. Barbe et al., "Hyperthermia Protects Against Light Damage in the Rat Retina," Science 241, 1817 (1988). (4 pages)
  • P. Berberian et al., "Exogenous 70 Kd Heat Shock Protein Increases Survival of Arterial Cells from Normal and Atherosclerotic Aortas," Arteriosclerosis 9, No. 5, 726a (1989). (1 pages)
  • P. Berberian et al., "Update: Heat Shock Protein and Arterial Cell Death," The Stroke Monitor, p. 1 (Spring 1989).
  • H. Chiang et al., "A Role for a 70-Kilodalton Heat Shock Protein in Lysosomal Degradation of Intracellular Proteins," Science 246, 382 (1989). (4 pages) Cited by 2 patents
  • M. Chopp et al., "Heat Shock and Thermotolerance in Early Rat Embryo Development," Neurology 39, 1396 (1989).
  • M. Chopp et al., "Reduction of Hyperthermic Ischemic Acidosis by a Conditioning Event in Cats," Stroke 20, No. 10, 1357-1360 (Oct. 1989). (4 pages)
  • L. Hightower and P. Guidon, "Selective Release from Cultured Mammalian Cells of Heat-Shock Proteins," J. Cell. Physiol. 138, 257 (1989). (10 pages) Cited by 4 patents
  • H. Pelham, "Heat Shock and the Sorting of Luminal ER Proteins," EMBO Journal 8, No. 11, 3171 (1989). (6 pages) Cited by 5 patents
  • S. Tomosovic and D. Welsh, "Heat Stress Proteins and Experimental Cancer Metastasis," Int. J. Hyperthermia 2, No. 3, 253 (1986).
  • D. Walsh et al., "Heat Shock and Thermotolerance During Early Rat Embryo Development," Teratology 36, 181-191 (1987). (11 pages)
  • D. Walsh et al., "Regulation of the Inducible Heat Shock 71 Genes in Early Neural Development of Cultured Rat Embryos," Teratology 40, 321-334 (1989). (14 pages)
  • R. Allen et al., "A Novel hsp70-Like Protein (P70) is Present in Mouse Spermatogenic Cells," Mol. Cell. Biol. 8, 828 (1988). (5 pages) Cited by 2 patents
  • P. Berberian et al., "Exogenous 70 Kd Heat Shock Protein Increases Survival of Normal and Atheromatous Arterial Cells," FASEB J. 4, A1031 (1990).
  • V. Guerriero et al., "HSP70-Related Proteins in Bovine Skeletal Muscle," J. Cell. Physiol. 140, 471 (1989). (7 pages)
  • T. Hatayama et al., "Separation of Rat Liver HSP70 & HSP71 by High Performance Liquid Chromatography with a Hydroxylapatite Column," J. Chromatog. 481, 403 (1989). (8 pages)
  • A. Johnson et al., "Time-Correlated Cytoprotection by 70kD Heat Shock Protein in Arterial Cells During Metabolic Stress," FASEB J. 4, A1032 (1990).
  • A. Johnson et al., "Effect of Heat Shock Proteins on Survival of Isolated Aortic Cells from Normal and Atherosclerotic Cynomolgus Macaques," Atherosclerosis 84, 111 (1990). (9 pages) Cited by 2 patents
  • D. Macejak et al., "Isolation and Characterization of Human HSP70 Expressed in Escherichia coli," Arch. Biochem. Biophys. 280, 53 (1990). (8 pages)
  • N. Mivechi et al., "Effects of Heat Shock Proteins (Mr 70,000) on Protein and DNA Synthesis at Elevated Temperatures in vitro," Cancer Res. 49, 1492 (1989). (5 pages)


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