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Title: US5387508: Detection of cytotoxic agents using tetramitus rostratus
[ Derwent Title ]

Country: US United States of America

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17 pages

 
Inventor: Jaffe, Robert L.; Long Island City, NY

Assignee: None

Published / Filed: 1995-02-07 / 1992-05-14

Application Number: US1992000883257
IPC Code: Advanced: C12Q 1/18;
Core: more...
IPC-7: C12N 1/00; C12N 1/10; C12Q 1/00; C12Q 1/02;

ECLA Code: C12Q1/18;

U.S. Class: Current: 435/032; 435/004; 435/029; 435/258.1; 435/947;
Original: 435/032; 435/004; 435/029; 435/258.1; 435/947;

Field of Search: 435/029,947,258,32,4

Priority Number:
1992-05-14  US1992000883257

Abstract: Cytotoxic agents, and particularly DNA-damaging agents, can be detected in a sample by a method comprising the steps of
  • (a) adding the sample to a living culture of Tetramitus rostratus in flagellate form,
  • (b) determining the growth rate of the T. rostratus culture in the presence of the sample, and
  • (c) comparing the growth rate of the T. rostratus culture in the presence of the sample to a standard growth rate. A decrease in growth rate is indicative of the presence of cytotoxic agents in the sample. The use of the flagellate T. rostratus allows this assay to be used on solid as well as liquid or gaseous samples because T. rostratus ingests particulate materials via a gullet.


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Attorney, Agent or Firm: Oppedahl & Larson ;

Primary / Asst. Examiners: Wityshyn, Michael G.; Williams, Jane
Family: None
First Claim:
Show all 17 claims		 I claim:     1. A method for the detection of cytotoxic agents in a sample comprising the steps of:
  • (a) adding the sample to a living culture of Tetramitus rostratus in flagellate form;
  • (b) determining the growth rate of the flagellate Tetramitus rostratus culture in the presence of the sample; and
  • (c) comparing the growth rate of the flagellate Tetramitus rostratus culture in the presence of the sample to a standard growth rate, wherein a decrease in growth rate of the culture in the presence of the sample is indicative of the presence of cytotoxic agents in the sample.
    •


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Forward References: Show 5 U.S. patent(s) that reference this one

       
U.S. References: Go to Result Set: All U.S. references   |  Forward references (5)   |   Backward references (0)   |   Citation Link

       
Foreign References: None

Other Abstract Info: CHEMABS 122(15)180888Q CAN122(15)180888Q DERABS C95-089270 DERC95-089270

Other References:
  • De Flora et al., "Genotoxic Activity and Potency of 135 Compounds in the Ames Reversion Test and in a Bacterial DNA-repair Test", Mut. Research, 133:161-198 (1984).
  • Ashby et al., "Classification According to Chemical Structure, Mutagenicity to Salmonella and Level of Carcinogenicity of a Further 42 Chemicals Tested for Carcinogencity by the U.S. National Toxicology Program", Mut. Research, 223:73-103 (1989). (31 pages)
  • Whong et al., "Development of an In Situ Microbial Mutagenicity Test System for Airborne Workplace Mutagens: Laboratory Evaluation", Mut. Research, 130:45-51 (1984). (7 pages) Cited by 2 patents
  • Ashby et al., "Chemical Structure, Salmonella Mutagenicity and Extent of Carcinogenicity as Indicators of Genotoxic Carcinogenesis among 222 Chemicals tested in Rodents by the U.S. NCI/NTP", Mut. Research, 204:17-115 (1988). (99 pages) Cited by 2 patents
  • Hillebrandt, et al., Radiat. Environ. Biophys (1991) (vol. 30) 123--130. (8 pages) Cited by 2 patents [ISI abstract]
  • Fulton, Science (vol. 167) pp. 1269-1270 (1970).
  • Whong, et al., Mutation Research (vol. 130) (1984) pp. (45-51). (7 pages) Cited by 2 patents
  • Kamp, et al., J. Lab Clin Med. pp. 604-612 (vol. 114, No. 5), pp. 604-612 (1989). (9 pages)
  • Jaffe, et al., Cancer Letters (vol. 20) pp. 37-42 (1983). (6 pages)
  • Phillips, D., Environmental Pollution (vol. 13) (1977) (pp. 281-317). (37 pages) Cited by 5 patents
  • Duez, P., et al., J of Ethnopharmacology (vol. 34) (1991) pp. 235246.


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