Viruses expressing chimeric binding proteins (US5403484)


	Parent Case:			This is a division of parent application Ser. No. 07/664,989, filed Mar. 1, 1991, now U.S. Pat. No. 5,223,409, which is a CIP of U.S. Ser. No. 07/487,063, filed Mar. 2, 1990, now abandoned which is a CIP of 07/240,160, filed Sep. 2, 1988, now abandoned.
	Designated Country:			BB BG BR CS HU KP KR LK MG MN MW OA PL RO SD SU BE CH DK FR GB GR IT LI LU MC NL SE FI NO
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	First Claim: Show all 49 claims			We claim: 1. A virus bearing on its outer surface a chimeric binding protein, said protein comprising (i) a proteinaceous binding domain, other than a single chain antibody, which is sufficiently stable in structure to have a melting point of at least 40° C., and which binds to a target:, other than the variable domain of an antibody, sufficiently strongly so that the dissociation constant of the binding domain: target complex is less than 10^-6 moles/liter, and (ii) at least a functional portion of a coat protein of said virus, said portion acting, when the chimeric protein is produced in a suitable host cell, to cause the display of the chimeric binding protein or a processed form thereof on the outer surface of the virus, said binding domain being capable of binding to a target material which said coat protein does not preferentially bind, said binding domain being foreign to the native coat proteins of said virus.
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	Forward References:			Show 233 U.S. patent(s) that reference this one

U.S. References:

Go to Result Set: All U.S. references | Forward references (233) | Backward references (22) | Citation Link

Patent	Pub.Date	Inventor	Assignee	Title
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US4332897	1982-06	Nakano et al.	Noda Institute for Scientific Research	Novel bacteriophage and method for preparing same
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US4348477	1982-09	Nakano et al.	Noda Institute for Scientific Research	Method for preparing a recombinant DNA phage
US4348478	1982-09	Nakano et al.	Noda Institute for Scientific Research	Method for preparation of a recombinant DNA phage
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US4595674	1986-06	Tschesche et al.	Bayer Aktiengesellschaft	Homologues of aprotinin with, in place of lysine, other aminoacids in position 15, process for their preparation and their use as medicaments
US4642334	1987-04	Moore et al.	DNAX Research Institute of Molecular and Cellular Biology, Inc.	Hybrid DNA prepared binding composition
US4703004	1987-10	Hopp et al.	Immunex Corporation	Synthesis of protein with an identification peptide
US4704692	1987-11	Ladner		Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides
US4757013	1988-07	Inouye et al.	The Research Foundation of State University of New York	Cloning vehicles for polypeptide expression in microbial hosts
US4769326	1988-09	Rutter	The Regents of the University of California	Expression linkers
US4769327	1988-09	Stephens et al.	Biotechnica International, Inc.	Secretion vector
US4774180	1988-09	Toth et al.	Massachusetts Institute of Technology	Construction and application of polyproteins
US4797363	1989-01	Teodorescu et al.	Board of Trustees, University of Illinois	Bacteriophages as recognition and identification agents
US4829052	1989-05	Glover et al.	Monsanto Company	Serine protease inhibitors
US4894436	1990-01	Auerswald et al.	Bayer Aktiengesellschaft	Homologs of aprotinin produced from a recombinant host, process expression vector and recombinant host therefor and pharaceutical use thereof
US4908773	1990-03	Pantoliano et al.	Genex Corporation	Computer designed stabilized proteins and method for producing same
US5010175	1991-04	Rutter et al.	The Regents of the University of California	General method for producing and selecting peptides with specific properties

Foreign References:

Publication	Date	IPC Code	Assignee	Title
EP0286239	1988-06	C12N 15/00	NEW ENGLAND BIOLABS INC	Production and purification of a protein fused to a binding protein
EP0297362	1988-06	C07K 7/10	BAYER AG	Human aprotinine whose Lys residue in position 15 is substituted by another protogene redisue of amino-acid
EP0285123	1988-11	C12N 9/26	Cultor Ltd.	A method for complete mutagenesis of nucleic acids
EP0339942	1989-11	A61K 38/00	NOVO-NORDISK A/S	Aprotinin analogues and process for the production thereof
EP0341444	1989-11	G01N 33/53	GEN HOSPITAL CORP	Rapid mutational analysis method
GB2188322	1987-09	A61K 38/00	* BAYER AKTIENGESELLSCHAFT	APROTININ AND ANALOGUES THEREOF PRODUCED BY A RECOMBINANT HOST
GB2188933	1987-10	A61K 38/00	* BAYER AKTIENGESELLSCHAFT	EXPRESSION VECTORS FOR PRODUCTION OR POLYPEPTIDES, METHOD FOR EXHANCED EXPRESSION OF POLYPEPTIDES, HOSTS CONTAINING THE EXPRESSION VECTORS, PRODUCTS MANUFACTURED THEREBY
GB2208511	1989-04	A61K 38/00	* BAYER AKTIENGESELLSCHAFT	VARIANTS OF BOVINE PANCREATIC TRYPSIN INHIBITOR PRODUCED BY RECOMBINANT DNA TECHNOLOGY
WO8701374	1987-03	A61K 38/00	PIECZENIK GEORGE	METHOD AND MEANS FOR SORTING AND IDENTIFYING BIOLOGICAL INFORMATION
WO8806630	1988-06	C07K 16/00	GENEX CORPORATION	METHOD FOR THE PREPARATION OF BINDING MOLECULES
WO8806601	1988-09	A61K 38/00	GENEX CORPORATION	GENE REPRESSORS
WO8801649	1988-10	A61K 38/00	GENEX CORPORATION	SINGLE POLYPEPTIDE CHAIN BINDING MOLECULES
WO8901968	1989-03	C12N 9/99	BJORN, Soren, Erik	APROTININ HOMOLOGUES AND PROCESS FOR THE PRODUCTION OF APROTININ AND APROTININ HOMOLOGUES IN YEAST
WO9002809	1990-03	C12N 15/00	PROTEIN ENG CORP	GENERATION AND SELECTION OF RECOMBINANT VARIED BINDING PROTEINS
WO9117271	1991-11	C07K 14/00	AFFYMAX TECH NV	RECOMBINANT LIBRARY SCREENING METHODS
WO9118980	1991-12	C07K 14/00	CETUS CORP	COMPOSITIONS AND METHODS FOR IDENTIFYING BIOLOGICALLY ACTIVE MOLECULES
WO9119818	1991-12	C12N 1/21	AFFYMAX TECH NV	PEPTIDE LIBRARY AND SCREENING SYSTEMS
WO9118980	1991-12	C07K 14/00	CETUS CORP	COMPOSITIONS AND METHODS FOR IDENTIFYING BIOLOGICALLY ACTIVE MOLECULES
WO9206176	1992-04	C12N 1/21	IXSYS INC	SURFACE EXPRESSION LIBRARIES OF RANDOMIZED PEPTIDES
WO9206204	1992-04	C07K 14/00	IXSYS, INC.	SURFACE EXPRESSION LIBRARIES OF HETEROMERIC RECEPTORS
WO9211272	1992-07	C07H 15/12	IXSYS, INC.	OPTIMIZATION OF BINDING PROTEINS