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Title: US5405749: Method for identifying and purifying a cancer associated retinopathy autoantigen, and testing patient serum for the autoantibody to the autoantigen
[ Derwent Title ]


Country: US United States of America

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12 pages

 
Inventor: Polans, Arthur S.; Portland, OR 97214
Palczewski, Krzysztof; Beaverton, OR 97005

Assignee: None

Published / Filed: 1995-04-11 / 1991-12-06

Application Number: US1991000804894

IPC Code: Advanced: C07K 14/47; G01N 33/538; G01N 33/564; G01N 33/574;
Core: C07K 14/435; G01N 33/536; more...
IPC-7: C07K 3/00; C07K 13/00; G01N 33/574;

ECLA Code: C07K14/705; G01N33/538; G01N33/564; G01N33/574;

U.S. Class: Current: 435/007.23; 435/007.2; 435/007.21; 435/007.92; 436/063; 436/064; 436/506; 436/813; 530/350; 530/413; 530/416; 530/417;
Original: 435/007.23; 435/007.2; 435/007.21; 435/007.92; 436/506; 436/813; 436/063; 436/064; 530/350; 530/413; 530/416; 530/417;

Field of Search: 435/7.23,7.2,7.21,7.92 436/506,813,63,64,541 530/350,403,413,416,417

Priority Number:
1991-12-06  US1991000804894

Abstract: A method of screening for cancer-associated retinopathy including the steps of acquiring a purified aliquot of 26 kDa protein, and, utilizing this protein, or peptides derived therefrom, performing a patient-serum assay to identify in a sample of a patient's serum the presence of autoantibodies to the 26 kDa protein autoantigen.

Attorney, Agent or Firm: Kolisch, Hartwell, Dickinson, McCormack & Heuser ;

Primary / Asst. Examiners: Scheiner, Toni R.;

Maintenance Status: E3 Expired  Check current status

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First Claim:
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It is desired to claim and secure by Letters Patent:     1. A method for detecting autoantibodies indicative of cancer-associated retinopathy, wherein the method comprises
  • (a) acquiring a selected retina source, and purifying therefrom an aliquot of a purified and isolated protein according to SEQ ID NO:1, wherein the step of purifying includes a two-step chromatographic procedure,
  • (b) performing an immunoassay by contacting a patient's serum with the isolated protein of step (a) and detecting in the patient's serum the presence of autoantibodies which specifically bind the isolated protein,
  • wherein the presence of autoantibodies which specifically bind the isolated protein is indicative of cancer-associated retinopathy.


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Forward References: Show 6 U.S. patent(s) that reference this one

       
U.S. References: Go to Result Set: All U.S. references   |  Forward references (6)   |   Backward references (0)   |   Citation Link

       
Foreign References: None

Other Abstract Info: CHEMABS 123(07)079019C CAN123(07)079019C DERABS C95-160500 DERC95-160500

Other References:
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