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Title: US5424199: Human growth hormone
[ Derwent Title ]
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Country: US United States of America

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17 pages

 
Inventor: Goeddel, David V.; Burlingame, CA
Heyneker, Herbert L.; Burlingame, CA

Assignee: Genentech, Inc., South San Francisco, CA
other patents from GENENTECH, INC. (218000) (approx. 2,164)
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Published / Filed: 1995-06-13 / 1994-05-27

Application Number: US1994000250639
IPC Code: Advanced: A61K 38/27; C07G 99/00; C07H 21/00; C07H 21/04; C07K 14/00; C07K 14/575; C07K 14/61; C12N 1/20; C12N 1/21; C12N 15/00; C12N 15/09; C12N 15/10; C12N 15/18; C12N 15/62; C12N 15/63; C12N 15/64; C12N 15/66; C12N 15/70; C12N 15/72; C12P 19/34; C12P 21/00; C12P 21/02; C12R 1/125; C12R 1/19; C12R 1/42; C12R 1/46;
Subclass: C12N;
C12P;
IPC-7:
C12P 21/02;
G12N 15/70;

ECLA Code: C12N15/66; C07K14/61; C12N15/10; C12N15/62; C12N15/70; M07K319/00; M07K319/02; M07K319/50; M07K319/75;

U.S. Class: Current: 435/069.4; 435/068.1; 435/069.1; 435/069.7; 435/091.1; 435/091.4; 435/091.42; 435/091.5; 435/320.1;
Original: 435/069.4; 435/069.1; 435/069.7; 435/320.1; 435/091.1; 435/091.4; 435/091.42; 435/091.5; 435/172.3; 935/009; 935/013; 935/029; 935/056; 935/038; 935/060; 935/073;

Field of Search: 435/320.1,91.1,91.4,91.42,91.5,172.3,69.1,69.4,69.7 530/399,412 536/23.51 935/009,13,29,38,39,40,56,60,73,12

Priority Number:
1994-05-27  US1994000250639
1993-04-26  US1993000053839
1992-03-26  US1992000859285
1989-08-14  US1989000393808
1987-04-13  US1987000037319
1984-09-25  US1984000654340
1982-03-09  US1982000356564
1979-07-05  US1979000055126

Abstract:     Described are methods and means for the construction and microbial expression of quasi-synthetic genes arising from the combination of organic synthesis and enzymatic reverse transcription from messenger RNA sequences incomplete from the standpoint of the desired protein product. Preferred products of expression lack bio-inactivating leader sequences common in eukaryotic expression products but problematic with regard to microbial cleavage to yield bioactive material. Illustrative is a preferred embodiment in which a gene coding for human growth hormone (useful in, e.g., treatment of hypopituitary dwarfism) is constructed and expressed.

Primary / Asst. Examiners: Low, Christopher S. F.;

Maintenance Status: E3 Expired  Check current status
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Related Applications: Go to Result Set: 1 patent(s) that list this one as related
Application Number Filed Patent Pub. Date  Title
US1993000053839 1993-04-26       
US1992000859285 1992-03-26       
US1989000393808 1989-08-14       
US1987000037319 1987-04-13    1990-02-06  Human growth hormone DNA
US1984000654340 1984-09-25    1987-04-14  Methionyl human growth hormone
US1982000356564 1982-03-09    1986-07-22  Microbial expression of a gene for human growth hormone
US1979000055126 1979-07-05    1982-08-03  Method of constructing a replicable cloning vehicle having quasi-synthetic genes


       
Parent Case:     This is a continuation of application Ser. No. 08/053,839, filed Apr. 26, 1993, now abandoned, which is a continuation of application Ser. No. 07/859,285 filed Mar. 26, 1992, now abanoned, which is a continuation of application Ser. No. 07/393,808 filed Aug. 14, 1989, now abandoned, which is a continuation of application Ser. No. 07/037,319 filed Apr. 13, 1987, now U.S. Pat. No. 4,898,830, which is a continuation of Ser. No. 06,654,340 filed Sep. 25, 1984, now U.S. Pat. No. 4,658,021, which is a divisional of application Ser. No. 06/356,564 filed Mar. 9, 1982, now U.S. Pat. No. 4,601,980, which is a divisional of application Ser. No. 06/055,124 filed Jul. 5, 1979, now U.S. Pat. No. 4,342,832.

Designated Country: NL SE  SU 

Family: Show 175 known family members
Claim We claim:     1. A method of producing a protein consisting essentially of amino acids 1-191 of human growth hormone comprising:
  • (a) expressing in a transformant bacterium, DNA coding for a human growth hormone conjugate protein, which conjugate protein consists essentially of amino acids 1-191 of human growth hormone as set forth in confined FIGS. 1 and 3 unaccompanied by the leader sequence of human growth hormone or other extraneous protein bound thereto and an additional amino acid sequence which is specifically cleaveable by enzymatic action, and
  • (b) cleaving extracellularly sid conjugate protein by enzymatic action to produce said protein consisting essentially of amino acids 1-191 of human growth hormone.
    •


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Forward References: Show 23 U.S. patent(s) that reference this one

       
U.S. References: Go to Result Set: All U.S. references   |  Forward references (23)   |   Backward references (17)   |   Citation Link

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PDF		 Patent  Pub.Date  Inventor Assignee   Title
Get PDF - 7pp US3853832  1974-12 Li  Harmone Research Foundation SYNTHETIC HUMAN PITUITARY GROWTH HORMONE AND METHOD OF PRODUCING IT
Get PDF - 11pp US3853833  1974-10 Li  Hormone Research Foundation SYNTHETIC HUMAN GROWTH-PROMOTING AND LACTOGENIC HORMONES AND METHOD OF PRODUCING SAME
Get PDF - 12pp US4110322  1978-08 Greven et al.  Akzona Incorporated Peptide derivatives and pharmaceutical compositions containing same
Get PDF - 35pp US4190495  1980-02 Curtiss, III  Research Corporation Modified microorganisms and method of preparing and using same
Get PDF - 10pp US4237224  1980-12 Cohen  Board of Trustees of the Leland Stanford Jr. University Process for producing biologically functional molecular chimeras
Get PDF - 7pp US4321365  1982-03 Wu et al.  Research Corporation Oligonucleotides useful as adaptors in DNA cloning, adapted DNA molecules, and methods of preparing adaptors and adapted molecules
Get PDF - 4pp US4332892  1982-06 Ptashne et al.  President and Fellows of Harvard College Protein synthesis
Get PDF - 13pp US4342832  1982-08 Goeddel  Genentech, Inc. Method of constructing a replicable cloning vehicle having quasi-synthetic genes
Get PDF - 24pp US4356270  1982-10 Itakura et al.  Genentech, Inc. Recombinant DNA cloning vehicle
Get PDF - 32pp US4363877  1982-12 Goodman et al.  The Regents of the University of California Recombinant DNA transfer vectors
Get PDF - 24pp US4366246  1982-12 Riggs  Genentech, Inc. Method for microbial polypeptide expression
Get PDF - 20pp US4407948  1983-10 Goodman et al.  The Regents of the University of California Purification of nucleotide sequences suitable for expression in bacteria
Get PDF - 9pp US4565785  1986-01 Gibert et al.  The President and Fellows of Harvard College Recombinant DNA molecule
Get PDF - 13pp US4601980  1986-07 Goeddel et al.  Genentech Inc. Microbial expression of a gene for human growth hormone
Get PDF - 13pp US4634677  1987-01 Goeddel et al.  Genentech, Inc. Plasmid capable of expressing human growth hormone
Get PDF - 12pp US4652525  1987-03 Rutter et al.  The Regents of the University of California Recombinant bacterial plasmids containing the coding sequences of insulin genes
Get PDF - 13pp US4898830  1990-02 Goeddel et al.  Genentech, Inc. Human growth hormone DNA
       
Foreign References:
Buy
PDF		 Publication Date IPC Code Assignee   Title
Get PDF - 18pp EP0006694 1980-01  C12N 15/09 HARVARD COLLEGE Method of making a selected protein 
Get PDF - 27pp EP0009930 1980-04  C12N 15/00 THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY Recombinant DNA, method for preparing it and production of foreign proteins by unicellular hosts containing it 
Get PDF - 57pp EP0012494 1980-06  C12N 15/00 THE REGENTS OF THE UNIVERSITY OF CALIFORNIA A DNA transfer vector, a microorganism modified by said vector and the synthesis of a eucaryotic protein by the modified microorganism 
Get PDF - 38pp EP0020147 1980-12  C12N 15/00 THE REGENTS OF THE UNIVERSITY OF CALIFORNIA A DNA transfer vector for human pre-growth hormone, a microorganism transformed thereby, and a method of cloning therefor 
Buy PDF GB1521032 1978-08  C07G 7/00 IMPERIAL CHEMICAL INDUSTRIES LTD BIOLOGICAL TREATMENT 
Buy PDF- 5pp GB2073245 1981-06  C07K 14/61 YEDA RES & DEV Production of Bovine Growth Hormone by Microorganisms 


Other Abstract Info: CHEMABS 094(21)170974D DERABS C81-03727D

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    • Continuity Data:
    Application Number Filed Notes
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