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Title: US5424199: Human growth hormone
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Kind:		 US United States of America
A PATENT [FROM BEGIN UNTIL END 2000] or PATENT ISSUED AFTER 1ST PUB. WITHIN THE TVPP i

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17 pages

 
Inventor: GOEDDEL DAVID V; United States of America
HEYNEKER HERBERT L; United States of America

Assignee: GENENTECH INC United States of America
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Published / Filed: 1995-06-13 / 1994-05-27

Application Number: US1994000250639
IPC Code: Advanced: A61K 38/27; C07G 99/00; C07H 21/00; C07H 21/04; C07K 14/00; C07K 14/575; C07K 14/61; C12N 1/20; C12N 1/21; C12N 15/00; C12N 15/09; C12N 15/10; C12N 15/18; C12N 15/62; C12N 15/63; C12N 15/64; C12N 15/66; C12N 15/70; C12N 15/72; C12P 19/34; C12P 21/00; C12P 21/02; C12R 1/125; C12R 1/19; C12R 1/42; C12R 1/46;
Subclass: C12N;
C12P;

ECLA Code: C12N15/66; C07K14/61; C12N15/10; C12N15/62; C12N15/70; M07K319/00; M07K319/02; M07K319/50; M07K319/75;

U.S. Class: 435/069.4; 435/069.1; 435/069.7; 435/320.1; 435/091.1; 435/091.4; 435/091.42; 435/091.5; 435/172.3; 935/009; 935/013; 935/029; 935/056; 935/038; 935/060; 935/073;

Priority Number:
1994-05-27  US1994000250639
1993-04-26  US1993000053839
1992-03-26  US1992000859285
1989-08-14  US1989000393808
1987-04-13  US1987000037319
1984-09-25  US1984000654340
1982-03-09  US1982000356564
1979-07-05  US1979000055126

Abstract:     Described are methods and means for the construction and microbial expression of quasi-synthetic genes arising from the combination of organic synthesis and enzymatic reverse transcription from messenger RNA sequences incomplete from the standpoint of the desired protein product. Preferred products of expression lack bio-inactivating leader sequences common in eukaryotic expression products but problematic with regard to microbial cleavage to yield bioactive material. Illustrative is a preferred embodiment in which a gene coding for human growth hormone (useful in, e.g., treatment of hypopituitary dwarfism) is constructed and expressed.

Maintenance Status: E3 Expired  Check current status
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INPADOC Legal Status:
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2007-07-31 FP - Expired due to failure to pay maintenance fee   ( 2007-06-13 )
2007-06-13 LAPS - Lapse for failure to pay maintenance fees  
2006-12-27 REMI Maintenance fee reminder mailed  
2002-11-15 FPAY + Fee payment  
1998-12-07 FPAY + Fee payment  
1997-11-11 CC Certificate of correction  

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Related Applications: Go to Result Set: 1 patent(s) that list this one as related
Application Number Filed Patent Pub. Date  Title
     1990-02-06  Human growth hormone DNA
     1987-04-14  Methionyl human growth hormone
     1986-07-22  Microbial expression of a gene for human growth hormone
     1982-08-03  Method of constructing a replicable cloning vehicle having quasi-synthetic genes


       
Parent Case:     This is a continuation of application Ser. No. 08/053,839, filed Apr. 26, 1993, now abandoned, which is a continuation of application Ser. No. 07/859,285 filed Mar. 26, 1992, now abanoned, which is a continuation of application Ser. No. 07/393,808 filed Aug. 14, 1989, now abandoned, which is a continuation of application Ser. No. 07/037,319 filed Apr. 13, 1987, now U.S. Pat. No. 4,898,830, which is a continuation of Ser. No. 06,654,340 filed Sep. 25, 1984, now U.S. Pat. No. 4,658,021, which is a divisional of application Ser. No. 06/356,564 filed Mar. 9, 1982, now U.S. Pat. No. 4,601,980, which is a divisional of application Ser. No. 06/055,124 filed Jul. 5, 1979, now U.S. Pat. No. 4,342,832.

Designated Country: NL SE  SU 

       
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  175 family members shown above     - Based on data when this patent issued.


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Other Abstract Info: CHEMABS 094(21)170974D DERABS C81-03727D

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