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 Title: |
US5424218:
Screening method for neuroprotective compounds
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Miljanich, George P.; Redwood City, CA
Bitner, Robert S.; Mountain View, CA
Bowersox, Stephen S.; Menlo Park, CA
Fox, James A.; Palo Alto, CA
Valentino, Karen L.; San Carlos, CA
Yamashiro, Donald H.; San Francisco, CA
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| Assignee: |
Neurex Corporation, Menlo Park, CA
other patents from NEUREX CORPORATION (397535) (approx. 15)
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| Published / Filed: |
1995-06-13
/ 1993-11-04
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| Application Number: |
US1993000147714
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| IPC Code: |
Advanced:
C07K 14/435;
A61K 38/00;
Core:
more...
IPC-7:
A61K 49/00;
G01N 33/567;
G01N 33/68;
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| ECLA Code: |
C07K14/435;
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| U.S. Class: |
Current:
436/503;
424/009.2;
435/029;
436/086;
Original:
436/503;
424/009.2;
435/029;
436/086;
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| Field of Search: |
514/012,13,14
530/324,325,326
436/503,86
424/2;9
435/029
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| Priority Number: |
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| Abstract: |
A partially purified omega conotoxin binding protein is disclosed. The protein, either in partially purified form or in a synaptosomal preparation, is useful in identifying compounds for use in reducing neuronal damage related to an ischemic condition, such as stroke, in a human patient.
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| Attorney, Agent or Firm: |
Dehlinger, Peter J. ;
Stratford, Carol A. ;
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| Primary / Asst. Examiners: |
Russel, Jeffrey E.;
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| INPADOC Legal Status: |
Show legal status actions
Family Legal Status Report
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| Parent Case: |
This is a continuation of application Ser. No. 07/855,269, (now U.S. Pat. No. 5,264,371) , filed Mar. 23, 1992, which is a division of application Ser. No. 07/561,766, filed Aug. 02, 1990 (now U.S. Pat. 5,189,020), which is a Continuation-in-Part of application Ser. No.07/440,094, filed Nov. 22, 1989 (now U.S. Pat. No. 5,051,403).
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| Designated Country: |
BE CH FR GB IT LI LU NL SE HU KR NO SU
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| Family: |
Show 23 known family members
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First Claim:
Show all 3 claims |
It is claimed:
1. A method of selecting a compound for use in reducing neuronal damage resulting from ischemic conditions in a human, comprising
- measuring the binding affinity of a compound to an omega conotoxin MVIIA binding site and the ability of the compound to inhibit voltage-gated calcium currents in cells containing neuronal calcium channels, and
- selecting the compound for use in reducing neuronal damage resulting from an ischemic condition if its binding affinity to the binding site and its specific activity in inhibiting voltage-gated calcium currents are at least as great as that of an omega conotoxin selected from the group consisting of MVIIA, MVIIB, GVIA, GVIIA and RVIA omega conotoxins.
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| Background / Summary: |
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| Drawing Descriptions: |
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| Description: |
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| Forward References: |
Show 24 U.S. patent(s) that reference this one
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| Foreign References: |
None
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| Other Abstract Info: |
CHEMABS 115(25)270696K
DERABS C1995-223694
CHEMABS 119(17)174217S
CHEMABS 125(23)293039U
DERABS C1991-192969
DERABS C1993-085564
DERABS C1993-385665
DERABS C1995-223694
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| Other References: |
Science, vol. 230, issued 20 Dec. 1985, Olivera et al, "Peptide Neurotoxins from Fish-Hunting Cone Snails", pp. 1338-1343.
(6 pages)
Cited by 25 patents
Bean, B. P., "Classes of Calcium Channels in Vertebrate Cells," Annu. Rev. Physiol. 51:367-384 (1989).
(18 pages)
Cited by 37 patents
Choi, D. W., "Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage," TINS 11(10):465-469 (1988).
(5 pages)
Cited by 10 patents
Gray, W. R., et al., "Peptide Toxins from Venomous Conus Snails," Ann. Rev. Biochem. 57:665-700 (1988).
(36 pages)
Cited by 11 patents
Hamilton, S. L., and Perez, M., "Toxins that Affect Voltage-Dependent Calcium Channels," Biochem. Pharmacol. 36(20):3325-3329 (1987).
(5 pages)
Cited by 2 patents
Jones, O. T., et al., "Localization and Mobility of ω-Coonotoxin-Sensitive Ca2+ Channels in Hippocampal CA1 Neurons," Science 244:1189-1193 (1989).
(5 pages)
Cited by 4 patents
Marqueze, B., et al., "Characterization of the ω-Conotoxin-Binding Molecule in Rat Brain Synaptosomes and Cultured Neurons," Mol. Pharmacol. 34:87-90 (1988).
(4 pages)
Cited by 3 patents
Olivera, B. M., et al., "Neuronal Calcium Channel Antagonists. Discrimination between Calcium Channel Subtypes Using ω-Conotoxin from Conus magus Venom," Biochem. 26:2086-2090 (1987).
(5 pages)
Cited by 19 patents
Takemura M., et al., "Distribution of the ω-Conotoxin Receptor in Rat Brain. An Autoradiographic Mapping," Neuroscience 32:405-416 (1989).
(12 pages)
Cited by 2 patents
Tsien, R. W., et al., "Multiple types of neuronal calcium channels and their selective modulation," TINS 11(10):431-438 (1988).
(8 pages)
Cited by 9 patents
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