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 Title: |
US5429921:
Assays for agonists and antagonists of recombinant human calcium channels
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Harpold, Michael M.; San Diego, CA
Ellis, Steven B.; San Diego, CA
Williams, Mark E.; Carlsbad, CA
Feldman, Daniel H.; San Diego, CA
McCue, Ann F.; La Mesa, CA
Brenner, Robert; Austin, TX
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| Assignee: |
The Salk Institute Biotechnology/Industrial Assoc. Inc., La Jolla, CA
other patents from SALK INSTITUTE BIOTECHNOLOGY/INDUSTRIAL ASSOCIATES, INC. (490310) (approx. 25)
News, Profiles, Stocks and More about this company
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| Published / Filed: |
1995-07-04
/ 1991-08-15
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| Application Number: |
US1991000745206
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| IPC Code: |
Advanced:
C07K 14/705;
C12Q 1/68;
G01N 33/564;
G01N 33/68;
A61K 38/00;
Core:
C07K 14/435;
more...
IPC-7:
C12Q 1/02;
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| ECLA Code: |
C07K14/705; C12Q1/68M; C12Q1/68P; G01N33/564; G01N33/68; G01N33/68V;
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| U.S. Class: |
Current:
435/004;
435/007.2;
435/069.1;
Original:
435/004;
435/069.1;
435/240.2;
435/007.2;
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| Field of Search: |
435/7.21,69.1,91,172.1,172.3,240.1,320.1
530/350,395
536/23.2
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| Priority Number: |
| 1991-08-15 |
US1991000745206 |
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| Abstract: |
Human calcium channel alpha 1-, alpha 2-, beta - and gamma -subunit encoding cDNAs, and related compositions and methods, are provided.
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| Attorney, Agent or Firm: |
Brown, Martin, Haller & McClain ;
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| Primary / Asst. Examiners: |
Draper, Garnette D.; Fitzgerald, David L.
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| INPADOC Legal Status: |
Show legal status actions
Family Legal Status Report
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| Parent Case: |
This application is a continuation-in-part of U.S. Ser. No. 620,250, filed Nov. 30, 1990, now abandoned, which is a continuation-in-part of U.S. Ser. No. 176,899, filed Apr. 4, 1988, now abandoned, and is also a continuation-in-part of U.S. Ser. No. 482,384, filed Feb. 20, 1990, now U.S. Pat. No. 5,386,025, and is also a continuation-in-part of U.S. Ser. No. 603,751, filed Apr. 4, 1989 as PCT/US89/01408 (U.S. application filed under 35 U.S.C. § 371 on Nov. 8, 1990), now abandoned, which is also a continuation-in-part of said application Ser. No. 176,899.
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| Designated Country: |
BB BG BR CS HU KP KR LK MG MN MW OA PL RO RU SD BE CH FR GB IE IT LI LU MC NL SE
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| Family: |
Show 84 known family members
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First Claim:
Show all 29 claims |
What is claimed is:
1. A method for testing a compound for activity as an agonist or antagonist of a calcium channel, comprising the steps of:
- suspending a eukaryotic cell expressing functional, heterologous calcium channels in a solution which contains the compound and an ion or molecule capable of entering the cell through a functional calcium channel;
- depolarizing the cell membrane of the cell;
- detecting the current flowing into the cell; and
- comparing the current thus detected to a current produced by cells in a control experiment; wherein:
- the only heterologous ion channels expressed by the cells are calcium channels which comprise one or more subunits;
- each heterologously expressed calcium channel subunit has the amino acid sequence of a naturally occurring human calcium channel subunit; and
- the heterologous calcium channels comprise at least a heterologous α1 subunit that is selected from the group consisting of
- a VDCC type II (α1C) subunit having an amino acid sequence comprising the sequence of amino acids set forth in SEQ ID NO: 7,
- a VDCC type III (α1D) subunit having an amino acid sequence comprising the sequence shown as amino acids 11-2161 of SEQ ID NO: 2, and
- a calcium channel α1 subunit encoded by DNA capable of hybridizing under conditions of high stringency with DNA that is complementary to an mRNA transcript present in a human cell and that encodes one of the aforesaid VDCC type II or type III subunits.
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| Background / Summary: |
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| Drawing Descriptions: |
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| Description: |
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| Forward References: |
Show 29 U.S. patent(s) that reference this one
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| Foreign References: |
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| Other Abstract Info: |
CHEMABS 113(07)053684J
CHEMABS 116(05)035641A
CHEMABS 119(17)176290J
CHEMABS 130(06)062686Q
CHEMABS 130(15)192775D
CHEMABS 133(11)145913Z
DERABS C1989-324236
DERABS C1991-281409
DERABS C1993-093936
DERABS C1995-161088
DERABS C1997-225431
DERABS C1997-558134
DERABS C1998-109869
DERABS C1998-456192
DERABS C2000-146548
DERABS C2000-548230
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| Other References: |
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[ISI abstract]
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[ISI abstract]
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[ISI abstract]
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[ISI abstract]
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[ISI abstract]
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[ISI abstract]
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| Continuity Data: |
| Application Number | Filed | Notes |
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US1991000745206 | 1991-08-15 | is a
related to the prior publication |
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US20070244297A1 issued 2007-10-18 Human calcium channel compositions and methods
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US2007000702388 | 2007-02-05 | is a
continuation of |
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US2003000375253
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US20040018510A1 issued 2004-01-29 Human calcium channel compositions and methods
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11702388 | | is a
continuation of |
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US2003000375253
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US20040018510A1 issued 2004-01-29 Human calcium channel compositions and methods
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US2003000375253 | 2003-02-27 | is a
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US1995000450273
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US6653097 issued 2003-11-25 Human calcium channel compositions and methods
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US2003000375253 | | is a
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US1995000450273
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US6653097 issued 2003-11-25 Human calcium channel compositions and methods
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US1992000914231 | | is a
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US1995000404950
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US7063950 issued 2006-06-20 Nucleic acids encoding human calcium channel and methods of use thereof
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US1990000482384 | | is a
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US1995000404950
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US7063950 issued 2006-06-20 Nucleic acids encoding human calcium channel and methods of use thereof
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US1995000450273 | 1995-05-25 | is a
continuation in part of |
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US1995000404354
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US5618720 issued 1997-04-08 Cells expressing calcium channel alpha 2 subunit-encoding DNA, optionally with a reporter gene for screening assays
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US1995000450273 | | is a
continuation in part of |
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US1995000404354
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US5618720 issued 1997-04-08 Cells expressing calcium channel alpha 2 subunit-encoding DNA, optionally with a reporter gene for screening assays
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US2007000702388 | 2007-02-05 | is a
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US1994000336257
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US5726035 issued 1998-03-10 Recombinant production of mammalian calcium channel gamma subunits
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11702388 | | is a
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US1994000336257
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US5726035 issued 1998-03-10 Recombinant production of mammalian calcium channel gamma subunits
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|
|
|
US1995000404354 | 1995-02-15 | is a
continuation of |
|
US1994000314083
| 1994-09-28 |
(granted)
|
| |
US5686241 issued 1997-11-11 Probes and assays for calcium channel alpha 2 subunit-encoding nucleic acids
|
|
|
|
US1992000914231 | | is a
continuation of |
|
US1994000314083
| 1994-09-28 |
|
| |
US5686241 issued 1997-11-11 Probes and assays for calcium channel alpha 2 subunit-encoding nucleic acids
|
|
|
|
US2007000702388 | 2007-02-05 | is a
continuation in part of |
|
US1994000311363
| 1994-09-23 |
(granted)
|
| |
US5876958 issued 1999-03-02 Assays of cells expressing human calcium channels containing α1 β subunits
|
|
|
|
>US1991000745206< | | is a
continuation in part of |
|
US1994000311363
| 1994-09-23 |
|
| |
US5876958 issued 1999-03-02 Assays of cells expressing human calcium channels containing α1 β subunits
|
|
|
|
US2007000702388 | 2007-02-05 | is a
continuation in part of |
|
US1994000290012
| 1994-08-11 |
(abandoned)
|
|
|
11702388 | | is a
continuation in part of |
|
US1994000290012
| 1994-08-11 |
(abandoned)
|
|
|
US2007000702388 | 2007-02-05 | is a
continuation in part of |
|
US1994000223305
| 1994-04-04 |
(granted)
|
| |
US5851824 issued 1998-12-22 Human calcium channel alpha -1C/ alpha -1D, alpha -2, beta -1, and gamma subunits and cells expressing the DNA
|
|
|
|
11702388 | | is a
continuation in part of |
|
US1994000223305
| 1994-04-04 |
|
| |
US5851824 issued 1998-12-22 Human calcium channel alpha -1C/ alpha -1D, alpha -2, beta -1, and gamma subunits and cells expressing the DNA
|
|
|
|
US2007000702388 | 2007-02-05 | is a
continuation in part of |
|
US1994000193078
| 1994-02-07 |
(granted)
WO1992US0006903
|
| |
US5846757 issued 1998-12-08 Human calcium channel alpha 1, alpha 2, and beta subunits and assays using them
|
|
|
|
US1995000404950 | | is a
continuation in part of |
|
US1994000193078
| |
|
| |
US5846757 issued 1998-12-08 Human calcium channel alpha 1, alpha 2, and beta subunits and assays using them
|
|
|
|
11702388 | | is a
continuation in part of |
|
US1994000193078
| |
|
| |
US5846757 issued 1998-12-08 Human calcium channel alpha 1, alpha 2, and beta subunits and assays using them
|
|
|
|
US2007000702388 | 2007-02-05 | is a
continuation in part of |
|
US1993000149097
| 1993-11-05 |
(granted)
|
| |
US5874236 issued 1999-02-23 DNA encoding human calcium channel alpha -1A, beta 1, beta -2, and beta -4 subunits, and assays using cells that express the subunits
|
|
|
|
US1994000290012 | 1994-08-11 | is a
continuation in part of |
|
US1993000149097
| 1993-11-05 |
(granted)
|
| |
US5874236 issued 1999-02-23 DNA encoding human calcium channel alpha -1A, beta 1, beta -2, and beta -4 subunits, and assays using cells that express the subunits
|
|
|
|
US1994000290012 | | is a
continuation in part of |
|
US1993000149097
| 1993-11-05 |
|
| |
US5874236 issued 1999-02-23 DNA encoding human calcium channel alpha -1A, beta 1, beta -2, and beta -4 subunits, and assays using cells that express the subunits
|
|
|
|
11702388 | | is a
continuation in part of |
|
US1993000149097
| 1993-11-05 |
|
| |
US5874236 issued 1999-02-23 DNA encoding human calcium channel alpha -1A, beta 1, beta -2, and beta -4 subunits, and assays using cells that express the subunits
|
|
|
|
US2007000702388 | 2007-02-05 | is a
continuation in part of |
|
US1993000105536
| 1993-08-11 |
(abandoned)
|
|
|
US1994000290012 | 1994-08-11 | is a
continuation in part of |
|
US1993000105536
| 1993-08-11 |
(abandoned)
|
|
|
US1994000193078 | | is a
continuation of |
|
US1993000105536
| 1993-08-11 |
(abandoned)
|
|
|
US1993000149097 | 1993-11-05 | is a
continuation in part of |
|
US1993000105536
| 1993-08-11 |
(abandoned)
|
|
|
US1993000149097 | | is a
continuation in part of |
|
US1993000105536
| 1993-08-11 |
(abandoned)
|
|
|
US2007000702388 | 2007-02-05 | is a
continuation in part of |
|
US1992000914231
| 1992-07-13 |
(granted)
|
| |
US5407820 issued 1995-04-18 Calcium channel alpha -2 subunit DNAs and cells expressing them
|
|
|
|
US1995000404950 | | is a
continuation in part of |
|
US1992000914231
| 1992-07-13 |
|
| |
US5407820 issued 1995-04-18 Calcium channel alpha -2 subunit DNAs and cells expressing them
|
|
|
|
US1995000404354 | 1995-02-15 | is a
continuation of |
|
US1992000914231
| 1992-07-13 |
(granted)
|
| |
US5407820 issued 1995-04-18 Calcium channel alpha -2 subunit DNAs and cells expressing them
|
|
|
|
US1995000404354 | | is a
continuation of |
|
US1992000914231
| 1992-07-13 |
|
| |
US5407820 issued 1995-04-18 Calcium channel alpha -2 subunit DNAs and cells expressing them
|
|
|
|
US1994000314083 | 1994-09-28 | is a
division of |
|
US1992000914231
| 1992-07-13 |
(granted)
|
| |
US5407820 issued 1995-04-18 Calcium channel alpha -2 subunit DNAs and cells expressing them
|
|
|
|
US1994000314083 | | is a
division of |
|
US1992000914231
| 1992-07-13 |
|
| |
US5407820 issued 1995-04-18 Calcium channel alpha -2 subunit DNAs and cells expressing them
|
|
|
|
US1993000105536 | | is a
continuation in part of |
|
US1992000914231
| 1992-07-13 |
|
| |
US5407820 issued 1995-04-18 Calcium channel alpha -2 subunit DNAs and cells expressing them
|
|
|
|
US2007000702388 | 2007-02-05 | is a
continuation in part of |
|
US1992000868354
| 1992-04-10 |
(abandoned)
|
|
|
US1994000223305 | 1994-04-04 | is a
continuation of |
|
US1992000868354
| 1992-04-10 |
(abandoned)
|
|
|
US1994000223305 | | is a
continuation of |
|
US1992000868354
| 1992-04-10 |
(abandoned)
|
|
|
US1994000193078 | | is a
continuation in part of |
|
US1992000868354
| 1992-04-10 |
(abandoned)
|
|
|
US1993000105536 | | is a
continuation in part of |
|
US1992000868354
| 1992-04-19 |
(abandoned)
|
|
|
US1992000914231 | | is a
continuation in part of |
|
US1992000868354
| 1992-04-10 |
(abandoned)
|
|
|
US2007000702388 | 2007-02-05 | is a
continuation in part of |
|
>US1991000745206<
| 1991-08-15 |
(granted)
|
| |
US5429921 issued 1995-07-04 Assays for agonists and antagonists of recombinant human calcium channels
|
|
|
|
US1994000311363 | 1994-09-23 | is a
continuation of |
|
>US1991000745206<
| 1991-08-15 |
(granted)
|
| |
US5429921 issued 1995-07-04 Assays for agonists and antagonists of recombinant human calcium channels
|
|
|
|
US1994000311363 | | is a
continuation of |
|
>US1991000745206<
| 1991-08-15 |
|
| |
US5429921 issued 1995-07-04 Assays for agonists and antagonists of recombinant human calcium channels
|
|
|
|
US1992000868354 | 1992-04-10 | is a
continuation in part of |
|
>US1991000745206<
| 1991-08-15 |
(granted)
|
| |
US5429921 issued 1995-07-04 Assays for agonists and antagonists of recombinant human calcium channels
|
|
|
|
US1992000868354 | | is a
continuation in part of |
|
>US1991000745206<
| 1991-08-15 |
|
| |
US5429921 issued 1995-07-04 Assays for agonists and antagonists of recombinant human calcium channels
|
|
|
|
US2007000702388 | 2007-02-05 | is a
continuation in part of |
|
US1990000620250
| 1990-11-30 |
(abandoned)
|
|
|
>US1991000745206< | 1991-08-15 | is a
continuation in part of |
|
US1990000620250
| 1990-11-30 |
(abandoned)
|
|
|
>US1991000745206< | | is a
continuation in part of |
|
US1990000620250
| 1990-11-30 |
(abandoned)
|
|
|
US1990000603751 | | is a
continuation in part of |
|
US1990000620250
| 1990-11-30 |
(abandoned)
|
|
|
US1988000176899 | | is a
continuation in part of |
|
US1990000620250
| 1990-11-30 |
(abandoned)
|
|
|
US2007000702388 | 2007-02-05 | is a
continuation in part of |
|
US1990000603751
| 1990-11-08 |
(abandoned)
|
|
|
US1993000105536 | 1993-08-11 | is a
continuation in part of |
|
US1990000603751
| 1990-11-08 |
(abandoned)
|
|
|
US1993000105536 | | is a
continuation in part of |
|
US1990000603751
| 1990-11-08 |
(abandoned)
|
|
|
US1992000914231 | 1992-07-13 | is a
continuation of |
|
US1990000603751
| 1990-11-08 |
(abandoned)
|
|
|
US1992000914231 | | is a
continuation of |
|
US1990000603751
| 1990-11-08 |
(abandoned)
|
|
|
US1992000914231 | | is a
continuation in part of |
|
US1990000603751
| 1990-11-08 |
(abandoned)
|
|
|
>US1991000745206< | 1991-08-15 | is a
continuation in part of |
|
US1990000603751
| 1990-11-08 |
(abandoned)
|
|
|
>US1991000745206< | | is a
continuation in part of |
|
US1990000603751
| 1990-11-08 |
(abandoned)
|
|
|
US2007000702388 | 2007-02-05 | is a
continuation in part of |
|
US1990000482384
| 1990-02-20 |
(granted)
|
| |
US5386025 issued 1995-01-31 Calcium channel compositions and methods
|
|
|
|
US1994000336257 | 1994-11-07 | is a
continuation of |
|
US1990000482384
| 1990-02-20 |
(granted)
|
| |
US5386025 issued 1995-01-31 Calcium channel compositions and methods
|
|
|
|
US1994000336257 | | is a
continuation of |
|
US1990000482384
| 1990-02-20 |
|
| |
US5386025 issued 1995-01-31 Calcium channel compositions and methods
|
|
|
|
US1990000620250 | | is a
continuation in part of |
|
US1990000482384
| 1990-02-20 |
|
| |
US5386025 issued 1995-01-31 Calcium channel compositions and methods
|
|
|
|
US2007000702388 | 2007-02-05 | is a
continuation in part of |
|
US1988000176899
| 1988-04-04 |
(abandoned)
|
|
|
US1990000603751 | | is a
continuation in part of |
|
US1988000176899
| 1988-04-04 |
(abandoned)
|
|
|
US1990000482384 | | is a
continuation in part of |
|
US1988000176899
| 1988-04-04 |
(abandoned)
|
|
|
US1995000404950 | | is a
continuation in part of |
|
PCT/US89/01408
| 1988-04-04 |
(pending)
|
|
|
US1994000311363 | | is a
continuation of |
|
11702388
| |
(pending)
|
|
|
US1993000105536 | | is a
continuation in part of |
|
11702388
| |
(pending)
|
|
|
US1992000914231 | | is a
continuation in part of |
|
11702388
| |
(pending)
|
|
|
US1990000620250 | | is a
continuation in part of |
|
11702388
| |
(pending)
|
|
|
US1990000603751 | | is a
continuation in part of |
|
11702388
| |
(pending)
|
|
|
 Nominate this for the Gallery...
|
|
