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 Title: |
US5432155:
Conotoxins I
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Olivera, Baldomero M.; Salt Lake City, UT
Rivier, Jean E. F.; La Jolla, CA
Cruz, Lourdes J.; Salt Lake City, UT
Abogadie, Fe; Evanston, IL
Hopkins, Chris E.; Salt Lake City, UT
Dykert, John; Vista, CA
Torres, Josep L.; Barcelona, Spain
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| Assignee: |
The Salk Institute For Biological Studies, San Diego, CA
University of Utah Research Foundation, Salt Lake City, UT
other patents from SALK INSTITUTE FOR BIOLOGICAL STUDIES (490315) (approx. 349)
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| Published / Filed: |
1995-07-11
/ 1993-06-29
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| Application Number: |
US1993000084848
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| IPC Code: |
Advanced:
C07K 14/435;
C12N 15/12;
A61K 38/00;
A61K 39/00;
Core:
more...
IPC-7:
A61K 38/10;
A61K 38/17;
C07K 7/08;
C07K 14/435;
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| ECLA Code: |
C07K14/435;
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| U.S. Class: |
Current:
514/012;
514/013;
530/324;
530/325;
530/326;
Original:
514/012;
514/013;
530/324;
530/325;
530/326;
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| Field of Search: |
530/324-326
514/012,13
536/23.5
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| Government Interest: |
This invention was made with Government support under Grant Nos. GM-22737 and AM-26741, awarded by the National Institutes of Health. The Government has certain rights in this invention.
This invention relates to relatively short peptides, and more particularly to peptides between about 16 and about 46 residues in length, which are naturally available in minute amounts in the venom of the cone snails and which may include one or more cyclizing disulfide linkages.
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| Priority Number: |
| 1993-06-29 |
US1993000084848 |
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| Abstract: |
Substantially pure conotoxins are provided which inhibit synaptic transmissions at the neuromuscular junctions and which are useful both in vivo and in assays because they specifically target particular receptors, such as the acetylcholine receptor, and ion channels. The peptides are of such length that they can be made by chemical synthesis. They also may be made using recombinant DNA techniques, and the DNA encoding such conotoxins having pesticidal properties can be incorporated as plant defense genes into plant species of interest.
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| Attorney, Agent or Firm: |
Fitch, Even, Tabin & Flannery ;
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| Primary / Asst. Examiners: |
Furman, Keith C.;
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| Maintenance Status: |
CC Certificate of Correction issued
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| INPADOC Legal Status: |
Show legal status actions
Family Legal Status Report
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| Designated Country: |
AT BE CH DE DK FR GB IT LI LU NL SE AU CA EP JP KR
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| Family: |
Show 49 known family members
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First Claim:
Show all 13 claims |
What is claimed is:
1. A substantially pure conotoxin having the formula:
Xaa1 -Cys-Cys-Gly-Xaa2 -Cys-Xaa3 -Xaa4 -Cys-Xaa5 -Cys-Xaa6 -Cys-Xaa7 -NH2 (SEQ ID NO: 14)
wherein Xaa1 is des-Xaa1 or Gly or pGlu-Lys-Ser-Leu-Val-Pro-Ser-Val-Ile-Thr-Thr; Xaa2 is Ser-Tyr-Pro-Asn-Ala-Ala or Tyr-Asp-4Hyp-Gly-Thr-Met or Val-4Hyp-Aun-Ala-Ala or Ser-Tyr-4Hyp-Asn-Ala-Ala; Xaa3 is His, 4Hyp or Pro; Xaa4 Pro or 4Hyp; Xaa5 is Ser, Arg or Val; Xaa6 is Lys-Asp-Arg-4Hyp-Ser-Tyr or Thr-Asn-Ser or Asn-Lys-Thr or Lys-Asn-Thr; and Xaa7 is des-Xaa7 or Gly or Gly-Gln.
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| Background / Summary: |
Show background / summary
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| Drawing Descriptions: |
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| Description: |
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| Forward References: |
Show 35 U.S. patent(s) that reference this one
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| Foreign References: |
None
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| Other Abstract Info: |
CHEMABS 123(05)050449G
CHEMABS 125(03)028184M
CHEMABS 126(12)152786U
CHEMABS 126(14)182612B
DERABS C1995-061000
DERABS C1997-076840
DERABS C1997-309336
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| Other References: |
Rivier, et al., "Total Synthesis and Further Characterization of the γ-Carboxyglutamate-Containing `Sleeper` Peptide from Conus geographus Venom", Biochemistry, 1987, 26, 8508-8512.
(5 pages)
Cited by 3 patents
Penke et al., "Solid-Phase Synthesis of Peptide Amides on a Polystyrene Support Using Fluorenylmethoxycarbonyl Protecting Groups", J. Org. Chem., 1987, 52, 1197-1200.
(4 pages)
Cited by 5 patents
Mena, et al., "Conantokin-G: a novel peptide antagonist to the N-methyl-D-aspartic acid (NMDA) receptor", Neuroscience Letters, 118 (1990) 241-244.
(4 pages)
Cited by 11 patents
Haack, et al., "Conantokin-T-A γ-Carboxyglutamate Containing Peptide with N-Methyl-D-Aspartate Antagonist Activity", The Journal of Biological Chemistry, vol. 265, No. 11, pp. 6025-6029, Apr. 15, 1990.
(5 pages)
Cited by 8 patents
Olivera, et al., "Diversity of Conus Neuropeptides", Science, vol. 249, pp. 257-263, Jul. 20, 1990.
(7 pages)
Cited by 36 patents
Olivera, et al., "Conotoxins", J. Biol. Chem., vol. 266, No. 33, pp. 22067-22070, Nov. 25, 1991.
(4 pages)
Cited by 30 patents
[ISI abstract]
Olivera, et al., "Conus Peptides and Biotechnology", Neurotox '91, pp. 45-55, Molecular Basis of Drug & Pesticide Action, Elsevier Sci. Publishers, Ltd., Essex, England 1992.
Torres, et al., "Structure-Activity Studies of Conantokin-G Analogs", Thirteenth American Peptide Symposium, Jun. 1993, Abstract P421.
Gray, W. R. "Multicyclic Cystine Peptides: A New Method for Disulfide Analysis", Thirteenth American Peptide Symposium, Jun. 1993, Abstract Wk5.
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| Continuity Data: |
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