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 Title: |
US5441739:
Reduced and controlled surface binding of biologically active molecules
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Kossovsky, Nir; Los Angeles, CA
Gelman, Andrew E.; Los Angeles, CA
Sponsler, Edward E.; Burbank, CA
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| Assignee: |
The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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| Published / Filed: |
1995-08-15
/ 1993-03-11
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| Application Number: |
US1993000029896
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| IPC Code: |
Advanced:
A61K 9/00;
A61K 9/127;
A61K 9/51;
A61K 38/28;
A61K 38/40;
A61K 38/42;
A61K 38/48;
A61K 39/12;
A61K 39/21;
A61K 47/26;
A61K 47/48;
A61K 48/00;
A61L 31/10;
C07K 14/05;
C07K 14/16;
C12N 11/14;
C12N 15/87;
A61K 38/00;
Core:
A61K 38/41;
A61K 38/43;
A61L 31/08;
C07K 14/005;
C12N 11/00;
more...
IPC-7:
A61K 9/00;
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| ECLA Code: |
A61K9/00M5F; A61K9/00M5; A61K9/127; A61K9/51; A61K38/28; A61K38/40; A61K38/42; A61K38/48; A61K39/21; A61K47/26; A61K47/48W14B; A61K48/00; A61L31/10; C07K14/05; C07K14/16; C12N11/14; C12N15/87;
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| U.S. Class: |
Current:
424/400;
424/422;
424/423;
424/461;
424/493;
424/494;
600/030;
604/008;
604/043;
604/327;
604/403;
604/891.1;
606/001;
606/014;
607/002;
Original:
424/400;
424/422;
424/423;
424/461;
424/493;
424/494;
600/030;
604/891.1;
604/008;
604/043;
604/327;
604/403;
606/001;
606/014;
607/002;
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| Field of Search: |
424/461,479,480,490,493,494,400
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| Priority Number: |
| 1993-03-11 |
US1993000029896 |
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| Abstract: |
Articles of manufacture which are adapted for use in contact with one or more biologically active agents are coated with a glassy carbohydrate film. The glassy film provides a reduced surface energy coating which exhibits a reduced degree of binding with biologically active agents. Methods for applying the glassy carbohydrate film are disclosed wherein the glassy film is adsorbed directly onto the article surface. The coated articles are for use both in vitro and in vivo where contact with biologically active agents is expected.
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| Attorney, Agent or Firm: |
Poms, Smith, Lande & Rose ;
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| Primary / Asst. Examiners: |
Page, Thurman K.; Spear, James M.
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| INPADOC Legal Status: |
Show legal status actions
Family Legal Status Report
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| Parent Case: |
This is a continuation-in-part of application, Ser. No. 8/000,199, which was filed on Jan. 4, 1993, now U.S. Pat. No. 5,334,394 which is a continuation-in-part of application, Ser. No. 07/690,601, filed Apr. 24, 1991, now U.S. Pat. No. 5,178,882, which is a continuation-in-part of application, Ser. No. 07/542,255, which was filed on Jun. 22, 1990, now U.S. Pat. No. 5,219,577.
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| Designated Country: |
BB BG BR BY CZ FI HU KP KR KZ LK LV MG MN MW NO NZ OA PL RO BE CH FR GB GR IT LI LU MC NL
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| Family: |
Show 58 known family members
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First Claim:
Show all 8 claims |
What is claimed is:
1. An article of manufacture which is adapted for use in contact with one or more biologically active agents, said article of manufacture being selected from the group consisting of containers, implant devices, electrodes, pumps, syringes, needles, conduits, applicators, bio/opto-electric devices, tubing, said article of manufacture comprising a surface, said surface comprising a ceramic, metal or polymer having a high surface energy wherein said surface binds to said biologically active agent or agents with a certain binding energy, the improvement comprising adsorbing directly to said surface a glassy carbohydrate film, said film consisting of an oligosaccharide selected from the group of sugars consisting of cellobiose, trehalose, isomaltose, and nystose or an allosteric effector, selected from the group consisting of pyridoxal-5-phosphate and 2,3-phosphoglycerate said glassy film having a surface energy which is below the surface energy of said surface to thereby provide a reduction in the binding energy between said surface and said biologically active agent or agents.
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| Background / Summary: |
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| Drawing Descriptions: |
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| Description: |
Show description
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| Forward References: |
Show 9 U.S. patent(s) that reference this one
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| Foreign References: |
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| Other Abstract Info: |
CHEMABS 116(11)104322M
CHEMABS 123(16)208983P
CHEMABS 120(26)331094Q
CHEMABS 123(16)208983P
CHEMABS 124(01)007065N
CHEMABS 124(04)037703M
CHEMABS 124(06)066600F
CHEMABS 124(06)066679P
DERABS C1992-010276
DERABS C1994-134687
DERABS C1994-248851
DERABS C1994-248855
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| Other References: |
Kossovsky, N. et al: "Nanocrystalline Epstein-Barr Virus Decoys," Jour. Appl. Biomaterials, vol. 2, 251-259 (1991).
(9 pages)
Cited by 5 patents
[ISI abstract]
Levine, H. and Slade, L.: "Another View of Trehalose for Drying and Stabilizing Biological Materials," BioPharm, (May 1992) pp. 36-40.
Crowe, J. H. et al.: "Interactions of sugars with membranes," Biochimica et Biophisica Acta, 947 (1988) 367-384.
(18 pages)
Cited by 10 patents
Fleminger, G. et al.: "Effect of polyethylene glycol on the non-specific adsorption of proteins to Eupergit C and agarose," Jour. Chromatography, 510 (1990) pp. 271-279.
(9 pages)
Cited by 2 patents
Bruin, G. J. M., et al.: "Performance of Carbohydrate-Modified Fused-Silica Capillaries for the Separation of Proteins by Zone Electrophoresis," Jour. Chromatography, 480 (1989) pp. 339-349.
(11 pages)
Cited by 4 patents
Hjerten, S.: "Free Zone Electrphoresis," Chromatographic Reviews, 9 (1967) pp. 122-219.
Hjerten, S.: "High-Performance Elctrophoresis Elimination of Electroendosmosis and Solute Adsorption," Jour. Chromatography, 347 (1985) pp. 191-198.
(8 pages)
Cited by 46 patents
McCormick, R. M.: "Capillary Zone Electrophoretic Separation of Peptides and Proteins Using Low pH Buffers in Modified Silica Capillaries," Anal. Chem. (1988), 60, pp. 2322-2328.
(7 pages)
Cited by 18 patents
Gordon, M. J. et al.: "Protocol for Resolving Protein Mixtures in Capillary Zone Electrophoresis," Anal. Chem. (1991), 63, pp. 69-72.
(4 pages)
Cited by 11 patents
[ISI abstract]
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