 |
|
|
|
|
|
 Title: |
US5459126:
Method for decreasing calcium uptake by cells using selected polycations
[ Derwent Title ]
>> View Certificate of Correction for this publication
|
| Country: |
US United States of America
|
| |
| Inventor: |
Langer, Glenn A.; Pacific Palisades, CA
Clague, Jonathan R.; London, United Kingdom
Post, Jan A.; Nieuwegein, Netherlands
|
| Assignee: |
California Institute of Technology, Pasadena, CA
other patents from CALIFORNIA INSTITUTE OF TECHNOLOGY (84480) (approx. 1,398)
News, Profiles, Stocks and More about this company
|
| Published / Filed: |
1995-10-17
/ 1993-05-21
|
| Application Number: |
US1993000065631
|
| IPC Code: |
Advanced:
A61K 31/14;
A61K 38/12;
A61K 38/17;
Core:
more...
IPC-7:
A61K 31/02;
A61K 31/14;
A61K 37/00;
|
| ECLA Code: |
A61K31/14; A61K38/12; A61K38/17;
|
| U.S. Class: |
Current:
514/002;
514/011;
514/012;
514/021;
514/642;
514/743;
Original:
514/002;
514/011;
514/642;
514/743;
514/012;
514/021;
|
| Field of Search: |
514/002,11,12,21,642,743
|
| Government Interest: |
BACKGROUND OF THE INVENTION
This invention was made with support under Grant Number 5R01 HL28539-10 from the National Institutes of Health. Accordingly, the U.S. Government has certain rights in the invention.
|
| Priority Number: |
| 1993-05-21 |
US1993000065631 |
|
| Abstract: |
A method for reducing calcium overload in cells to prevent the transition from reversible to irreversible injury. The cell surface is treated with an organic polycation selected from the group consisting of protamine, dodecyltrimethylammonium bromide, polymyxin B sulfate and polybrene which is capable of altering the cells surface charge sufficiently to eliminate or reduce the influx of calcium resulting from exposure to noxious stimuli. The method may be used both in vivo and in vitro. The method is effective in preventing calcium uptake in a variety of cell injury situations including metabolic inhibition and free radical attack.
|
| Attorney, Agent or Firm: |
Poms, Smith, Lande & Rose ;
|
| Primary / Asst. Examiners: |
Criares, Theodore J.;
|
| Maintenance Status: |
CC Certificate of Correction issued
View Certificate of Correction
|
| INPADOC Legal Status: |
Show legal status actions
Family Legal Status Report
|
| Designated Country: |
CA EP JP
|
| Family: |
Show 2 known family members
|
First Claim:
Show all 17 claims |
What is claimed is:
1. A method for reducing the uptake of calcium by a mammalian cell wherein said cell includes a surface having a surface charge, said method comprising the step of treating said cell surface with a sufficient amount of a cationic agent to alter the surface charge of said cell to reduce the uptake of calcium by said cell wherein said cationic agent is selected from the group consisting of protamine, dodecyltrimethylammonium bromide, polymyxin B sulfate and polybrene.
|
| Background / Summary: |
Show background / summary
|
| Drawing Descriptions: |
Show drawing descriptions
|
| Description: |
Show description
|
