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 Title: |
US5460830:
Biochemically active agents for chemical catalysis and cell receptor activation
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Kossovsky, Nir; Los Angeles, CA
Sponsler, Edward; Burbank, CA
Gelman, Andrew; Los Angeles, CA
Rajguru, Samir; Los Angeles, CA
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| Assignee: |
The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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| Published / Filed: |
1995-10-24
/ 1993-11-01
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| Application Number: |
US1993000145870
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| IPC Code: |
Advanced:
A61K 9/00;
A61K 9/127;
A61K 9/51;
A61K 38/28;
A61K 38/40;
A61K 38/42;
A61K 38/48;
A61K 39/12;
A61K 39/21;
A61K 47/26;
A61K 47/48;
A61K 48/00;
A61L 31/10;
C07K 14/05;
C07K 14/16;
C12N 11/14;
C12N 15/87;
A61K 38/00;
Core:
A61K 38/41;
A61K 38/43;
A61L 31/08;
C07K 14/005;
C12N 11/00;
more...
IPC-7:
A61K 9/16;
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| ECLA Code: |
A61K9/00M5F; A61K9/00M5; A61K9/127; A61K9/51; A61K38/28; A61K38/40; A61K38/42; A61K38/48; A61K39/21; A61K47/26; A61K47/48W14B; A61K48/00; A61L31/10; C07K14/05; C07K14/16; C12N11/14; C12N15/87;
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| U.S. Class: |
Current:
424/493;
424/094.3;
424/490;
424/494;
514/951;
514/970;
Original:
424/493;
424/094.3;
424/490;
424/494;
514/951;
514/970;
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| Field of Search: |
424/490,493,494
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| Priority Number: |
| 1993-11-01 |
US1993000145870 |
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| Abstract: |
A biologically active composition made up of core particles or surfaces which are coated with a layer which is designed to allow attachment of biochemically reactive pairs (BRP's) without denaturing the BRP to the microparticles. BRP's which may be attached include ligand-receptor pairs, enzyme-substrate pairs, drug-receptor pairs, catalyst-reactant pairs, toxin-ligand pairs, absorbant-absorbate pairs and adsorbant-adsorbate pairs.
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| Attorney, Agent or Firm: |
Poms, Smith, Lande & Rose ;
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| Primary / Asst. Examiners: |
Page, Thurman K.; Spear, James M.
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| INPADOC Legal Status: |
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Family Legal Status Report
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| Parent Case: |
BACKGROUND OF THE INVENTION
This is a continuation-in-part of application Ser. No. 08/000,199, now U.S. Pat. No. 5,334,394, which was filed on Jan. 4, 1993 which is a continuation-in-part of Ser. No. 07/690,601, filed Apr. 24, 1991, now U.S. Pat. No. 5,178,882, which is a continuation-in-part of application Ser. No. 07/542,255, filed Jun. 22, 1990, now U.S. Pat. No. 5,219,577.
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| Designated Country: |
BB BG BR BY CZ FI HU KP KR KZ LK LV MG MN MW NO NZ OA PL RO BE CH FR GB GR IT LI LU MC NL
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| Family: |
Show 58 known family members
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First Claim:
Show all 10 claims |
What is claimed is:
1. A biochemically active composition of matter comprising:
- an article having a surface selected from the group consisting of a metal, metal alloy, polymer, ceramic, glass or intermetallic;
- a coating located on said surface which provides a coated surface said coating consisting essentially of a substance which provides a threshold surface energy to said surface which is sufficient to bind biochemically reactive pairs without denaturing said pairs and said substance being selected from the group consisting of short chain carbohydrates, polymeric carbohydrates, nitrocellulose, pyridoxyl-5-pyrophosphate, thiamine pyrophosphate, uridine-diphosphate-glucose, glucose-1-phosphate, adenosine, nicotinamide-adenine-diphosphate, citrate, fumarate, succinate, isocitrate, oxaloacetate and malate; and
- at least one biochemically reactive pair bound to said coated surface wherein said biochemically reactive pair bound to said coated surface is not denatured to thereby provide said biochemically active composition.
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| Background / Summary: |
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| Drawing Descriptions: |
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| Description: |
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| Forward References: |
Show 11 U.S. patent(s) that reference this one
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