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 Title: |
US5460831:
Targeted transfection nanoparticles
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Kossovsky, Nir; Los Angeles, CA
Hnatyszyn, H. James; Los Angeles, CA
Gelman, Andrew; Los Angeles, CA
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| Assignee: |
The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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| Published / Filed: |
1995-10-24
/ 1993-11-04
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| Application Number: |
US1993000147751
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| IPC Code: |
Advanced:
A61K 9/00;
A61K 9/127;
A61K 9/51;
A61K 38/28;
A61K 38/40;
A61K 38/42;
A61K 38/48;
A61K 39/12;
A61K 39/21;
A61K 47/26;
A61K 47/48;
A61K 48/00;
A61L 31/10;
C07K 14/05;
C07K 14/16;
C12N 11/14;
C12N 15/87;
A61K 38/00;
Core:
A61K 38/41;
A61K 38/43;
A61L 31/08;
C07K 14/005;
C12N 11/00;
more...
IPC-7:
A61K 9/14;
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| ECLA Code: |
A61K9/00M5F; A61K9/00M5; A61K9/127; A61K9/51; A61K38/28; A61K38/40; A61K38/42; A61K38/48; A61K39/21; A61K47/26; A61K47/48W14B; A61K48/00; A61L31/10; C07K14/05; C07K14/16; C12N11/14; C12N15/87;
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| U.S. Class: |
Current:
424/493;
424/204.1;
424/490;
424/494;
424/498;
514/951;
514/970;
Original:
424/493;
424/490;
424/494;
424/498;
424/204.1;
514/951;
514/970;
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| Field of Search: |
424/493,494,490,498
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| Priority Number: |
| 1993-11-04 |
US1993000147751 |
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| Abstract: |
A biologically active composition for use in gene therapy and other transfection procedures. The composition is composed of nanocrystalline core particles which are coated with a layer that is designed to allow attachment of transfection agents (DNA/RNA segments or antisense fragments) without denaturing them. The composition may further include an exterior targeting membrane which provides selective targeting of the transfection agents to specific cell receptors.
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| Attorney, Agent or Firm: |
Poms, Smith, Lande & Rose ;
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| Primary / Asst. Examiners: |
Page, Thurman K.; Spear, James M.
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| Maintenance Status: |
CC Certificate of Correction issued
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| INPADOC Legal Status: |
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Family Legal Status Report
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| Parent Case: |
This is a continuation-in-part of application Ser. No. 08/000,199, now U.S. Pat. No. 5,334,394 which was filed on Jan. 4, 1993 which is a continuation-in-part of Ser. No. 07/690,601 which was filed on Apr. 24, 1991, now U.S. Pat. No. 5,178,882 which is a continuation-in-part of application Ser. No. 07/542,255 which was filed on Jun. 22, 1990, now U.S. Pat. No. 5,219,577.
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| Designated Country: |
BB BG BR BY CZ FI HU KP KR KZ LK LV MG MN MW NO NZ OA PL RO BE CH FR GB GR IT LI LU MC NL
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| Family: |
Show 58 known family members
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First Claim:
Show all 16 claims |
What is claimed is:
1. A composition of matter comprising:
- a biodegradable core particle having a diameter of less than about 1000 nanometers wherein said core particle comprises a biodegradable ceramic or polymer;
- a coating comprising a substance that provides a threshold surface energy to said core particle which is sufficient to bind transfection agents without denaturing said agents, said substance covering at least a part of the surface of said core particle and wherein said substance is selected from the group consisting of carbohydrates, citrate, fumarate, succinate, isocitrate, oxalacetate, realate, pyridoxyl-5-pyrophosphate, thiamine pyrophosphate, uridine-diphosphate-glucose, glucose-1-phosphate, adenosine and nicotinamide-adenine-diphosphate;
- at least one transfection active agent bound to said coated core particle wherein said transfection agent bound to said coated core particle is not denatured.
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| Background / Summary: |
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| Drawing Descriptions: |
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| Description: |
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| Forward References: |
Show 102 U.S. patent(s) that reference this one
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