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 Title: |
US5462750:
Biologically active compositions having a nanocrystalline core
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Kossovsky, Nir; Los Angeles, CA
Bunshah, Rointan F.; Playa del Rey, CA
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| Assignee: |
The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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| Published / Filed: |
1995-10-31
/ 1994-04-08
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| Application Number: |
US1994000225100
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| IPC Code: |
Advanced:
A61K 9/00;
A61K 9/51;
A61K 39/12;
A61K 47/26;
C07K 14/05;
Core:
C07K 14/005;
more...
IPC-7:
A61K 9/14;
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| ECLA Code: |
A61K9/00M5; A61K9/51; A61K47/26; C07K14/05;
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| U.S. Class: |
Current:
424/493;
424/204.1;
424/490;
424/494;
514/002;
514/770;
514/771;
514/772.3;
514/951;
514/970;
Original:
424/493;
424/204.1;
424/490;
424/494;
514/002;
514/770;
514/771;
514/772.3;
514/951;
514/970;
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| Field of Search: |
424/088,89,490,493,494,184.1,204.1
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| Priority Number: |
| 1994-04-08 |
US1994000225100 |
| 1993-01-06 |
US1993000000986 |
| 1990-06-22 |
US1990000542255 |
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| Abstract: |
A biologically active composition made up of core particles having diameters of less than about 1000 nanometers which are coated with a layer which is designed to allow attachment of biologically active proteins, peptides or pharmacological agents to the microparticles. When viral protein is attached to the core particles, the result is a viral decoy which accurately mimics the native virus in both size and structure while being entirely devoid of virulent activity due to the microparticle core. Other antigenic proteins or peptides are attached to provide molecules which are useful in raising antibodies or as a diagnostic tool. Further, pharmacological agents are attached to the microparticles to provide pharmaceutical compositions.
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| Attorney, Agent or Firm: |
Poms, Smith, Lande & Rose ;
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| Primary / Asst. Examiners: |
Page, Thurman K.; Spear, James M.
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| INPADOC Legal Status: |
None
Family Legal Status Report
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| Parent Case: |
This is a continuation of application Ser. No. 08/000,986, filed Jan. 6, 1993, now abandoned, which is a continuation of Ser. No. 07/542,255, filed on Jun. 22, 1990, U.S. Pat. No. 5,219,577.
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| Designated Country: |
BE CH FR GB GR IT LI LU NL SE
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| Family: |
Show 58 known family members
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First Claim:
Show all 9 claims |
What is claimed is:
1. A composition of matter which is made by a process comprising the steps of:
- providing a core particle having a diameter of less than about 1000 nanometers, said core particle comprising a metal, ceramic or polymer;
- depositing a coating of a sugar or oligonucleotide onto the surface of said core particle by the step of suspending said core particle in a solution which consists essentially of water and said sugar for a sufficient time to provide a coated core particle; and
- attaching a biologically active agent to said coated core particle wherein said biologically active agent includes at least one biologically active site and wherein said sugar or oligonucleotide which is deposited as said coating is selected to provide a threshold surface energy which is sufficient to bind said biologically active agent to said core particle without denaturing said biologically active site.
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| Background / Summary: |
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| Drawing Descriptions: |
Show drawing descriptions
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| Description: |
Show description
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| Forward References: |
Show 8 U.S. patent(s) that reference this one
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