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 Title: |
US5462751:
Biological and pharmaceutical agents having a nanomeric biodegradable core
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Kossovsky, Nir; Los Angeles, CA
Hnatyszyn, H. James; Los Angeles, CA
Gelman, Andrew; Los Angeles, CA
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| Assignee: |
The Regeants of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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| Published / Filed: |
1995-10-31
/ 1993-11-01
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| Application Number: |
US1993000146536
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| IPC Code: |
Advanced:
A61K 9/00;
A61K 9/127;
A61K 9/51;
A61K 38/28;
A61K 38/40;
A61K 38/42;
A61K 38/48;
A61K 39/12;
A61K 39/21;
A61K 47/26;
A61K 47/48;
A61K 48/00;
A61L 31/10;
C07K 14/05;
C07K 14/16;
C12N 11/14;
C12N 15/87;
A61K 38/00;
Core:
A61K 38/41;
A61K 38/43;
A61L 31/08;
C07K 14/005;
C12N 11/00;
more...
IPC-7:
A61K 9/14;
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| ECLA Code: |
A61K9/00M5F; A61K9/00M5; A61K9/127; A61K9/51; A61K38/28; A61K38/40; A61K38/42; A61K38/48; A61K39/21; A61K47/26; A61K47/48W14B; A61K48/00; A61L31/10; C07K14/05; C07K14/16; C12N11/14; C12N15/87;
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| U.S. Class: |
Current:
424/494;
424/093.6;
424/490;
424/493;
424/498;
514/002;
514/006;
514/951;
514/970;
Original:
424/494;
424/093.6;
424/490;
424/493;
424/498;
514/002;
514/006;
514/951;
514/970;
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| Field of Search: |
424/490,493,494,498
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| Priority Number: |
| 1993-11-01 |
US1993000146536 |
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| Abstract: |
A biologically active composition made up of biodegradable core particles which are coated with a layer that is designed to allow attachment of biologically active agents without denaturing them. The composition may further include an exterior targeting membrane which provides selective targeting to specific receptors.
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| Attorney, Agent or Firm: |
Poms, Smith, Lande & Rose ;
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| Primary / Asst. Examiners: |
Page, Thurman K.; Spear, James M.
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| INPADOC Legal Status: |
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| Parent Case: |
BACKGROUND OF THE INVENTION
This is a continuation-in-part of application Ser. No. 08/000,199 now U.S. Pat. No. 5,334,394 which was filed on Jan. 4, 1993 which is a continuation-in-part of Ser. No. 07/690,601, now U.S. Pat. No. 5,178,882 which was filed on Apr. 24, 1991 which is a continuation-in-part of application Ser. No. 07/542,255, now U.S. Pat. No. 5,219,577 which was filed on Jun. 22, 1990.
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| Designated Country: |
BB BG BR BY CZ FI HU KP KR KZ LK LV MG MN MW NO NZ OA PL RO BE CH FR GB GR IT LI LU MC NL
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| Family: |
Show 58 known family members
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First Claim:
Show all 8 claims |
What is claimed is:
1. A biochemically active composition of matter comprising:
- a biodegradable core particle comprising a polymer or ceramic having a diameter of less than about 1000 nanometers;
- a coating comprising a substance that provides a threshold surface energy to said core particle which is sufficient to bind biochemically active agents without denaturing said agents, said substance covering at least a part of the surface of said core particle and said substance being a carbohydrate; and
- at least one biochemically active agent bound to said coated core particle wherein said biologically active agent bound to said core particle is not denatured to thereby provide said biochemically active composition.
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| Background / Summary: |
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| Drawing Descriptions: |
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| Description: |
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| Forward References: |
Show 21 U.S. patent(s) that reference this one
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