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 Title: |
US5464634:
Red blood cell surrogate
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Kossovsky, Nir; Los Angeles, CA
Gelman, Andrew E.; Los Angeles, CA
Hnatyszyn, H. James; Los Angeles, CA
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| Assignee: |
The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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| Published / Filed: |
1995-11-07
/ 1994-04-25
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| Application Number: |
US1994000232756
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| IPC Code: |
Advanced:
A61K 9/00;
A61K 9/127;
A61K 9/18;
A61K 9/51;
A61K 38/42;
A61K 39/12;
A61K 39/21;
A61K 47/26;
A61L 31/10;
C07K 14/05;
Core:
A61K 38/41;
A61L 31/08;
C07K 14/005;
more...
IPC-7:
A61K 9/16;
A61K 9/18;
A61K 38/42;
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| ECLA Code: |
A61K9/00M5F; A61K9/00M5; A61K9/127; A61K9/51; A61K38/42; A61K39/21; A61K47/26; A61L31/10; C07K14/05;
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| U.S. Class: |
Current:
424/493;
424/450;
424/490;
424/491;
424/494;
424/498;
514/832;
Original:
424/493;
424/490;
424/491;
424/494;
424/498;
424/450;
514/832;
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| Field of Search: |
424/493,494,490,498,491,450
514/832
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| Priority Number: |
| 1994-04-25 |
US1994000232756 |
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| Abstract: |
A red blood cell surrogate which is composed of a nanocrystalline core particle to which an oxygen carrier such as hemoglobin is bound. An oxygen carrier anchor coating is provided between the nanocrystalline core particle and the oxygen carrier in order to provide binding of the oxygen carrier to the nanocrystalline core particle without denaturing the oxygen carrier or otherwise destroying its oxygen carrying capacity. The nanocrystalline core particle with the oxygen carrier bound thereto is coated with a layer of lipid and then an outer layer of a sugar or allosteric effector is applied.
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| Attorney, Agent or Firm: |
Poms, Smith, Lande & Rose ;
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| Primary / Asst. Examiners: |
Page, Thurman K.; Spear, James M.
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| INPADOC Legal Status: |
Show legal status actions
Family Legal Status Report
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| Parent Case: |
This is a continuation-in-part of application Ser. No. 08/029,773 which was filed on Mar. 3, 1993, now U.S. Pat. No. 5,306,508, which is a continuation-in-part of application Ser. No. 08/000,199 which was filed on Jan. 4, 1993, now U.S. Pat. No. 5,334,394, which is a continuation-in-part of application Ser. No. 07/690,601, now U.S. Pat. No. 5,178,882, which is a continuation-in-part of application Ser. No. 07/542,255, which was filed on Jun. 22, 1990, now U.S. Pat. No. 5,219,577.
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| Designated Country: |
AM AP BB BG BR BY CN CZ FI GE HU KE KG KP KR KZ LK LV MD MG MN MW BE CH FR GB GR IT LI LU MC
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| Family: |
Show 59 known family members
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First Claim:
Show all 29 claims |
What is claimed is:
1. A red cell surrogate comprising:
- a nanocrystalline core particle, said core particle having a surface;
- an oxygen carrier anchor coating located on the surface of said nanocrystalline core particle;
- an oxygen carrier bound to said oxygen carrier anchor coating;
- a layer of lipid surrounding said oxygen carrier; and
- an outer layer.
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| Background / Summary: |
Show background / summary
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| Drawing Descriptions: |
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| Description: |
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| Forward References: |
Show 9 U.S. patent(s) that reference this one
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| Foreign References: |
None
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| Other Abstract Info: |
CHEMABS 116(11)104322M
CHEMABS 124(06)066679P
CHEMABS 120(26)331094Q
CHEMABS 123(16)208983P
CHEMABS 124(01)007065N
CHEMABS 124(04)037703M
CHEMABS 124(06)066600F
CHEMABS 124(06)066679P
DERABS C1992-010276
DERABS C1994-134687
DERABS C1994-248851
DERABS C1994-248855
DERABS C1995-392797
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| Other References: |
Loo et al., "Alkaloid Formation in Ergot Sclerotia," Science, vol. 121, Mar. 1955, pp. 367-369.
Lewis, R. W., "Artificial Inoculation of Rye with Ergot. A Susceptible Rye and the Control of Ergot Beetles," J. Am. Pharm. Assoc., Dec. 1948, pp. 511-512.
von Recum, A. F., "Ceramics," Handbook of Biomaterials Evaluation, 1986, pp. 38-54.
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