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 Title: |
US5464823:
Mammalian antibiotic peptides
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Lehrer, Robert I.; Santa Monica, CA
Kokryakov, Vladimir N.; Los Angeles, CA
Harwig, Sylvia S. L.; Woodland Hills, CA
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| Assignee: |
The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
News, Profiles, Stocks and More about this company
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| Published / Filed: |
1995-11-07
/ 1993-07-26
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| Application Number: |
US1993000095769
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| IPC Code: |
Advanced:
A01N 63/02;
C07K 7/08;
C07K 16/18;
A61K 38/00;
Core:
C07K 7/00;
more...
IPC-7:
A61K 38/10;
C07K 7/00;
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| ECLA Code: |
A01N63/02; C07K7/08A; C07K16/18;
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| U.S. Class: |
Current:
514/013;
514/012;
530/324;
530/325;
530/326;
Original:
514/013;
514/012;
530/324;
530/325;
530/326;
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| Field of Search: |
530/326,325,324
514/013,12
536/23.5
435/69.1
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| Government Interest: |
This invention was made with funding from NIH Grant No. A122839. The U.S. Government has certain rights in this invention.
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| Priority Number: |
| 1993-07-26 |
US1993000095769 |
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| Abstract: |
Peptide-based compounds containing four invariant cysteine residues which have been oxidized to obtain two intramolecular disulfide bonds are useful as preservatives and in preventing, treating, or ameliorating viral or microbial infection in animals and plants. These compounds, in one embodiment, are of the formula:
A1 -A2 -A3 -A4 -A5 -C-A7 -C-A9 -A10 -A11 -A12 -C-A14 -C-A16 -(A17 -A18)(1) (SEQ ID NO:4)
and the N-terminal acylated, C-terminal amidated or esterified and the cystine-bridged forms thereof
- wherein A1, A9, A10 and A11 are basic amino acids;
- A2 and A3 are small amino acids;
- A5, A7, A12, A14 and A16 are hydrophobic amino acids; and
- A4 is a basic or a small amino acid;
- A17 is not present or, if present, is a small amino acid;
- A18 is not present or, if present, is a basic amino acid.
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| Attorney, Agent or Firm: |
Morrison & Foerster ;
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| Primary / Asst. Examiners: |
Furman, Keith C.;
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| Maintenance Status: |
CC Certificate of Correction issued
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| INPADOC Legal Status: |
Show legal status actions
Family Legal Status Report
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| Parent Case: |
This application is a continuation-in-part of U.S. Ser. No. 07/093,926 filed 20 Jul. 1993, the contents of which are incorporated herein by reference.
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| Designated Country: |
BB BG BR BY CA CN CZ FI HU KP KR KZ LK LV MG MN MW NO NZ OA PL BE CH FR GB GR IE IT LI LU MC NL
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| Family: |
Show 35 known family members
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First Claim:
Show all 18 claims |
We claim:
1. A purified and isolated compound having antimicrobial activity against E. coli, L. monocytogenes or Candida albicans, said compound being of the formula
A1 -A2 -A3 -A4 -A5 -C-A7 -C-A9 -A10 -A11 -A12 -C-A14 -C-A16 -(A17 -A18)(1) (SEQ ID NO:4)
and the N-terminal acylated, C-terminal amidated or esterified and the cystine-bridged forms thereof
- wherein A1, A9, A10 and A11 are basic amino acids;
- A2 and A3 are small amino acids;
- A5, A7, A12, A14 and A16 are hydrophobic amino acids; and
- A4 is a basic or a small amino acid;
- A17 is not present or, if present, is a small amino acid;
- A18 is not present or, if present, is a basic amino acid.
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| Background / Summary: |
Show background / summary
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| Drawing Descriptions: |
Show drawing descriptions
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| Description: |
Show description
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| Forward References: |
Show 46 U.S. patent(s) that reference this one
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| Foreign References: |
None
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| Other Abstract Info: |
CHEMABS 122(19)230760Q
CHEMABS 124(09)106630Z
CHEMABS 124(09)106630Z
CHEMABS 128(05)045808X
CHEMABS 128(11)127091X
CHEMABS 129(18)225713S
CHEMABS 132(01)002807M
DERABS C1995-075188
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| Other References: |
Kokryakar et al., Jul. 26, 1993, FEBS 327(2):231-236.
(6 pages)
Cited by 19 patents
[ISI abstract]
Robsen et al. 1986. Introduction to Protein Engineering, Elsevier, New York, p. 41.
Pongor, 1987, Methods in Enzymology 154:450-473.
(24 pages)
Cited by 25 patents
Nakamura et al., Tachyplesin, a Class of Antimicorbial Peptide from the Hemocytes of the Horseshoe Crab (Tachypleus tridentatus), J. Biol. Chem. (1988) 263:16709-16713.
(5 pages)
Cited by 28 patents
Miyata et al., Antimicrobial Peptides, Isolated from Horseshoe Crab Hemocytes, Tachyplesin II, and Polyphemusins I and II: Chemical Structures and Biological Activity, J. Biochem; (1989) 106:663-668.
(6 pages)
Cited by 18 patents
Murakami et al., Direct Virus Inactivation of Tachyplesin I and Its Isopeptides from Horseshoe Crab Hemocytes, Chemotherapy (1991) 37:327-334.
(8 pages)
Cited by 16 patents
[ISI abstract]
Morimoto et al., Inhibitory Effect of Tachyplesin I on the Proliferation of Human Immunodeficiency Virus in vitro, Chemotherapy (1991) 37:206-211.
(6 pages)
Cited by 14 patents
[ISI abstract]
Nakashima et al., Anti-Human Immunodeficiency Virus Activity of a Novel Synthetic Peptide, T22 ([Tyr-5,12,Lys-7]Polyphemusin II): a Possible Inhibitor of Virus-Cell Fusion, Antimicrobial Agents and Chemotherapy (1992) 1249-1255.
(7 pages)
Cited by 13 patents
[ISI abstract]
Lehrer et al., Defensins: Endogenous Antibiotic Peptides of Animal Cells, Cell (1991) 64:229-230.
(2 pages)
Cited by 32 patents
[ISI abstract]
Lehrer et al., Defensins: Antimicrobial and Cytotoxic Peptides of Mammalian Cells, Annual Review Immunol (1993) 11:105-128.
(24 pages)
Cited by 26 patents
[ISI abstract]
Selsted et al., Purification, Primary Structures, and Antibacterial Activities of β-Defensins, a New Family of Antimicrobial Peptides from Bovine Neutrophils, J. Biol Chem (1993) 288:6641-6648.
(8 pages)
Cited by 23 patents
[ISI abstract]
Diamond et al., Tracheal antimicrobial peptide, a cysteine-rich peptide from mammalian tracheal mucosa: Peptide isolation and cloning of a cDNA, Proc. Natl. Acad. Sci. (USA) (1991) 88:3952-3958.
(5 pages)
Cited by 26 patents
[ISI abstract]
Lambert et al., Insect Immunity: Isolation from immune blood of the dipteran Phormia terranovae of two insect antibacterial peptides with sequence homology to rabbit lung macrophage bactericidal peptides, Proc. Natl. Acad. Sci. (USA) (1989) 88:262-265.
(5 pages)
Cited by 11 patents
Broekaert et al., Antimicrobial Peptides from Amaranthus caudatus Seeds with Sequence Homology tothe Cysteine/Clycine-Rich Domain o Chitin-Binding Proteins, Biochemistry (1992) 31:4308-4314.
(7 pages)
Cited by 22 patents
[ISI abstract]
Cornelissen et al., Strategies for Control of Fungal Disease with Transgenic Plants, Plant Physiol (1993) 101:709-712.
(4 pages)
Cited by 22 patents
[ISI abstract]
Haln et al., Disease resistance results from foreign phytoalexin expression in a novel plant, Nature (1993) 361:153-156.
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| Continuity Data: |
| Application Number | Filed | Notes |
|---|
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US2003000627829 | 2003-07-24 | is a
continuation of |
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US2000000539443
| 2000-03-30 |
(abandoned)
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US2000000539443 | 2000-03-30 | is a
continuation of |
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US1998000128345
| 1998-08-03 |
(granted)
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US6159936 issued 2000-12-12 Compositions and methods for treating and preventing microbial and viral infections
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US1998000128345 | 1998-08-03 | is a
division of |
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US1995000499523
| 1995-07-07 |
(granted)
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US1998000128345 | 1998-08-03 | is a
continuation of |
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US1995000499523
| 1995-07-07 |
(granted)
|
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|
|
|
US1998000128345 | 1998-08-03 | is a
division of |
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US1995000451832
| 1995-05-26 |
(abandoned)
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|
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US1995000499523 | 1995-07-07 | is a
continuation in part of |
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US1995000451832
| 1995-05-26 |
(abandoned)
|
|
|
US1998000128345 | 1998-08-03 | is a
division of |
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US1994000243879
| 1994-05-17 |
(granted)
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US5708145 issued 1998-01-13 Immunglobulins reactive with protegrins
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|
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US1995000451832 | 1995-05-26 | is a
continuation in part of |
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US1994000243879
| 1994-05-17 |
(granted)
|
| |
US5708145 issued 1998-01-13 Immunglobulins reactive with protegrins
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|
|
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US1998000128345 | 1998-08-03 | is a
division of |
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US1994000182483
| 1994-01-13 |
(granted)
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US5693486 issued 1997-12-02 DNA sequences encoding protegrins and protegrin analogs and their use in recombinant methods of producing protegrins
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|
|
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US1994000243879 | 1994-05-17 | is a
continuation in part of |
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US1994000182483
| 1994-01-13 |
(granted)
|
| |
US5693486 issued 1997-12-02 DNA sequences encoding protegrins and protegrin analogs and their use in recombinant methods of producing protegrins
|
|
|
|
US1998000128345 | 1998-08-03 | is a
division of |
|
>US1993000095769<
| 1993-07-26 |
(granted)
|
| |
US5464823 issued 1995-11-07 Mammalian antibiotic peptides
|
|
|
|
US1994000182483 | 1994-01-13 | is a
continuation in part of |
|
>US1993000095769<
| 1993-07-26 |
(granted)
|
| |
US5464823 issued 1995-11-07 Mammalian antibiotic peptides
|
|
|
|
US1998000128345 | 1998-08-03 | is a
division of |
|
US1993000093926
| 1993-07-20 |
(abandoned)
|
|
|
>US1993000095769< | 1993-07-26 | is a
continuation in part of |
|
US1993000093926
| 1993-07-20 |
(abandoned)
|
|
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