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 Title: |
US5470824:
Method to treat Kaposi's sarcoma
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Miles, Steven A.; Sherman Oaks, CA
Stevens, Ronald H.; Marina Del Rey, CA
Martinez, Otoniel M.; Valencia, CA
Kishimoto, Tadamitsu; Osaka, Japan
Klashman, David J.; Sherman Oaks, CA
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| Assignee: |
The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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| Published / Filed: |
1995-11-28
/ 1991-05-31
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| Application Number: |
US1991000707863
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| IPC Code: |
Advanced:
C07K 14/16;
C07K 14/47;
C07K 14/52;
C07K 14/54;
C07K 14/715;
C07K 16/24;
C12P 21/08;
A61K 38/00;
Core:
C07K 14/005;
C07K 14/435;
C07K 16/18;
more...
IPC-7:
A61K 37/00;
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| ECLA Code: |
C07K14/16F; C07K14/47A1A; C07K14/52A1; C07K14/54B; C07K14/54D; C07K14/715; C07K16/24F6;
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| U.S. Class: |
Current:
514/002;
514/044.R;
530/351;
Original:
514/002;
514/044;
530/351;
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| Field of Search: |
514/044,2
536/027
530/351
435/240.2
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| Government Interest: |
This work was supported in part by grants from the State of California under the direction of the University-Wide Task Force on AIDS (R87LA039, R88LA078, R90LA121, R86LA012 and 89C-CC86LA), and by the National Institutes of Health (AI24691). The government has certain rights in this invention.
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| Priority Number: |
| 1991-05-31 |
US1991000707863 |
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| Abstract: |
Substances or agents which diminish the level of IL-6 or its activity in Kaposi's sarcoma-derived cells are useful agents in the treatment of Kaposi's sarcoma. In particular, substances which inhibit the expression of the gene encoding IL-6 or its receptor, or which interfere with the activity of these substances, are useful in the treatment of this condition. In particular, antibodies immunoreactive with these proteins, oligomers which interfere with the production of these materials, or substances which interfere with the activity of other proteins, DNAs or RNAs that regulate the production and activity of IL-6 are thus useful.
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| Attorney, Agent or Firm: |
Morrison & Foerster ;
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| Primary / Asst. Examiners: |
Chambers, Jasemine C.;
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| INPADOC Legal Status: |
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Family Legal Status Report
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| Designated Country: |
AU EP JP KR
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| Family: |
Show 3 known family members
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| Claim |
We claim:
1. A method to intervene in the progress of Kaposi's sarcoma, which method comprises administering to a subject in need of such intervention an amount of IL-4 effective to decrease IL-6 function in Kaposi's sarcoma-involved cells.
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| Background / Summary: |
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| Drawing Descriptions: |
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| Description: |
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| Forward References: |
Show 5 U.S. patent(s) that reference this one
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