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 Title: |
US5474547:
Implanting devices for the focal release of neuroinhibitory compounds
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Aebischer, Patrick; Barrington, RI
Tresco, Patrick A.; Wakefield, RI
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| Assignee: |
Brown University Research Foundation, Providence, RI
other patents from BROWN UNIVERSITY RESEARCH FOUNDATION (78215) (approx. 140)
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| Published / Filed: |
1995-12-12
/ 1993-12-16
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| Application Number: |
US1993000168858
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| IPC Code: |
Advanced:
A61F 2/02;
A61K 9/00;
A61K 9/22;
A61K 31/195;
A61M 31/00;
Core:
A61K 31/185;
more...
IPC-7:
A61K 9/22;
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| ECLA Code: |
A61F2/02B; A61K9/00M22; A61K31/195; A61M31/00D;
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| U.S. Class: |
Current:
604/891.1;
128/898;
128/899;
424/424;
Original:
604/891.1;
128/898;
128/899;
424/424;
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| Field of Search: |
604/049,890.1,891.1,27,28,93,56,43,116
623/011,12
424/422-424
128/897-899
435/041,180,182
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| Priority Number: |
| 1993-12-16 |
US1993000168858 |
| 1992-07-13 |
US1992000912463 |
| 1989-06-21 |
US1989000369296 |
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| Abstract: |
Methods are disclosed for the alleviation of movement disorders via the implantation of static devices which focally release neuroinhibitory compounds to preselected brain areas. Pathological conditions to be treated by these methods include parkinsonian movement disorders, Huntington's chorea, and epileptiform seizure activity. In the treatment of parkinsonism, target areas implantation include the subthalamic nucleus, the globus pallidus internus, and the substantia nigra pars reticulata. In the treatment of epilepsy, implants may be placed in an epileptogenic focus area of neural over-activity. The devices may be polymeric implants that release neuroinhibitory compounds such as GABA, GABA agonists, GABA potentiators, action potential blockers and voltage dependent calcium channel blockers, and glutamate antagonists. Alternatively, the devices may contain living cells which secrete neuroinhibitory compounds.
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| Attorney, Agent or Firm: |
Flehr, Hohbach, Test, Albritton & Herbert ;
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| Primary / Asst. Examiners: |
Rosenbaum, C. Fred; Alexander, V.
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| INPADOC Legal Status: |
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| Related Applications: |
| Application Number |
Filed |
Patent |
Pub. Date |
Title |
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| US1992000912463 | 1992-07-13 |
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| US1989000369296 | 1989-06-21 |
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| Parent Case: |
CROSS-REFERENCE TO RELATED APPLICATION
This application is a divisional of U.S. Ser. No. 07/912,463 filed Jul. 13, 1992, which is a continuation-in-part of U.S. Ser. No. 07/369,296, filed Jun. 21, 1989, now abandoned. U.S. Ser. No. 07/841,875 filed Feb. 26, 1992, now U.S. Pat. No. 5,156,844, is a continuation of Ser. No. 07/369,296, which is a continuation-in-part of U.S. Ser. No. 07/121,626, filed Nov. 17, 1987, now U.S. Pat. No. 4,892,538.
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| Designated Country: |
BE CH DK FR GB GR IE IT LI LU MC NL PT SE KR
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| Family: |
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First Claim:
Show all 9 claims |
What is claimed is:
1. A method for alleviating parkinsonian movement disorders in an individual having the same, comprising
- implanting a static device adjacent a brain area within the basal ganglia of said individual, said brain area selected from the group consisting of the subthalamic nucleus, globus pallidus internus, and substantia nigra pars reticulata,
- said device focally releasing at least one compound which acts to inhibit over-activity in at least one neuron within said brain area,
- said compound being selected from the group consisting of GABA, GABA agonists, GABA potentiators, action potential blockers, voltage dependent calcium channel blockers, glutamate antagonists, phenytoin, carbamezepine, valproate, barbiturates, benzodiazapines, ethosuximide, tetrodotoxin, saxitoxin, and conotoxins,
- said inhibition effecting the disruption of neural over-activity within said basal ganglia,
- said disruption effecting the alleviation of said parkinsonian movement disorders.
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| Background / Summary: |
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| Drawing Descriptions: |
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| Description: |
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| Forward References: |
Show 51 U.S. patent(s) that reference this one
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