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Title: US5475086: Cloned glutamic acid decarboxylase peptides
[ Derwent Title ]

Country: US United States of America

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22 pages

 
Inventor: Tobin, Allan J.; Los Angeles, CA
Erlander, Mark G.; Tarzana, CA
Kaufman, Daniel L.; Santa Monica, CA
Clare-Salzler, Michael J.; Los Angeles, CA

Assignee: The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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Published / Filed: 1995-12-12 / 1993-10-13

Application Number: US1993000135849
IPC Code: Advanced: C12N 9/88; G01N 33/564; A61K 38/00; A61K 39/00;
Core: more...
IPC-7: C07K 7/04; C07K 14/00; C12N 9/88;

ECLA Code: C12N9/88; G01N33/564; K61K38/00; K61K39/00; M12N203/00; M12N207/00; M12N215/00; M12Q220/114F35; M12Q220/120; S01N800/04A; S01N800/24;

U.S. Class: Current: 530/325; 435/232; 530/326; 530/327; 530/328; 530/329;
Original: 530/325; 530/326; 530/327; 530/328; 530/329; 435/232;

Field of Search: 435/232 530/324-329,403 930/240

Government Interest:     The present invention was supported by Grant NS22256 from the National Institutes of Health. The United States Government has certain rights in this invention.

Priority Number:
1993-10-13  US1993000135849
1991-06-18  US1991000716909
1990-09-21  US1990000586536

Abstract:     Isolated polypeptides useful in ameliorating autoimmune disease.

Attorney, Agent or Firm: Rowland, Bertram I. ;

Primary / Asst. Examiners: Wax, Robert A.; Hendricks, Keith D.
INPADOC Legal Status: None          Buy Now: Family Legal Status Report

       
Related Applications: Go to Result Set: 1 patent(s) that list this one as related
Application Number Filed Patent Pub. Date  Title
US1991000716909 1991-06-18       
US1990000586536 1990-09-21       


       
Parent Case:     This is a continuation of application Ser. No. 07/716,909 filed on Jun. 18, 1991, now abandoned, which is a continuation-in-part of U.S. Ser. No. 07/586,536, filed Sep. 21, 1990, now abandoned.

Designated Country: BE CH FR GB IT LI LU MC NL PT SE  NO 

Family: Show 67 known family members
First Claim:
Show all 3 claims		 We claim:     1. An isolated polypeptide consisting of the following amino acid sequence:
    X-Pro-Glu-Val-Lys-Y-Lys-Z
  • wherein X is an amino acid sequence selected from one to ten amino acids or omitted; Y is Glu, and Z is an amino acid sequence selected from one to eight amino acids or omitted,
  • wherein the polypeptide is derived from human GAD65 and stimulates in vitro proliferation of human T lymphocytes.
    •


Background / Summary: Show background / summary

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Description: Show description

Forward References: Show 8 U.S. patent(s) that reference this one

       
U.S. References: Go to Result Set: All U.S. references   |  Forward references (8)   |   Backward references (0)   |   Citation Link

       
Foreign References: None

Other Abstract Info: CHEMABS 117(23)227775Q CHEMABS 118(23)225673B CHEMABS 127(23)315578Q DERABS C1992-150489 DERABS C1992-425701 DERABS C2000-095930 DERABS C2000-500251

Other References:
  • Gerling, et al. Effect of Coxsackievirus B4 Infection in Mice on Expression of 64,000-Mr Autoantigen and Glucose Sensitivity of Islets Before Development of Hyperglycemia, Oct. 1988, pp. 1419-1425. (7 pages) Cited by 6 patents
  • Dryberg, T. Molecolar Mimicry and Diabetes, 1989, pp. 117-125.
  • Schwimmbeck, et al. Molecular Mimicry and Myasthenia Gravis, Oct. 1989, pp. 1174-1180. (7 pages) Cited by 7 patents
  • Todd, et al. A Molecular Basis For Genetic Susceptibility to insulin-Dependent Diabetes Mellitus, May, 1988, pp. 129-134. (6 pages) Cited by 7 patents
  • Wraith, et al. Antigen Recognition in Autoimmune Encephalomyelitis and the Potential for Peptide-Mediated Immunotherapy, Oct. 1989, pp. 247-255. (9 pages) Cited by 56 patents
  • Chang et al. J. Neurosci., 8(6):2123-2130, Jun. 1988. (8 pages) Cited by 14 patents
  • Julien et al. J. Neurochem., 54(2): 703-705, 1990. (3 pages) Cited by 16 patents
  • Julien et al. Neurosci. Lett., vol. 73, pp. 173-180, 1987. (8 pages) Cited by 9 patents
  • Baekkeskov et al., Diabetes, vol. 38, pp. 1133-1141, Sep. 1989. (9 pages) Cited by 9 patents
  • Legay et al., J. Neurochem., 48(4): 1022-1026, 1987. (5 pages) Cited by 9 patents
  • Geysen et al., PNAS, vol. 81, pp. 3998-4002, Jul. 1984.


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