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 Title: |
US5500343:
Allelic association of the human dopamine(D2) receptor gene in compulsive disorders
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Blum, Kenneth; San Antonio, TX
Noble, E. P.; Los Angeles, CA
Sheridan, P. J.; San Antonio, TX
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| Assignee: |
Board of Regents, The University of Texas System, Austin, TX
Regents of the University of California, Berkeley, CA
other patents from UNIVERSITY OF TEXAS (600015) (approx. 1,442)
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| Published / Filed: |
1996-03-19
/ 1992-06-24
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| Application Number: |
US1992000909383
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| IPC Code: |
Advanced:
C12Q 1/68;
Core:
more...
IPC-7:
C07H 21/04;
C12N 15/00;
C12P 19/34;
C12Q 1/68;
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| ECLA Code: |
C12Q1/68M; C12Q1/68M6;
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| U.S. Class: |
Current:
435/006;
435/091.1;
435/091.2;
435/810;
536/023.1;
536/023.5;
536/024.33;
Original:
435/006;
435/091.1;
435/091.2;
435/810;
536/023.1;
536/023.5;
536/024.33;
935/031;
935/078;
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| Field of Search: |
435/006,91,975,91.1,91.2,810
536/23.1,23.5,24.31,24.33
935/078,31
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| Government Interest: |
The United States government has certain rights in the present invention because research relating to its development was partially supported by funds from NIDA, DA 04268 and DA 0146.
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| Priority Number: |
| 1992-06-24 |
US1992000909383 |
| 1992-01-23 |
US1992000826222 |
| 1990-02-07 |
US1990000477057 |
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| Abstract: |
In an important embodiment, the present invention concerns a method for detecting compulsive disorder susceptibility of a human. The method comprises initially obtaining a DNA sample of said human and then determining the presence or absence of a particular human D2 receptor gene allele in said sample. Detection of said allele in the sample is indicative of susceptibility to compulsive disorder. A most preferred embodiment is to detect a susceptibility to alcoholism and cocaine dependence, particularly because said allele has been found to be present in a majority of clinically diagnosed alcoholics and cocaine users. The human D2 receptor gene A1 and B1 alleles are most preferably detected in said sample.
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| Attorney, Agent or Firm: |
Arnold, White & Durkee ;
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| Primary / Asst. Examiners: |
Jones, W. Gary; Sisson, Bradley L.
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| INPADOC Legal Status: |
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Family Legal Status Report
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| Parent Case: |
This application is a continuation-in-part of applications PCT/US91/00855, filed Feb. 7, 1991, and Ser. No. 07/826,222, filed Jan. 23, 1992, now U.S. Pat. No. 5,210,016, which is a continuation of Ser. No. 07/477,057, filed Feb. 7, 1990; the contents of all of which are incorporated by reference herein.
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| Designated Country: |
BE CH DE DK ES FR GB GR IT LI LU NL SE
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| Family: |
Show 15 known family members
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First Claim:
Show all 10 claims |
What is claimed:
1. A method of detecting a genetic potential susceptibility to cocaine dependence in a human subject, comprising:
- isolating DNA from said subject; and
- detecting, in said DNA, a human dopamine D2 receptor gene A1 or B1 allele indicating
- a potential susceptibility to cocaine dependence.
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| Background / Summary: |
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| Drawing Descriptions: |
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| Description: |
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| Forward References: |
Show 6 U.S. patent(s) that reference this one
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