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 Title: |
US5527882:
Polypeptide having an amino acid replaced with N-benzylglycine
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Mitchell, Alexander R.; Livermore, CA
Young, Janis D.; Los Angeles, CA
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| Assignee: |
The Regents of the University of California, Alameda, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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| Published / Filed: |
1996-06-18
/ 1994-11-07
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| Application Number: |
US1994000335202
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| IPC Code: |
Advanced:
C07K 7/14;
C07K 7/16;
C07K 7/18;
C07K 7/23;
C07K 7/64;
C07K 14/575;
C07K 14/595;
Core:
C07K 7/00;
C07K 14/435;
IPC-7:
A61K 38/00;
C07K 7/00;
C07K 7/06;
C07K 7/18;
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| ECLA Code: |
C07K7/14; C07K7/16; C07K7/18; C07K7/23; C07K7/64; C07K14/575L; C07K14/595;
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| U.S. Class: |
Current:
530/328;
530/313;
530/329;
Original:
530/328;
530/313;
530/329;
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| Field of Search: |
514/016
530/328,314,329
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| Priority Number: |
| 1994-11-07 |
US1994000335202 |
| 1992-09-16 |
US1992000945664 |
| 1989-07-07 |
US1989000376839 |
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| Abstract: |
The present invention relates to one or more polypeptides having useful biological activity in a mammal, which comprise:
a polypeptide related to bradykinin of four to ten amino acid residues wherein one or more specific amino acids in the polypeptide chain are replaced with achiral N-benzylglycine. These polypeptide analogues have useful potent agonist or antagonist pharmacological properties depending upon the structure. A preferred polypeptide is (N-benzylglycine7)-bradykinin.
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| Attorney, Agent or Firm: |
Phillips, Moore, Lempio & Finley ;
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| Primary / Asst. Examiners: |
Warden, Jill; Marshall, S. G.
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| Maintenance Status: |
E2 Expired Check current status
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| INPADOC Legal Status: |
Show legal status actions
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| Related Applications: |
| Application Number |
Filed |
Patent |
Pub. Date |
Title |
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| US1992000945664 | 1992-09-16 |
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| US1989000376839 | 1989-07-07 |
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| Parent Case: |
This is a continuation of copending application of Ser. No. 07/945,664 filed on Sep. 16, 1992, now abandoned, which is a divisional of application Ser. No. 07/376,839, filed on Jul. 7, 1989, now abandoned.
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| Family: |
None
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First Claim:
Show all 15 claims |
We claim:
1. A polypeptide wherein the amino acid sequence is an analog of:
- bradykinin having the structure,
- [Arg-Pro-Pro-Gly-Phe- Ser-Pro-Phe-Gly,]
- Arg-Pro-Pro-Gly-Phe- Ser-Pro-Phe-Arg,
- wherein the amino acid designated * indicates a replacement of one, two or three starred (*) amino acids with N-benzylglycine.
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| Background / Summary: |
Show background / summary
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| Drawing Descriptions: |
Show drawing descriptions
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| Description: |
Show description
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| Forward References: |
Show 3 U.S. patent(s) that reference this one
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| Foreign References: |
None
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| Other Abstract Info: |
CHEMABS 125(11)143337A
CAN125(11)143337A
DERABS C96-299898
DERC96-299898
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| Other References: |
Dunn et al, J. of Medicinal Chemistry, vol. 14, No. 9, pp. 779-781.
R. J. Vavrek, et al. (1985), "Competitive Antagonists of Bradykinin," Peptides, vol. 6, pp. 161-164.
(4 pages)
Cited by 3 patents
J. M. Stewart, et al., (1984), Solid Phase Peptide Synthesis, published by Pierce Chemical Compay, Rockford, Illinois, Table of Contents.
K. McKean, "Pain," Discover magazine, (Oct. 1986), pp. 82-92.
H. O. J. Collier, "Kinins," Scientific American, Aug. 1962, 207, pp. 111-118.
C. V. Greco (1962), "Synthesis of Sydnones and Sydnone Iminies," J. Medicinal Chemistry, vol. 5, pp. 861-865.
J. D. Young, et al (1989), "Use of N-Benzylglycine as a Replacement for Aromatic Amino Acid Residues, Synthesis of (N-Benzylglycine Bradykinin," paper in the Proceedings of the 11th Amer. Peptide Symp., Salk Institute, UCSD, La Jolla, CA, Jul. 9-14, 1989.
J. J. Nestor, Jr., et al. (1988), "Luteinizing Hormone Releasing Hormone Analogs in Control of Fertility and Gonadal Hormone Dependent Disease," Annual Reports in Medical Chemistry, vol. 23, R. C. Allen (ed.) Academic Press, New York, NY, pp. 211-221.
(10 pages)
M. Freifelder (1963), "Hydrogenation of Some Pyridinealkanoic Acids," J. of Organic Chemistry, vol. 28, pp. 602-603.
M. Freifelder (1963), "Hydrogenation of Pyridines and Quinolines," Advances in Catalysts and Related Subjects, vol. 28, pp. 602-603.
"A Skita (1915) Urbger die Reduktion von aromatischen Alkoholen, Aldehyden und Ketonen," Ber, 48, pp. 1685-1698.
L. R. Steranka (1989), "Antogonists of B2 bradykinin receptors," The FASEB Journal, vol. 3, pp. 2019-2025.
(7 pages)
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