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Title: US5580772: Association between a novel human intracisternal A-type retroviral particle-type II (HIAP-II) and idiopathic CD4+ T-lymphocytopenia (ICL)
[ Derwent Title ]


Country: US United States of America

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14 pages

 
Inventor: Garry, Jr., Robert F.; New Orleans, LA

Assignee: The Administrattors of the Tulane Educational Fund, New Orleans, LA
other patents from TULANE EDUCATIONAL FUND (590595) (approx. 84)
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Published / Filed: 1996-12-03 / 1994-05-17

Application Number: US1994000245385

IPC Code: Advanced: C12N 7/00; G01N 33/569;
IPC-7: A61K 39/21; C12N 7/00; C12N 7/02;

ECLA Code: C12N7/00; G01N33/569K2; M12N740/10021;

U.S. Class: Current: 435/235.1; 424/207.1; 435/005; 435/239;
Original: 435/235.1; 435/005; 435/239; 424/207.1;

Field of Search: 435/235.1,239,5 424/207.1,208.1

Priority Number:
1994-05-17  US1994000245385

Abstract:     The present invention relates to the discovery of a novel retroviral particle associated with idiopathic CD4+ T-lymphocytopenia (ICL). New methods of diagnosis and treatment of ICL, novel cell lines comprising the new retrovirus, assay systems that may be used in the development of antiretroviral pharmaceuticals, model systems for the study of ICL and other immune diseases including acquired immunodeficiency syndrome (AIDS), and a diagnostic kit are provided by the present invention.

Attorney, Agent or Firm: Pennie & Edmonds ;

Primary / Asst. Examiners: Mosher, Mary E.;

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Designated Country: AM AP BB BG BR BY CA CN CZ EE EP FI GE HU IS JP KE KG KR KZ LK LR LT LV MD MG MN MW MX NO NZ OA PL RO RU SD SG SI SK 

Family: Show 3 known family members

First Claim:
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What is claimed:     1. A substantially purified human retrovirus associated with idiopathic CD4+ T-lymphocytopenia, having an icosahedral shape, smooth external surface, and a size of about 60 nm, prepared by a method comprising:
  • (a) obtaining cells taken from a person suffering from idiopathic CD4+ T-lymphocytopenia;
  • (b) adding the cells obtained in step (a), or an extract obtained therefrom, to a culture of RH9 cells having ATCC accession number CRL 12043;
  • (c) culturing the RH9 cells with the cells obtained in step (a), or with the extract obtained therefrom, according to step (b);
  • (d) lysing the cells of step (c) and preparing a microsomal fraction therefrom;
  • (e) treating the microsomal fraction with detergent;
  • (f) layering the detergent-treated microsomal fraction over a 48% (w/v) sucrose cushion;
  • (g) centrifuging the microsomal fraction layered over the sucrose cushion at about 60,000 g for about 30 min to form pelletted material;
  • (h) layering the pelletted material on a 33-68% (w/v) sucrose gradient;
  • (i) centrifuging the sucrose gradient at about 100,000 g for about 12 hours; and
  • (j) collecting fractions corresponding to a density of about 1.2 g/cm3.


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Patent  Pub.Date  Inventor Assignee   Title
Get PDF - 11pp US5344774  1994-09 Garry, Jr. et al.  The Administrators of the Tulane Educational Fund Human intracisternal A-type retroviral particles associated with sjogren's syndrome
Get PDF - 16pp US5364757  1994-11 Garry, Jr. et al.  Administrators of the Tulane Educational Fund Methods of supporting a diagnosis of systemic lupus erythematosus
       
Foreign References:
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PDF
Publication Date IPC Code Assignee   Title
Get PDF - 33pp WO9118089 1991-11  C12N 7/00 ALEXANDER STEVE S JR ASSOCIATION BETWEEN A HUMAN IMMUNODEFICIENCY VIRUS-RELATED RETROVIRUS AND SJOGREN'S SYNDROME 
Get PDF - 53pp WO9312221 1993-06  C12N 7/02 ALEXANDER, Steve, Stanley, Jr. ASSOCIATION BETWEEN A HUMAN IMMUNODEFICIENCY VIRUS-RELATED RETROVIRUS AND AUTOIMMUNE DISEASE 


Other Abstract Info: CHEMABS 124(09)115470Z DERABS C96-010918

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