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Title: US5587454: Omega conopeptide compositions
[ Derwent Title ]


Country: US United States of America

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59 pages

 
Inventor: Justice, Alan; Sunnyvale, CA
Singh, Tejinder; Palo Alto, CA
Gohil, Kishor C.; Richmond, CA
Valentino, Karen L.; San Carlos, CA
Miljanich, George P.; Redwood City, CA

Assignee: Neurex Corporation, Menlo Park, CA
other patents from NEUREX CORPORATION (397535) (approx. 15)
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Published / Filed: 1996-12-24 / 1993-04-15

Application Number: US1993000049794

IPC Code: Advanced: A61K 38/17; C07K 14/435; G01N 33/94; A61K 38/00;
Core: more...
IPC-7: A61K 38/00; C07K 5/00; C07K 7/00; C07K 17/00;

ECLA Code: A61K38/17; C07K14/435; G01N33/94P;

U.S. Class: Current: 530/324; 530/300;
Original: 530/324; 530/300;

Field of Search: 514/012 530/300,324

Priority Number:
1993-04-15  US1993000049794
1991-12-30  US1991000814759

Abstract: Disclosed are novel omega conotoxin peptides effective in producing analgesia.

Attorney, Agent or Firm: Stratford, Carol A. ; Dehlinger, Peter J. ;

Primary / Asst. Examiners: Davenport, Avis M.;

Maintenance Status: CC Certificate of Correction issued

INPADOC Legal Status: Show legal status actions          Buy Now: Family Legal Status Report

       
Related Applications: Go to Result Set: 5 patent(s) that list this one as related
Application Number Filed Patent Pub. Date  Title
US1991000814759 1991-12-30       


       
Parent Case:     This application is a continuation in part of U.S. application Ser. No. 07/814,759 filed on Dec. 30, 1991 now abandoned and claims priority to PCT application PCT/US92/11349.

Designated Country: BE CH DK ES FR GB GR IE IT LI LU MC NL PT SE  CA HU JP KR NO RU 

Family: Show 18 known family members

First Claim:
Show all 3 claims
It is claimed:     1. An omega conopeptide having the sequence: SEQ ID NO: 30 (SNX-236).

Background / Summary: Show background / summary

Drawing Descriptions: Show drawing descriptions

Description: Show description

Forward References: Show 14 U.S. patent(s) that reference this one

       
U.S. References: Go to Result Set: All U.S. references   |  Forward references (14)   |   Backward references (0)   |   Citation Link

       
Foreign References:
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Publication Date IPC Code Assignee   Title
Buy PDF- 75pp WO9107980 1991-06  A61K 37/02 NEUREX CORPORATION COMPOSITIONS FOR TREATING ISCHEMIA-RELATED NEURONAL DAMAGE 


Other Abstract Info: CHEMABS 119(17)174221P CHEMABS 126(11)139894H CHEMABS 126(11)139894H DERABS C1993-227270 DERABS C1998-582596 DERABS C1999-120002 DERABS C2000-038270 DERABS C2000-490177 DERABS C2001-030946

Other References:
  • Basilico, L., et al., "Influence of ω-conotoxin on morphine analgesia and withdrawal syndrome in rats," European Journal of Pharmacology 218(1):75-81 (1992). (7 pages) Cited by 7 patents [ISI abstract]
  • Basilico, L., et al., "Interaction of Opiates with ω-Conotoxin in Guinea Pig Ileum In Vitro," Pharmacological Research 21(1):65 (1989).
  • Benedek, G., and M. Sziksza, "Potentiation of thermoregulatory and anagesic effects of morphine by calcium antagonists," Pharmacological Research Communications 16(10):1009 (1984). (10 pages) Cited by 6 patents
  • Ben-Sreti, M. M., et al., "Effects of elevated calcium and calcium antagonists on 6,7-benzomorphan-induced analgesia," European Journal of Pharmacology 90:385-391 (1983). (7 pages) Cited by 2 patents
  • Carta, F., et al., "Effect of Nifedipine on Morphine-Induced Analgesia," Chemical Abstracts 114(19):abstract No. 178244t.
  • Contreras, E., et al., "Calcium channel antagonists increase morphine-induced analgesia and antagonize morphine tolerance," European Journal of Pharmacology 148:463-466 (1988). (4 pages) Cited by 5 patents
  • Del Pozo, E., et al., "Analgesic effects of several calcium channel blockers in mice," European Journal of Pharmacology 137:155-160 (1987).
  • Feldman, D. H., et al., "Omega Conus geographus toxin: a peptide that blocks calcium channels," FEBS Letters 214(2):295-300 (1987). (6 pages) Cited by 4 patents
  • Hoffmeister, F., and D. Tettenborn, "Calcium agonists and antagonists of the dihydropyridine type: Antinociceptive effects, interference with opiate-µ-receptor agonists and neuropharmacological actions in rodents," Psychopharmacology 90:299-307 (1986). (9 pages) Cited by 4 patents
  • Kavaliers, M., "Stimulatory influences of calcium channel antagonists on stress-induced opioid analgesia and locomotor activity," Brain Research 408:403-407 (1987). (5 pages) Cited by 3 patents
  • Konno, F., and I. Takayanagi, "Relationship between synaptosomal calcium uptake and antinociceptive action of morphine," Japan. J. Pharmacol. 33:619-626 (1983). (8 pages) Cited by 4 patents
  • Lux, F., et al., "Interaction of Morphine with Intrathecally Administered Calcium and Calcium Antagonists: Evidence for Supraspinal Endogenous Opioid Mediation of Intrathecal Calcium-Induced Antinociception in Mice," J. Pharmacol. Exp. Therapeutics 246:500 (1988). (8 pages) Cited by 4 patents
  • Mackie, K., and B. Hille, "Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells," Proc. Natl. Acad. Sci. USA 89:3825-3829 (1992). (5 pages) Cited by 4 patents [ISI abstract]
  • Antkiewicz-Michaluk et al., "Role of calcium channels in effects of antidepressant drugs in responsiveness to pain," Chemical Abstracts 115(21):abstract No. 223387a.
  • Ocana, M., and J. M. Baeyens, "Analgesic effects of centrally administered aminoglycoside antibiotics in mice," Neuroscience Letters 126:67-70 (1991). (4 pages) Cited by 3 patents [ISI abstract]
  • Olivera, B. M., et al., "Neuronal Calcium Channel Antagonists. Discrimination between Calcium Channel Subtypes Using ω-Conotoxin from Conus Magus venom," Biochemistry 26:2086-2090 (1987). (5 pages) Cited by 19 patents
  • Prado, W. A., et al., "Antinociception induced by intraperitoneal injection of gentamicin in rats and mice," Pain 41:365-371 (1990). (7 pages) Cited by 3 patents
  • Welch, S. P., and W. L. Dewey, "A Characterization of the Antinociception Produced by Intracerebroventricular Injection of 8-(N,N-Diethylamino)Octyl-3,4,5,-Trimethoxybenzoate in Mice," J. Pharmacol. Exp. Therapeutics 239:320 (1986). (7 pages) Cited by 4 patents
  • Woodward, J. J., et al., "Differential sensitivity of synaptosomal calcium entry and endogenous dopamine release to ω-conotoxin," Brain Research 475:141-145 (1988). (5 pages) Cited by 4 patents
  • Knaus, H-G., et al., "Neurotoxic aminoglycoside antibiotics are potent inhibitors [125 I]-Omega-Conotoxin GVIA binding to guinea-pig cerebral cortex membranes," Naunyn-Schmiedeberg's Arch Pharmacol 336: 583-586 (1987). (4 pages) Cited by 3 patents
  • Wagner, J. A., et al., "Aminoglycoside effects on voltage-sensitive calcium channels and neurotoxicity," New England J. Medicine 317(26): 1669 (1987). (1 pages) Cited by 3 patents


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