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 Title: |
US5595972:
Conotoxin peptides
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Olivera, Baldomero M.; Salt Lake City, UT
Cruz, Lourdes J.; Salt Lake City, UT
Hillyard, David R.; Salt Lake City, UT
McIntosh, J. Michael; Salt Lake City, UT
Santos, Ameurfino D.; Quezon City, Philippines
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| Assignee: |
University of Utah Research Foundation, Salt Lake City, UT
other patents from UNIVERSITY OF UTAH RESEARCH FOUNDATION (600050) (approx. 286)
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| Published / Filed: |
1997-01-21
/ 1995-06-07
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| Application Number: |
US1995000487174
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| IPC Code: |
Advanced:
C07K 14/435;
A61K 38/00;
A61K 39/00;
Core:
more...
IPC-7:
A61K 38/10;
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| ECLA Code: |
C07K14/435;
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| U.S. Class: |
Current:
514/013;
435/007.23;
436/064;
436/813;
514/003;
514/012;
Original:
514/013;
514/003;
514/012;
435/007.23;
436/064;
436/813;
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| Field of Search: |
530/300,324,326
514/002,13,14
435/7.23
436/064,813
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| Government Interest: |
This invention was made with Government support under Grant No. GM-22737 awarded by the National Institutes of Health, Bethesda, Md. The United States Government has certain rights in the invention.
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| Priority Number: |
| 1995-06-07 |
US1995000487174 |
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| Abstract: |
The invention is directed to A-lineage conotoxin peptides, which are conotoxin peptides that have strong homology in the signal sequence and the 3'-untranslated region of the genes coding for these peptides to the sequences in the α-conotoxin peptides. The A-lineage conotoxin peptides include the α-conotoxin peptides, the α-conotoxin-like peptides and the .kappa.-conotoxin peptides, described further below. The α-conotoxin-peptides generally share a "core" sequence motif. This core sequence is termed the α3/5 core and is represented as Cys-Cys-Xaa-Xaa-Xaa-Cys-Xaa-Xaa-Xaa-Xaa-Xaa-Cys (SEQ ID NO: 1). The α-conotoxin-like peptides generally share a core sequence termed the α4/7 core and is represented as Cys-Cys-Xaa-Xaa-Xaa-Xaa-Cys-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Cys (SEQ ID NO:2). The .kappa.-conotoxin peptides generally have a core sequence termed the .kappa.7/2/1/3 core and is represented as Cys-Cys-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Cys-Xaa-Xaa-Cys-Xaa-Cys-Xaa-Xaa-Xaa-Cys (SEQ ID NO:3) α-conotoxins MII (SEQ ID NO:54) and U002 (SEQ ID NO:10) preferentially bind to neuronal nicotinic acetylcholine receptors, rather than neuromuscular receptors. These latter two conotoxins can be used to diagnose and treat small-cell lung carcinomas, which have cholinergic nicotinic receptors.
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| Attorney, Agent or Firm: |
Venable, Baetjer, Howard & Civiletti ;
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| Primary / Asst. Examiners: |
Wax, Robert A.; Bugaisky, Gabriele E.
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| INPADOC Legal Status: |
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| Parent Case: |
CROSS REFERENCE TO RELATED APPLICATION
This application is a continuation-in-part of application Ser. No. 08/137,800, filed Oct. 19, 1993, now U.S. Pat. No. 5,514,774 which in turn is a continuation-in-part of application Ser. No. 08/084,848, filed Jun. 29, 1993, now U.S. Pat. No. 5,432,155 both of which are incorporated herein by reference.
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| Designated Country: |
BE CH FR GB GR IE IT LI LU MC NL SE FI KR
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| Family: |
Show 51 known family members
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First Claim:
Show all 4 claims |
What is claimed is:
1. A method for treating a patient having SCLC by administration of an α-conotoxin selected from the group consisting of MII (SEQ ID NO: 54) and U002(SEQ ID NO: 10).
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| Background / Summary: |
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| Drawing Descriptions: |
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| Description: |
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| Forward References: |
Show 8 U.S. patent(s) that reference this one
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