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 Title: |
US5633347:
Conotoxin peptides
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Olivera, Baldomero M.; Salt Lake City, UT
Cruz, Lourdes J.; Salt Lake City, UT
Hillyard, David R.; Salt Lake City, UT
McIntosh, J. Michael; Salt Lake City, UT
Santos, Ameurfino O.; Quezon City, Philippines
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| Assignee: |
University of Utah Research Foundation, Salt Lake City, UT
other patents from UNIVERSITY OF UTAH RESEARCH FOUNDATION (600050) (approx. 286)
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| Published / Filed: |
1997-05-27
/ 1995-06-07
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| Application Number: |
US1995000480750
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| IPC Code: |
Advanced:
C07K 14/435;
A61K 38/00;
A61K 39/00;
Core:
more...
IPC-7:
C07K 14/435;
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| ECLA Code: |
C07K14/435A;
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| U.S. Class: |
Current:
530/324;
530/300;
530/857;
Original:
530/324;
530/300;
530/857;
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| Field of Search: |
530/300,324,326,325
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| Government Interest: |
This invention was made with Government support under Grant No. GM-22737 awarded by the National Institutes of Health, Bethesda, Md. The United States Government has certain rights in the invention.
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| Priority Number: |
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| Abstract: |
The invention is directed to A-lineage conotoxin peptides, which are conotoxin peptides that have strong homology in the signal sequence and the 3'-untranslated region of the genes coding for these peptides to the sequences in the α-conotoxin peptides. The A-lineage conotoxin peptides include the α-conotoxin peptides, the α-conotoxin-like peptides and the .kappa.-conotoxin peptides, described further below. The α-conotoxin-peptides generally share a "core" sequence motif. This core sequence is termed the α3/5 core and is represented as Cys-Cys-Xaa-Xaa-Xaa- Cys-Xaa-Xaa-Xaa-Xaa-Xaa-Cys (SEQ ID NO:1). The α-conotoxin-like peptides generally share a core sequence termed the α4/7 core and is represented as Cys-Cys-Xaa-Xaa-Xaa-Xaa-Cys-Xaa- Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Cys (SEQ ID NO:2). The .kappa.-conotoxin peptides generally have a core sequence termed the .kappa.7/2/1/3 core and is represented as Cys-Cys-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa- Xaa-Cys-Xaa-Xaa-Cys-Xaa-Cys-Xaa-Xaa-Xaa-Cys (SEQ ID NO:3).
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| Attorney, Agent or Firm: |
Venable, Baetjer, Howard & Civiletti, LLP ;
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| Primary / Asst. Examiners: |
Wax, Robert A.; Bugaisky, G. E.
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| INPADOC Legal Status: |
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Family Legal Status Report
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| Parent Case: |
CROSS REFERENCE TO RELATED APPLICATION
This application is a continuation-in-part of application Ser. No. 08/137,800, filed Oct. 19, 1993, now U.S. Pat. No. 5,514,774, which in turn is a continuation-in-part of application Ser. No. 08/084,848, filed Jun. 29, 1993, now U.S. Pat. No. 5,432,155 both of which are incorporated herein by reference.
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| Designated Country: |
BE CH FR GB GR IE IT LI LU MC NL SE KR
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| Family: |
Show 51 known family members
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First Claim:
Show all 11 claims |
What is claimed is:
1. A substanially pure .kappa.-conotoxin peptide selected from the group consisting of:
- Gln-Lys-Glu-Leu-Val-Pro-Ser-Val-Ile-Thr-Thr-Cys-Cys-Gly-Tyr-Asp-Pro-Gly-Thr-Met- Cys-Pro-Pro-Cys-Arg-Cys-Thr-Asn-Ser-Cys-Pro-Thr-Lys-Pro-Lys-Lys-Pro-Xaa1 (SEQ ID NO:25), wherein Xaa1 is des-Xaa1 or Gly-Arg-Arg-Asn-Asp (SEQ ID NO:26);
- Ala-Pro-Xaa1 -Leu-Val-Val-Thr-Ala-Thr-Thr-Asn-Cys-Cys-Gly-Tyr-Asn-Pro-Met-Thr-Ile- Cys-Pro-Pro-Cys-Met-Cys-Thr-Tyr-Ser-Cys-Pro-Pro-Lys-Arg-Lys-Pro-Xaa2 (SEQ ID NO:27), wherein Xaa1 is Glu or γ-carboxyglutamate and Xaa2 is des-Xaa1 or Gly-Arg-Arg-Asn-Asp (SEQ ID NO:26);
- Glx-Thr-Trp-Leu-Val-Pro-Ser-Thr-Ile-Thr-Thr-Cys-Cys-Gly-Tyr-Asp-Pro-Gly-Thr-Met- Cys-Pro-Thr-Cys-Met-Cys-Asp-Asn-Thr-Cys-Lys-Pro-Lys-Pro-Lys-Lys-Ser-Xaa1 (SEQ ID NO:28), wherein Xaa1 is des-Xaa1 or Gly-Arg-Arg-Asn-Asp (SEQ ID NO:26);
- Ala-Pro-Trp-Leu-Val-Pro-Ser-Thr-Ile-Thr-Thr-Cys-Cys-Gly-Tyr-Asp-Pro-Gly-Ser-Met- Cys-Pro-Pro-Cys-Met-Cys-Asn-Asn-Thr-Cys-Lys-Pro-Lys-Pro-Lys-Lys-Ser-Xaa1 (SEQ ID NO:29), wherein Xaa1 is des-Xaa1 or Gly-Arg-Arg-Asn-His (SEQ ID NO:30); and,
- Gly-Cys-Cys-Gly-Pro-Tyr-Xaa1 -Asn-Ala-Ala-Cys-His-Xaa2 -Cys-Gly-Cys-Lys-Val-Gly- Arg-Xaa3 -Xaa4 -Tyr-Cys-Asp-Arg-Xaa5 -Ser-Gly-Gly (SEQ ID NO:33), wherein Xaa1, Xaa2, Xaa3, Xaa4 and Xaa5 are independently Pro or hydroxy-Pro.
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| Background / Summary: |
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| Drawing Descriptions: |
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| Description: |
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| Forward References: |
Show 7 U.S. patent(s) that reference this one
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| Foreign References: |
None
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| Other Abstract Info: |
CHEMABS 123(05)050449G
DERABS C1997-309336
CHEMABS 124(05)048165P
CHEMABS 125(03)028184M
CHEMABS 126(12)152786U
CHEMABS 126(14)182612B
DERABS C1995-061000
DERABS C1995-170189
DERABS C1997-076840
DERABS C1997-309336
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| Other References: |
Cattaneo, M.G. et al. (1993). "Nicotine Stimulates a Serotonergic Autocrine Loop in Human Small-Cell Lung Carcinoma," Cancer Res. 53:5566-5568.
(3 pages)
Cited by 2 patents
[ISI abstract]
Chini, B. et al. (1992). "Neuronal-type α-bungarotoxin receptors and the α5 -nicotinic receptor subunit gene are expressed in neuronal and nonneuronal human cell lines," Proc. Natl. Acad. Sci. USA 89:1572-1576.
(5 pages)
Cited by 13 patents
[ISI abstract]
Codignola, A. et al. (1994). "Serotonin release and cell proliferation are under the control of α-bungarotoxin-sensitive nicotinic receptors in small-cell lung carcinoma cell lines," FEBS Lett. 342:286-290.
(5 pages)
Cited by 2 patents
[ISI abstract]
Fambrough, D.M. et al. (1973). "Neuromuscular Junction in Myasthenia Gravis: Decreased Acetylcholine Receptors," Science 182:293-295.
(3 pages)
Cited by 7 patents
Maneckjee, R. and Minna, J.D. (1990). "Opioid and nicotine receptors affect growth regulation of human lung cancer cell lines," Proc. Natl. Acad. Sci. USA 87:3294-3298 (1990).
(5 pages)
Cited by 5 patents
Olivera, B.M. et al. (1984). "Purification and Sequence of a Presynaptic Peptide Toxin from Conus geographus Venom," Biochemistry 23:5087-5090.
(4 pages)
Cited by 13 patents
Sch uller, H.M. et al. (1990). "Nicotine, Acetylcholine and Bombesin are trophic Growth Factors in Neuroendocrine Cell Lines Derived from Experimental Hamster Lung Tumors," Life Sciences 47:571-578.
Tarroni, P. et al. (1992). "Neuronal-type nicotinic receptors in human neuroblastoma and small-cell lung carcinoma cell lines," FEBS Lett. 312:66-70.
(5 pages)
Cited by 11 patents
[ISI abstract]
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