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Title: US5648532: Compositions for boron neutron capture therapy and methods thereof
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Country: US United States of America

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26 pages

 
Inventor: Hawthorne, M. Frederick; Encino, CA
Feakes, Debra Arliene; Los Angeles, CA
Shelly, Kenneth John; Los Angeles, CA

Assignee: The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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Published / Filed: 1997-07-15 / 1993-06-03

Application Number: US1993000071702

IPC Code: Advanced: A61K 9/127; A61K 33/22; A61K 41/00; A61K 51/00; A61P 35/00; C07F 5/02;
Core: C07F 5/00; more...
IPC-7: C04F 5/02;

ECLA Code: A61K9/127; A61K41/00Z4; C07F5/02D;

U.S. Class: Current: 564/008; 568/004; 568/005;
Original: 564/008; 568/004; 568/005;

Field of Search: 564/008 568/4;5 424/1.61

Priority Number:
1993-06-03  US1993000071702

Abstract: Boron neutron capture therapy can utilize Xy B20 H17 L where X is an alkali metal, y is 1 to 4, and L is a two electron donor such as NH3, and Na2 B10 H9 NCO, among others. These borane salts may be used free or encapsulated in liposomes. Liposomes may have embedded within their bilayers carboranes to increase the amount of delivered 10 B and/or to increase the tumor specificity of the liposome.

Attorney, Agent or Firm: Loeb & Loeb LLP ;

Primary / Asst. Examiners: Kight, John; Kelley, Lara Chapman

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Designated Country: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL  BB BG BR BY CZ FI GE HU KG KP KR KZ LK LV MD MG MN MW NO NZ 

Family: Show 13 known family members

First Claim:
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What is claimed:     1. The compound Nay B20 H17 NH3, where y is 1 or 3.

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Forward References: Show 6 U.S. patent(s) that reference this one

       
U.S. References: Go to Result Set: All U.S. references   |  Forward references (6)   |   Backward references (3)   |   Citation Link

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Patent  Pub.Date  Inventor Assignee   Title
Buy PDF- 4pp US3166378  1965-01 Knoth   Boron hydride carbonyl compounds and processes for making them
Buy PDF- 36pp US3390966  1968-07 Knoth   CHEMICAL PRODUCTS AND THEIR PREPARATION
  US3551120  1970-12 Miller et al.   SUBSTITUTED DODECABORATES
       
Foreign References:
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Publication Date IPC Code Assignee   Title
Get PDF - 37pp EP0179444A2 1986-04  A61K 9/127 CITY OF HOPE NATIONAL MEDICAL CENTER Micellular particle compositions encapsulating imaging and chemotherapeutic agents to tumors and the use thereof 
  GB0956394 1964-04       
Buy PDF- 20pp WO8904176 1989-05  A61K 43/00 VESTAR, INC. COMPOSITION AND METHOD OF USE FOR LIPOSOME ENCAPSULATED COMPOUNDS FOR NEUTRON CAPTURE TUMOR THERAPY 
Buy PDF- 44pp WO9209610 1992-06  A61K 31/69 THE REGENTS OF THE UNIVERSITY OF CALIFORNIA DRUG DELIVERY PORPHYRIN COMPOSITIONS AND METHODS 


Other Abstract Info: CHEMABS 123(07)078659Z DERABS C95-036070

Other References:
  • Solomons, Organic Chemistry, 4th Edition, 1988, pp. 195-197.
  • Li, Ji; Logan, C.F.; and Jones, M. Jr.; "Simple Syntheses and Alkylation Reactions of 3-Iodo-O-Carborane and 9,12-Diiodo-O-Carborane"; Inorg. Chem., vol. 30, No. 25, pp. 4866-4868, 1991. (3 pages) Cited by 3 patents [ISI abstract]
  • Hawthorne, M. Frederick; Pilling, Richard L.; and Garrett, Philip M.; "A Study of the Reaction of Hydroxide Ion with B20 H18 -2 "; Journal of the American Chemical Society, 87:21, pp. 4740-4746, Nov. 5, 1965.
  • Hertler, Walter R.; Knoth, Walter H.; and Muetterties, Earl L.; "Chemistry of Boranes. XXIV. Carbonylation of Derivatives of B10 H102- and B12 H122- with Oxalyl Chloride"; Inorganic Chemistry, vol. 4, No. 3, pp. 288-293, Mar. 1965.
  • Gruner, Sol M.; Ostro Marc J., Editor; "Materials Properties of Liposomal Bilayers"; Princeton University, Princeton, New Jersey, 1990.
  • Shelly, Kenneth; Feakes, D.A.; Hawthorne, M. Frederick; Schmidt, Paul G.; Krisch, Teresa A.; and Bauer, William F.; "Model Studies Directed Toward the Boron Neutron-Capture Therapy of Cancer: Boron Delivery to Murine Tumors with Lipsomes"; Proc. Natl. Acad. Sci. USA, vol. 89, 1992, Medical Sciences.
  • Shelley, Kenneth; Knobler, Carolyn B.; and Hawthorne, M. Frederick; "Synthesis of Monosubstituted Derivatives of closo-Decahydrodecaborate(2-). X-Ray Crystal Structures of [closo-2-B10 H9 CO]- and [closo-2-B10 H9N CO]2- "; Inorganic Chemistry, vol. 31, No. 13, 1992, pp. 2889-2892. (4 pages) Cited by 2 patents [ISI abstract]
  • Presant, C.A.; Blayney, D.; Proffitt, R.T.; Turner, A.F.; Williams, L.E.; Nadel, H.I.; Kennedy, P.; Wiseman, C.; Gala, K.; Crossley, R.J.; Preiss, S.J.; Ksionski, G.E.; and Presant, S.L.; "Preliminary Report: Imaging of Kaposi Sarcoma and Lymphoma in AIDS with Indium-111-Labelled Lipsomes"; The Lancet, vol. 335, pp. 1307-1309, Jun. 2, 1990. (3 pages) Cited by 2 patents
  • Presant, C.A., MD; Proffitt, R.T., Ph.D.; Turner, A.F., MD; Williams, L.E., PhD.; Winsor, D., MD; Werner, J.L., MD; Kennedy, P., MD; Wiseman, C., MD; Gala, K., MD; McKenna, R.J., MD; Smith, J.D., MD; Bouzaglou, S.A., MD; Callahan, R.A., PhD.; Baldeschwieler, J., PhD.; Crossley, R.J., MD; "Successful Imaging of Human Cancer with Indium-111-Labeled Phospholiid Vesicles"; Cancer 62: pp. 906-1011, Sep. 1, 1988.
  • Sullivan, S.M.; "Lipid Particles for Cytoplasmic Delivery of Active Agent--Esp. Oligo-Nucleotide, are Liposome(s) Having Succinimidyl Gps. Extending from Surface"; Abstract (Basic): WO 9205773 A. Apr. 16, 1994.
  • Szoka, F.C.; Chu, C.J.; "Lipsome Compsn.-Congt. Encapsulated Antiviral CPD., e.g. Phosphono-Acetate or Phosphono-Formate, Used to Treat HV and Herpes Simplex Virus-2 Infections"; Abstract (Basic): WO 8905152. Jun. 15, 1989.
  • Presant, C.A; Proffitt, R.T.; Teplitz, R.L.; Williams L.E.; and Tin, G.W.; "Lipsomes(s) for Delivering Imaging Agent or Drug to Tumour Comprising Small Liposome(s) Prepd. from Pure Phospholipid"; Abstract (Basic): EP 179444. Jun. 12, 1991.
  • Hatanaka, H., M.D., D.Sc.; "Boron-Neutron Capture Therapy for Tumors"; 1986.
  • Hawthorne, M.F.; Pilling, R.L.; "The Preparation of B10 H102- Ion", vol. IX, Inorganic Syntheses, Edited by S. Young Tyree, Jr., McGraw-Hill Publishing Co., Inc., NY, NY (1967).
  • Shelly, K. et al., "Model Studies Directed Toward the Boron Neutron-capture Therapy of Cancer: Boron Delivery to Murine Tumors with Liposomes," Proc. Natl. Acad. Sci. USA, vol. 89, No. 19, Oct. 1992, pp. 9039-9043. (5 pages) Cited by 8 patents [ISI abstract]
  • John, K. C. et al., "The Alkylation and Acylation of B10 H9 NH3-," J. Med. Chem., vol. 12, Jan. 1969, pp. 54-57.
  • International Search Report, PCT Application No. PCT/US94/06011 (Oct. 10, 1994).


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