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Title: US5650487: Serum immunoregulatory polypeptides and uses therefor
[ Derwent Title ]

Country: US United States of America

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15 pages

 
Inventor: Chang, Yi-Han; Los Angeles, CA
Abraham, Edward; Denver, CO

Assignee: The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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Published / Filed: 1997-07-22 / 1995-05-31

Application Number: US1995000455645
IPC Code: Advanced: C07K 14/47; A61K 38/00;
Core: C07K 14/435; more...
IPC-7: C07K 7/00; C07K 14/745;

ECLA Code: C07K14/47A1;

U.S. Class: Current: 530/324; 424/185.1; 530/300; 530/327; 530/350;
Original: 530/324; 530/300; 530/327; 530/350; 424/185.1;

Field of Search: 530/350,380,395,300,324-330 424/185.1

Priority Number:
1995-05-31  US1995000455645

Abstract: Previously unisolated serum immunoregulatory polypeptides (SIPs) having a molecular weight of approximately 14,000 to 31,000 are provided. The SIPs may be obtained from hemorrhagic serum of mammals and have been shown to activate suppressor T-cells and suppress lymphocyte proliferation and interleukin production. There is a significant homology between SIPs of different mammalian species. The amino acid sequence of an SIP having a molecular weight of about 16,000 is provided. In addition, immunosuppressive polypeptides are identified which have the formula:
    X-Met-Asp-Ala-His-Pro-Pro-Arg-Leu-Phe-Ala-Cys-Ser-Y
wherein X is an amino acid sequence having from 0 to 10 amino acids and Y is an amino acid sequence having from 0 to 110 amino acids.

Attorney, Agent or Firm: Oppenheimer Poms Smith ;

Primary / Asst. Examiners: Cunningham, Thomas M.;

Maintenance Status: E3 Expired  Check current status
CC Certificate of Correction issued

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Related Applications: Go to Result Set: 1 patent(s) that list this one as related
Application Number Filed Patent Pub. Date  Title
US1994000204486 1994-03-02       
US1991000700110 1991-05-08       
US1988000242739 1988-09-09       


       
Parent Case:     This is a continuation-in-part of application Ser. No. 08/204,486 filed Mar. 2, 1994; which is a continuation-in-part of Ser. No. 07/700,110 filed May 8, 1991, now abandoned; which is a file wrapper continuation of Ser. No. 07/242/739 filed Sep. 9, 1988, now abandoned.

Designated Country: BE CH DK ES FI FR GB GR IE IT LI LU MC NL PT SE  RU 

Family: Show 21 known family members
First Claim:
Show all 21 claims		 What is claimed is:     1. A polypeptide having the formula:
    X-Met-Asp-Ala-His-Pro-Pro-Arg-Leu-Phe-Ala-Cys-Ser-Y
wherein X is an amino acid sequence having from 0 to 5 amino acids and Y is an amino acid sequence having from 0 to 10 amino acids and wherein said polypeptide exhibits suppressive effects on lymphocyte proliferation in vitro.

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Forward References: Show 1 U.S. patent(s) that reference this one

       
U.S. References: Go to Result Set: All U.S. references   |  Forward references (1)   |   Backward references (0)   |   Citation Link

       
Foreign References: None

Other Abstract Info: CHEMABS 113(11)096038U CHEMABS 127(11)145183N CHEMABS 126(08)099311G CHEMABS 127(11)145183N CHEMABS 131(24)321549E DERABS C1990-115957 DERABS C1997-034096

Other References:
  • Kwiatkowski, D. J. et al., Nature 323:455-58, "Plasma and cytoplasmic gelsolins are encoded by a single gene and contain a duplicated actin-binding domain". Oct. 02, 1986. (4 pages) Cited by 7 patents
  • Abraham et al., "Cellular and humoral bases of hemorrhage-induced depression of lymphocyte function," Critical Care Medicine, vol. 14, No. 2, pp. 81-86, 1986. (6 pages) Cited by 2 patents
  • McLoughlin et al., "Correlation between anergy and a circulating immunosuppressive factor following major surgical trauma," Ann. Surg., vol. 190, No. 3, pp. 297-304, 1979. (8 pages) Cited by 3 patents
  • Kohler et al., "Continuous cultures of fused cells secreting antibody of predefined specificity," Nature, vol. 256, pp. 495-497, 1975. (3 pages) Cited by 999 patents
  • Abraham et al., "Effects of hemorrhagic serum on interleukin-2 generation and utilization, " Critical Care Medicine, vol. 16, No. 4, pp. 307-311, 1988. (5 pages) Cited by 2 patents
  • Abraham et al., "The role of interleukin 2 in hemorrhage-induced abnormalities of lymphocyte proliferation," Circulatory Shock, 18-205-213 (1986). (9 pages) Cited by 2 patents
  • Abraham et al., "Generation of functionally active suppressor cells by hemorrhage and haemorrhagic serum," Clin. exp. Immunol. (1988) 72, 238-242.


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